A5102898170- Viral Infections and Vectors
- Antibiotic Use and Resistance
- Vector-borne infectious diseases
- Long-Term Effects of COVID-19
- Nosocomial Infections in ICU
- Emergency and Acute Care Studies
- Clostridium difficile and Clostridium perfringens research
- Patient Satisfaction in Healthcare
- Healthcare Systems and Technology
- Viral Infections and Outbreaks Research
- Research in Social Sciences
- Antimicrobial Resistance in Staphylococcus
- Fire effects on ecosystems
- Microscopic Colitis
- Bacterial Identification and Susceptibility Testing
- Bacterial biofilms and quorum sensing
- Urinary Tract Infections Management
- Healthcare cost, quality, practices
- Infection Control in Healthcare
- Diet and metabolism studies
- Dermatological diseases and infestations
- COVID-19 and Mental Health
- Primary Care and Health Outcomes
- Viral gastroenteritis research and epidemiology
- Mosquito-borne diseases and control
Helsinki University Hospital
2012-2025
University of Helsinki
1996-2025
Turku University Hospital
2023-2025
University of Turku
2025
Hospital District of Helsinki and Uusimaa
2023
Finnish Institute for Health and Welfare
2009-2015
Kainuun keskussairaala
2012
Finnish Food Authority
2010
Institute for Molecular Medicine Finland
2007-2008
Finnish Red Cross
1996
SUMMARY Puumala virus (PUUV) causes mild haemorrhagic fever with renal syndrome, a rodent-borne zoonosis. To evaluate the disease burden of PUUV infections in Finland, we analysed data reported by laboratories to National Infectious Disease Registry during 1995–2008 and compared these from other national registries (death, 1998–2007; hospital discharge, 1996–2007; occupational diseases, 1995–2006). A total 22 681 cases were (average annual incidence 31/100 000 population); 85% persons aged...
ObjectivesThe aim of this study was to investigate antimicrobial prescribing in nursing homes countries across Europe.
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Background Persistent somatic symptoms unexplained by a defined medical or psychiatric condition often include component of central sensitization. Many treatment options are based on cognitive behavioral therapy. Effective widely available therapies scarce. There self-management programs and e-therapies that aim at overcoming the sensitization modifying interoceptive neural networks in brain. Objectives This study aims to investigate effect mindfulness-based amygdala insula retraining (AIR)...
The diagnosis of Lyme neuroborreliosis (LNB) requires the demonstration intrathecal synthesis Borrelia antibodies in a patient's cerebrospinal fluid (CSF), which involves invasive procedure lumbar puncture. This study serves as feasibility aimed at exploring potential using serum samples, are easily obtainable routine clinical for LNB diagnostics via advanced metabolomics techniques. Serum samples were collected from confirmed patients before and after treatment, with post-treatment serving...
Background The mechanisms underlying persistent symptoms after non-severe COVID-19 remain unclear. This study aimed to investigate transcriptomic changes in peripheral blood cells of patients with post-COVID-19 condition (PCC) and assess if distinct clinical subtypes specific gene signatures could be identified. Methods cohort included 111 PCC from the SARS-CoV-2 Omicron variant era, 57 recovered (Recov) 54 having prolonged indicative PCC. results were compared 63 healthy controls (Ctrl)...
Lyme neuroborreliosis (LNB) is often treated with intravenous ceftriaxone even if doxycycline suggested to be noninferior ceftriaxone. We evaluated the efficacy of oral in comparison treatment LNB.Patients neurological symptoms suggestive LNB without other obvious reasons were recruited. The inclusion criteria (1) production Borrelia burgdorferi-specific antibodies cerebrospinal fluid (CSF) or serum; (2) B. burgdorferi DNA CSF; (3) an erythema migrans during past 3 months. Participants...
Nationwide surveillance identified 10 human isolates of methicillin-resistant Staphylococcus aureus clonal complex (CC) 398. Further typing in comparison with animal 4 clusters: 1 related to a horse epidemic and 3 persons who had no direct contact animals or each other. These findings may indicate unrecognized community transmission.
We aimed to identify clinically relevant clusters among patients with post-Covid-19 condition (PCC) and assess prognosis overall within clusters. Prospective cohort study of PCC attending a rehabilitation clinic. monitored patient reported outcome measures (PROMs): EuroHIS quality life symptoms. Unsupervised hierarchical cluster analyses were performed different quantity symptoms, symptoms presenting together. Preliminary findings on symptom prevalence at 12 months are reported. Among 409...
Puumala orthohantavirus-caused hemorrhagic fever with renal syndrome (PUUV-HFRS) is characterized by strong neutrophil activation. Neutrophils are the most abundant immune cell type in circulation and specially equipped to rapidly respond infections. They more heterogenous than previously appreciated, specific subsets recently implicated inflammation immunosuppression. Furthermore, neutrophils can be divided based on their density either low-density granulocytes (LDGs) or "normal density"...
ABSTRACT A nationwide population-based study on community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Finland during 2004 to 2006 showed that both incidence (1.9/100,000 population) and strain variation increased comparison years 1997 1999. There were 7 epidemic 25 sporadic MRSA types. Half of these had Panton-Valentine leukocidin genes.
Objectives Infections are the most common non-cardiovascular cause of death among dialysis patients. Earlier studies have shown similar or higher risk infectious complications in peritoneal (PD) compared to hemodialysis (HD) patients, but comparisons home HD patients been rare. We investigated severe infections after start continuous ambulatory PD (CAPD) and automated (APD) as HD. Methods All adult (n = 536), who were on at day 90 from starting kidney replacement therapy (KRT) between 2004...
It is difficult to draw conclusions about the prudence of antibiotic use in different hospitals by directly comparing usage figures. We present a patient case-mix adjustment model rank while taking characteristics into account.Data on were collected during national healthcare-associated infection (HAI) prevalence survey 2005 Finland all 5 tertiary care, 15 secondary care and 10 (25% 40) other acute hospitals. The antibiotics was measured using use-days/100 patient-days 7day period patients...
Abstract Background After COVID-19 infection, 10–20% of patients suffer from varying symptoms lasting more than 12 weeks (Long COVID, LC). Exercise intolerance and fatigue are common in LC. The aim was to measure the maximal exercise capacity LC with these analyze whether this related heart rate (HR) responses at rest during recovery, find out possible sympathetic overactivity, dysautonomia or chronotropic incompetence. Methods Cardiopulmonary test conducted on 101 patients, who were...
Knowledge of the burden healthcare-associated infections (HAI) and antibiotic resistance is important for resource allocation in infection control. Although national surveillance networks do not routinely cover all HAIs due to multidrug-resistant bacteria, estimates are nevertheless possible: EU, 25,000 patients die from such annually. We assessed bacteria Finland 2010.By combining data National Infectious Disease Registry on numbers bacteremias caused by Staphylococcus aureus, Enterococcus...
Background: We present here a case of haemorrhagic brain infarction in middle-aged and physically active male, who had never smoked. This report aims to remind the internist neurologist bear mind unusual aetiologies infarcts patients without classical cardiovascular risk factors. Case Description: A 49-year-old male with pulmonary asthma prior history nasal polyps wake-up stroke left-sided symptoms speech disturbance. head MRI MR angiography revealed recent infarct right putamen corona...
Introduction After COVID-19, many continue to experience persistent debilitating symptoms, that is, long COVID. Its most prevalent symptoms are chest pain, difficulties with breathing, painful muscles, ageusia or anosmia, tingling extremities and general tiredness. This paper describes the protocol of Long COVID Cohort Study assess prognosis prognostic determinants patients by implementing patient-reported outcome measures (PROMs), (PREMs) clinical examinations during a 1-year follow-up....