- Dialysis and Renal Disease Management
- Mobile Health and mHealth Applications
- Renal Diseases and Glomerulopathies
- Central Venous Catheters and Hemodialysis
- Vasculitis and related conditions
- Telemedicine and Telehealth Implementation
- Medication Adherence and Compliance
- Digital Mental Health Interventions
- Restless Legs Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Effects and Toxicity Studies
- Adolescent and Pediatric Healthcare
- Urticaria and Related Conditions
- Research in Social Sciences
- Renal and Vascular Pathologies
- Sleep and Wakefulness Research
- Heart Failure Treatment and Management
- Nephrotoxicity and Medicinal Plants
- Systemic Lupus Erythematosus Research
- Sepsis Diagnosis and Treatment
- Chronic Disease Management Strategies
- Chronic Kidney Disease and Diabetes
- Celiac Disease Research and Management
- Psychosomatic Disorders and Their Treatments
- Autoimmune Bullous Skin Diseases
Helsinki University Hospital
2015-2025
University of Helsinki
2014-2025
Hospital District of Helsinki and Uusimaa
2023-2024
Background. The purpose of this retrospective study was to analyse patients from four centres in three continents determine if differences long-term outcome IgA nephropathy (IgAN) are explained by clinical and laboratory features at presentation.
Background and Aims: Stenosis due to intimal hyperplasia restenosis after initially successful percutaneous angioplasty are common reasons for failing arteriovenous fistulas. The aim of this study was evaluate the effect drug-coated balloons in treatment fistula stenosis. Design: Single-center, parallel group, randomized controlled trial. Block by sealed envelope 1:1. Materials Methods: A total 39 patients with primary or recurrent stenosis a native fistulas were balloon (n = 19) standard...
Background Chronic kidney disease (CKD) is a common condition worldwide and home dialysis (HD) provides economic, quality of life, clinical advantages compared to other modalities. Human-centered design aims support the development eHealth solutions with high usability user experience. However, research on needs patients using HD scarce. Objective This study aimed for CKD, particularly HD, by developing experience map that illustrates needs, concerns, barriers. The questions were (1) what...
A number of factors are linked to the outcome IgA nephropathy (IgAN). However, it has been difficult compare results studies since patient populations have varied greatly. There were 3 aims in study reported here, namely associated with renal IgAN patients different levels function on diagnosis; determine which independently progression disease initially mild IgAN; and create a model for estimation risk individual normal diagnosis.Two hundred fifty-nine who had followed average 9.1 (SD 4.5)...
Home haemodialysis (HHD) is undergoing a significant revival. There global demographic shift with rising mean age of dialysis patients. We postulated that intensive HHD may also benefit the older population. However, there lack literature on feasibility in patients end-stage renal disease (ESRD). The purpose this study was to ascertain delivering conducted multi-centre multinational retrospective cohort ≥65 years at time initiation; 79 were included. Baseline data included start dialysis,...
Henoch-Schoenlein purpura (HSP) is a small vessel vasculitis that often involves the kidneys. It affects many more children than adults. Few studies on HSP nephritis (HSN) in adult patients have been reported. One aim of study described here was to determine clinical features adults diagnosed at single center as suffering from HSN. Other aims were record outcomes disease and factors associated with its progression.Between 1980 1995, 42 attending our clinic consecutively, by means renal...
Familial clustering and genome-wide linkage scans strongly support a genetic susceptibility to familial IgA nephropathy (IgAN), but factors that predispose sporadic IgAN are unknown. A high-throughput single nucleotide polymorphism (SNP) association study was conducted using customized Illumina BeadChip in 732 white patients with biopsy-proven 503 control subjects from Canada, France, Finland. Approximately 93% of 1536 SNPs on the array were tag Phase I+II HapMap minor allele frequency > or...
Objectives Infections are the most common non-cardiovascular cause of death among dialysis patients. Earlier studies have shown similar or higher risk infectious complications in peritoneal (PD) compared to hemodialysis (HD) patients, but comparisons home HD patients been rare. We investigated severe infections after start continuous ambulatory PD (CAPD) and automated (APD) as HD. Methods All adult (n = 536), who were on at day 90 from starting kidney replacement therapy (KRT) between 2004...
ABSTRACT Background Several studies have shown superior survival of patients on home haemodialysis (HD) compared with peritoneal dialysis (PD), but automated PD (APD) and continuous ambulatory (CAPD) not been considered separately. As APD allows larger fluid volumes may be more efficient than CAPD, we primarily patient between HD. Methods All adult who started kidney replacement therapy (KRT) 2004 2017 in the district Helsinki-Uusimaa Finland were one modalities at 90 days from starting KRT...
eHealth solutions such as digital patient engagement platforms (DPEPs) aim at enhancing communication and collaboration between patients clinicians. From the clinicians’ viewpoint, concerns exist about new information systems (IS) leading to increased workload interoperability problems. This article aims support development implementation of DPEPs from end-users’ perspective. We studied needs for a DPEP developed home dialysis (HD) care. Eight clinicians participated in remote...
Key Points We observed a comparable cumulative incidence of major adverse cardiovascular event (MACE) in in-center hemodialysis (IC-HD) and continuous ambulatory peritoneal dialysis (PD) patients, which was higher than automated PD home patients. After adjustment for confounders, there no difference risk MACE between patients on modalities IC-HD. Compared with IC-HD, associated lower among female male Background Among events are the leading cause death. Little is known about how frequency...
IgA nephropathy (IgAN) and Henoch-Schönlein nephritis (HSN) share many clinical, histological immunological features. It has been postulated that these two conditions have a common pathogenesis HSN might be systemic form of IgAN. Activity interleukin-1beta (IL-1beta) in urine found to higher IgAN patients than healthy controls. Interaction between IL-1beta interleukin-1 receptor antagonist (IL-1ra) plays significant role the regulation inflammatory responses. We studied levels urinary...
Background Chronic kidney disease affects 10% of the population worldwide, and number patients receiving treatment for end-stage is forecasted to increase. Therefore, there a pressing need innovative digital solutions that increase efficiency care improve patients’ quality life. The aim eHealth in Home Dialysis project create novel solution, called eC4Me, facilitate predialysis home dialysis with chronic disease. Objective Our study aimed evaluate usability, user experience (UX), patient...
OBJECTIVE: To investigate efficacy of rotigotine transdermal system in patients with restless legs syndrome (RLS) and end-stage renal disease (ESRD) requiring hemodialysis. BACKGROUND: RLS occurs ~20[percnt] ESRD is linked to increased morbidity mortality. may be particularly bothersome when are immobile during dialysis. Periodic limb movements (PLM) sleep frequently occur RLS. PLM Index (PLMI; PLM/hours bed) an objective severity measure. DESIGN/METHODS: This double-blind polysomnographic...
Uuden kotidialyysihoidon sähköisen palvelun tavoitteena on sujuvoittaa ja tukea potilaiden hoitoa. Palvelun loppukäyttäjien huomioiminen osallistaminen kehittämistyöhön tärkeää, jotta palvelu voidaan ottaa laajasti käyttöön se koetaan hyödylliseksi. Tässä artikkelissa kuvataan tutkimus, jonka oli selvittää kotidialyysipotilaiden heitä hoitavien ammattilaisten tarpeita kokemuksia uudelle kehitettävälle sähköiselle ratkaisulle, joka sisältää sovelluksen erilaisia mittareita. Tutkimus osa...
Abstract Background and Aims Among dialysis patients, cardiovascular events are the leading cause of death. Little is known about difference in frequency between various modalities. Glucose load may contribute to a metabolic burden peritoneal (PD). On other hand, hemodialysis can intradialytic hypotension, cardiac stunning, arrhythmias, which associated with increased risk We compared major patients who started continuous ambulatory PD (CAPD), automated (APD) home HD in-center patients....
<sec> <title>BACKGROUND</title> Chronic kidney disease affects 10% of the population worldwide, and number patients receiving treatment for end-stage is forecasted to increase. Therefore, there a pressing need innovative digital solutions that increase efficiency care improve patients’ quality life. The aim eHealth in Home Dialysis project create novel solution, called eC4Me, facilitate predialysis home dialysis with chronic disease. </sec> <title>OBJECTIVE</title> Our study aimed evaluate...
<sec> <title>BACKGROUND</title> Chronic kidney disease (CKD) is a common condition worldwide and home dialysis (HD) provides economic, quality of life, clinical advantages compared to other modalities. Human-centered design aims support the development eHealth solutions with high usability user experience. However, research on needs patients using HD scarce. </sec> <title>OBJECTIVE</title> This study aimed for CKD, particularly HD, by developing experience map that illustrates needs,...