Abstract Background Enhanced recovery protocols (ERPs) accelerate patient and shorten hospital stay by optimization of perioperative care. However, experience with ERPs is still limited in liver surgery. Methods The implementation a multimodal ERP was studied patients who underwent open laparoscopic An opioid-sparing pain treatment chosen together early mobilization oral feeding, as well restricted use abdominal drains catheters. Date to discharge, postoperative complications satisfaction...

Background: Indeterminate biliary strictures, that is, a stricture with benign brush cytology but without clear etiology in clinical or radiological assessment, pose challenge for clinicians. This study aimed to assess the incidence and risk factors malignant disease patients indeterminate strictures. Methods: is single-center retrospective of undergoing first endoscopic retrograde cholangiopancreatography (ERCP) brushing between March 2011 2020. The included atypical ERCP samples. Main...

Background. Chronic allograft nephropathy (CAN) is the primary reason for late loss in kidney transplantation, and currently there no treatment available it. Platelet-derived growth factor (PDGF) suggested to be a major mitogen mediating mesenchymal cell proliferation CAN. It has been shown that PDGF already induced at acute renal rejection, indicating link between rejection subsequent development of However, definite effect on pathogenesis CAN still unknown. We investigated role by...

Study Design Ninety disc herniations removed during surgery were studied by immunocytochemistry, using two different endothelial cell markers, to study the prevalence, morphology, and topography of blood vessels in herniations. Objectives To increase specific localization even very small present antibodies cells; comparatively with antibodies, comparing their prevalence; vessel morphology topographic relationships other tissue elements, particularly cells. Summary Background Data In many...

Leflunomide (LFM) inhibits experimentally both acute and chronic allograft rejection. The inhibition of dihydroorotate dehydrogenase (DHODH) in pyrimidine synthesis is suggested to be the major immunosuppressive mechanism. mechanism its vasculoprotective effect not known, although it may linked receptor tyrosine kinases (RTK). Here, we have investigated whether sufficient could obtained upon administration FK778, a LFM analogue with shorter half-life, compared dose response that known...

Chronic allograft injury remains a major problem in clinical kidney transplantation and different growth factors participate its development. Epidermal factor (EGF) affects cell proliferation mitogenesis through tyrosine kinase receptor. Erlotinib is an orally administered inhibitor used oncology to inhibit EGF signaling. We investigated effect on the development of chronic experimental model.Kidney transplantations were performed between Dark Agouti Wistar Furth rats. Recipients...

Background. Chronic allograft nephropathy (CAN), now defined as interstitial fibrosis and tubular atrophy not otherwise specified, is a near universal finding in kidney grafts by the end of first decade posttransplantation. Platelet-derived growth factor (PDGF) major mitogen mediating mesenchymal cell proliferation CAN. Here, we investigated whether early short-term PDGF inhibition with imatinib could prevent Methods. Kidney transplantations were performed from Dark-Agouti (DA) to...

Oral disease is linked with systemic inflammation and various conditions, including chronic liver disease. Liver transplantation (LT) candidates often need dental infection focus eradication, after LT, there high risk of many inflammation-related complications. We studied whether pre-LT status associated the occurrence post-LT This study included 225 adult LT recipients whose teeth were examined treated before 40 who did not have data available. Data on complications collected from national...

In the development of chronic kidney allograft rejection acute (AR) is single most important risk factor. Although Cyclosporin A (CsA) medication has decreased incidence AR, (CR) still major reason for late loss. Platelet-derived growth factor (PDGF) a mitogen mediating mesenchymal cell proliferation in CR. We have investigated impact AR and different doses CsA on expression PDGF ligands receptors CR.Kidney transplantations were performed from DA to WF rats syngenic controls done rats. Two...

Acute rejection is the single most important risk factor for development of subsequent chronic rejection. Platelet-derived growth (PDGF) a major mitogen that mediates mesenchymal cell proliferation in Therefore, we investigated whether PDGF ligands and receptors are induced during acute renal allograft rat.Kidney transplantations were performed from Dark Agouti (DA) to Wistar-Furth (WF) rats, syngenic controls DA rats. Allografts immunosuppressed with cyclosporine (CsA) 1.5 mg/kg/d...

Several perioperative scoring systems have been created to predict outcomes in metastatic colorectal cancer; however, these rarely include histological parameters. We evaluated factors used for patients with liver metastases operated between 2000 and 2019 compared the results Fong score. Many models overall disease‐free survival (DFS) were established using multivariate Cox proportional hazard models. Statistically significant predictors at a 5% level univariate analysis included backward...

Abstract Introduction Enhanced recovery protocols (ERP) accelerate and shorten postoperative hospital stay. This increased knowledge of ERPs has also gradually implemented into liver surgery. However, in laparoscopic surgery (LLS), the experience optimized perioperative care is still limited. Methods We prospectively studied implementation multimodal ERP principles to LLS first 100 consecutive patients. Opioid-sparing pain management was applied together with early mobilization already unit...

Expression of both platelet-derived growth factor (PDGF) and vascular endothelial (VEGF) is increased during the development chronic rejection which remains major reason for late allograft loss in clinical kidney transplantation. Sunitinib a tyrosine kinase inhibitor inhibits VEGF PDGF receptors. Here we investigated its effect on rejection.Rat aortic denudation model was used to define sunitinib dose. In vitro studies were done investigate smooth muscle cell proliferation migration. Kidney...

Acute rejection is the major risk factor for development of subsequent chronic allograft nephropathy (CAN), which primary reason late loss in kidney transplantation. Platelet-derived growth (PDGF) and transforming factor-beta (TGF-beta) are main mitogens mediating mesenchymal cell proliferation. Their early post-transplant induction may start cascades leading to CAN. An immunosuppressive drug, FK778, inhibits de novo pyrimidine biosynthesis several receptor tyrosine kinases (RTKs). Here we...

Objective: The objective of this study was to investigate the short-term and long-term morbidity after liver transplantation (LTx) in patients with primary sclerosing cholangitis (PSC). Background: PSC is a common indication for LTx Scandinavia. Recently, research has focused on survival morbidity. Comprehensive Complication Index (CCI) precisely describes postsurgical complications, by considering both number severity. Patients Methods: Two patient groups were compared: those classical...