A5037570504- Cytomegalovirus and herpesvirus research
- RNA regulation and disease
- interferon and immune responses
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Cell death mechanisms and regulation
- Phagocytosis and Immune Regulation
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Herpesvirus Infections and Treatments
Finnish Institute for Health and Welfare
2025
European Centre for Disease Prevention and Control
2025
Helmholtz Centre for Infection Research
2020-2021
de Duve Institute
2017
Interferon-stimulated gene products (ISGs) play a crucial role in early infection control. The ISG zinc finger CCCH-type antiviral protein 1 (ZAP/ZC3HAV1) antagonizes several RNA viruses by binding to CG-rich sequences, whereas its effect on DNA is less well understood. Here, we decipher the of ZAP context human cytomegalovirus (HCMV) infection, β-herpesvirus that associated with high morbidity immunosuppressed individuals and newborns. We show expression two major isoforms ZAP, ZAP-S ZAP-L,...
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Cryptosporidium is a significant cause of foodborne outbreaks. The 60 kDa glycoprotein gene (gp60) most often used for subtyping species but not always sufficient defining clusters and infections sources. Multilocus Variable-Number Tandem-Repeat Analysis (MLVA) scheme has been developed to better differentiate between subtypes. A cryptosporidiosis outbreak, with 35 cases, was detected in Finland September 2022. At the same time, Sweden, three outbreaks, 107 were detected, leading...
ATM, primarily activated by DNA double-strand breaks, and ATR, single-stranded DNA, are master regulators of the cellular response to damage. In primary chronic lymphocytic leukemia (CLL) cells, ATR signaling is considered be switched off due downregulation. Here, we hypothesized that though expressed at low protein level, could play a role in resting CLL cells after genotoxic stress. By investigating UV-C irradiation, prototypical activator detect phosphorylation Thr-1989, marker for...
Abstract Interferon-stimulated gene products (ISGs) play a crucial role in early infection control. The ISG zinc finger CCCH-type antiviral protein 1 (ZAP/ZC3HAV1) antagonises several RNA viruses by binding to CG-rich sequences, whereas its effect on DNA is largely unknown. Here, we decipher the of ZAP context human cytomegalovirus (HCMV) infection, β-herpesvirus that associated with high morbidity immunosuppressed individuals and newborns. We show expression two major isoforms ZAP, long...