A5089590915- Advanced Neuroimaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Neonatal and fetal brain pathology
- Bone and Joint Diseases
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Anesthesia and Neurotoxicity Research
- COVID-19 and healthcare impacts
- Healthcare cost, quality, practices
- Prenatal Screening and Diagnostics
- Cardiovascular Function and Risk Factors
- Multiple Sclerosis Research Studies
- Cardiac Imaging and Diagnostics
- Healthcare Policy and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Renal cell carcinoma treatment
- Gene expression and cancer classification
- Vascular Malformations Diagnosis and Treatment
- Vestibular and auditory disorders
- Health, Environment, Cognitive Aging
- Immunodeficiency and Autoimmune Disorders
- Spinal Dysraphism and Malformations
- Congenital Diaphragmatic Hernia Studies
- Anesthesia and Sedative Agents
- Tuberous Sclerosis Complex Research
Harvard University
2020-2025
Massachusetts General Hospital
2020-2025
Harvard University Press
2024
Boston Children's Hospital
2020-2023
Cincinnati Children's Hospital Medical Center
2023
Boston University
2021
Abstract The third trimester of pregnancy is a period rapid development fiber bundles in the fetal white matter. Using recently developed motion‐tracked slice‐to‐volume registration (MT‐SVR) method, we aimed to quantify tract‐specific developmental changes apparent diffusion coefficient (ADC), fractional anisotropy (FA), and volume healthy fetuses. To this end, reconstructed tensor images from motion corrected magnetic resonance imaging data. With an approved protocol, MRI exams were...
Success of Nonsedated Neuroradiologic MRI in Children 1–7 Years OldCamilo Jaimes, MD1,2,3, Caroline D. Robson, MBChB1,3, Fedel Machado-Rivas, MD3,4, Edward Yang, MD, PhD1,3, Kellyn Mahan, BA1, Sarah Bixby, MD1,3 and Richard L. Robertson, MD1,3Audio Available | Share
Background Tools in image reconstruction, motion correction, and segmentation have enabled the accurate volumetric characterization of fetal brain growth at MRI. Purpose To evaluate intracranial structures healthy fetuses, accounting for gestational age (GA), sex, laterality with use a spatiotemporal MRI atlas development. Materials Methods T2-weighted 3.0-T half-Fourier acquired single-shot turbo spin-echo sequence was performed fetuses from prospectively recruited pregnant volunteers March...
Fetal MRI has emerged as a cornerstone of prenatal imaging, helping to establish the correct diagnosis in pregnancies affected by congenital anomalies. In past decade, 3 T imaging was introduced an alternative increase signal-to-noise ratio (SNR) pulse sequences and improve anatomic detail. However, at higher field strength is not without challenges. Many artifacts that are barely appreciable 1.5 amplified T. A systematic approach incorporates appropriate patient positioning, thoughtful...
Diffusion-weighted magnetic resonance imaging (DW-MRI) of fetal brain is challenged by frequent motion and signal to noise ratio that much lower than non-fetal imaging. As a result, accurate robust parameter estimation in DW-MRI remains an open problem. Recently, deep learning techniques have been successfully used for subjects. However, none those prior works has addressed the because obtaining reliable training data challenging. To address this problem, work we propose novel methodology...
Population averaged diffusion atlases can be utilized to characterize complex microstructural changes with less bias than data from individual subjects. In this study, a fetal tensor imaging (DTI) atlas was used investigate tract-based in anisotropy and diffusivity vivo 23 38 weeks of gestational age (GA). Healthy pregnant volunteers typically developing fetuses were imaged at 3 T. Acquisition included structural images processed super-resolution algorithm DTI motion-tracked slice-to-volume...
Abstract This work presents detailed anatomic labels for a spatiotemporal atlas of fetal brain Diffusion Tensor Imaging (DTI) between 23 and 30 weeks post‐conceptional age. Additionally, we examined developmental trajectories in fractional anisotropy (FA) mean diffusivity (MD) across gestational ages (GA). We performed manual segmentations on DTI atlas. labeled 14 regions interest (ROIs): cortical plate (CP), subplate (SP), Intermediate zone‐subventricular zone‐ventricular zone (IZ/SVZ/VZ),...
Abstract Background and Purpose To perform a volumetric evaluation of the brain in fetuses with right or left congenital diaphragmatic hernia (CDH), to compare growth trajectories normal fetuses. Methods We identified fetal MRIs performed between 2015 2020 diagnosis CDH. Gestational age (GA) range was 19‐40 weeks. Control subjects consisted normally developing 19 40 weeks recruited for separate prospective study. All images were acquired at 3 Tesla processed retrospective motion correction...
Abstract We utilized motion-corrected diffusion tensor imaging (DTI) to evaluate microstructural changes in healthy fetal brains during the late second and third trimesters. Data were derived from magnetic resonance scans conducted as part of a prospective study spanning 2013 March 2019 May. The included 44 fetuses between gestational ages (GAs) 23 36 weeks. reconstructed brain DTI using motion-tracked slice-to-volume registration framework. Images segmented into 14 regions interest (ROIs)...
Brain injury in fetuses with vein of Galen malformations and nongalenic AVFs is a rare complication whose appearance, course, prognosis are poorly studied. We sought to characterize the MR imaging features examine associations postnatal outcome.This was retrospective analysis fetal MRIs subjects malformation arteriovenous fistulas. Two pediatric neuroradiologists independently reviewed examinations determine presence abnormalities on structural (T1 volumetric interpolated breath-hold...
BACKGROUND. Anesthetic exposure in children may impact long-term neurocognitive outcomes. Therefore, minimizing pediatric MRI scan time under anesthesia and the associated anesthetic is necessary. OBJECTIVE. The purpose of this study was to evaluate as a predictor total propofol dose, considering imaging clinical characteristics covariates. METHODS. Electronic health records were retrospectively searched identify examinations performed from 2016 2019 patients 0-18 years old who received...
Background A lack of in utero imaging data hampers our understanding the connections human fetal brain. Generalizing observations from postmortem subjects and premature newborns is inaccurate due to technical biological differences. Purpose To evaluate changes brain structural connectivity between 23 35 weeks postconceptional age using a spatiotemporal atlas diffusion tensor (DTI). Study Type Retrospective. Population Publicly available atlases, based on 60 healthy women (age 18–45 years)...
Little is known about microstructural development of cerebellar white matter in vivo. This study aimed to investigate developmental changes the peduncles second- and third-trimester healthy fetuses using motion-corrected DTI tractography.
<title>Abstract</title> Background Research on healthcare disparities in pediatric radiology is limited, leading to the persistence of missed care opportunities (MCO). Objective Evaluate social determinants health and sociodemographic factors related MCO before, during, after COVID-19 pandemic. Materials Methods The study examined all outpatient exams at a medical center its affiliate centers from 03/08/19 06/07/21, identify opportunities. Logistic regression with LASSO Classification...