A5088109925- Plant-Microbe Interactions and Immunity
- Plant Molecular Biology Research
- Plant Stress Responses and Tolerance
- Legume Nitrogen Fixing Symbiosis
- Plant Gene Expression Analysis
- Plant tissue culture and regeneration
- Photosynthetic Processes and Mechanisms
- Plant Pathogenic Bacteria Studies
- Plant Reproductive Biology
- Fungal and yeast genetics research
- Plant Parasitism and Resistance
- Plant nutrient uptake and metabolism
- Genomics and Phylogenetic Studies
- Plant Disease Resistance and Genetics
- Plant Genetic and Mutation Studies
- Plant Virus Research Studies
- Transgenic Plants and Applications
- Advanced Proteomics Techniques and Applications
- Polysaccharides and Plant Cell Walls
- Plant Pathogens and Fungal Diseases
- Fungal Biology and Applications
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Microbial Community Ecology and Physiology
- Nematode management and characterization studies
King Abdullah University of Science and Technology
2016-2025
University of Vienna
2006-2023
Max Perutz Labs
2007-2023
Institut des Sciences des Plantes de Paris Saclay
2016-2022
Université Paris-Sud
2013-2022
Centre National de la Recherche Scientifique
2013-2022
Université Paris-Saclay
2017-2022
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021
Sorbonne Paris Cité
2017-2020
Université Paris Cité
2015-2020
Yeast and animals use mitogen-activated protein (MAP) kinase cascades to mediate stress extracellular signals. We have tested whether MAP kinases are involved in mediating environmental responses plants. Using specific peptide antibodies that were raised against different alfalfa kinases, we found exclusive activation of p44MMK4 drought- cold-treated was transiently activated by these treatments correlated with a shift the electrophoretic mobility protein. Although transcript levels MMK4...
The Cf-9 resistance (R) gene from tomato confers to the fungal pathogen Cladosporium fulvum expressing corresponding, pathogen-derived avirulence product Avr9. To understand how an initial R/Avr recognition event is transmitted and triggers induction of plant defenses, we investigated early Avr9/Cf-9-dependent activation protein kinases in transgenic tobacco gene. We identified two 46 48 kD, using myelin basic as substrate, that became rapidly activated a strictly gene-for-gene manner within...
Abstract Plant resistance to disease is controlled by the combination of defense response pathways that are activated depending on nature pathogen. We identified Arabidopsis thaliana BOTRYTIS-INDUCED KINASE1 (BIK1) gene transcriptionally regulated Botrytis cinerea infection. Inactivation BIK1 causes severe susceptibility necrotrophic fungal pathogens but enhances a virulent strain bacterial pathogen Pseudomonas syringae pv tomato. The an avirulent unchanged, limiting role basal rather than...
Excessive amounts of heavy metals adversely affect plant growth and development. Whereas some regions naturally contain high levels metals, anthropogenic release into the environment continuously increases soil contamination. The presence elevated metal ions triggers a wide range cellular responses including changes in gene expression synthesis metal-detoxifying peptides. To elucidate signal transduction events leading to response stress we analyzed protein phosphorylation induced by copper...
Summary Mitogen‐activated protein kinases (MAPKs) appear to be ubiquitously involved in signal transduction during eukaryotic responses extracellular stimuli. In plants, no heat shock‐activated MAPK has so far been reported. Also, whereas cold activates specific plant MAPKs such as alfalfa SAMK, mechanisms of activation are unknown. Here, we report a (HAMK) immunologically related ERK (Extracellular signal‐Regulated Kinase) superfamily kinases. Molecular heat‐activation HAMK and...
Mitogen-activated protein kinase kinases (MAPKKKs) play key roles in intra- and extracellular signaling eukaryotes. Here we report that the MAPKKK MEKK1 regulates redox homeostasis Arabidopsis. We show MEKK1-deficient plants are misregulated expression of a number genes involved cellular control accumulate reactive oxygen species (ROS). Most strikingly, homozygous mekk1 mutant exhibit lethal phenotype when developing true leaves. activity stability was regulated by H(2)O(2)...
Abstract Wound signaling pathways in plants are mediated by mitogen-activated protein kinases (MAPKs) and stress hormones, such as ethylene jasmonates. In Arabidopsis thaliana, the transmission of wound signals MAPKs has been subject detailed investigations; however, involvement specific phosphatases is not known. Here, we show that AP2C1, an Ser/Thr phosphatase type 2C, a novel signal regulator inactivates stress-responsive MPK4 MPK6. Mutant ap2c1 produce significantly higher amounts...
Alternative splicing generates multiple transcript and protein isoforms from the same gene thus is important in expression regulation. To date, RNA-sequencing (RNA-seq) standard method for quantifying changes alternative on a genome-wide scale. Understanding current limitations of RNA-seq crucial reliable analysis lack high quality, comprehensive transcriptomes most species, including model organisms such as Arabidopsis, major constraint accurate quantification isoforms. address this, we...