A5011945679- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Neuroblastoma Research and Treatments
- Liver Disease and Transplantation
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Esophageal and GI Pathology
- Cancer, Hypoxia, and Metabolism
- Gastrointestinal Tumor Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- MRI in cancer diagnosis
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Organ Transplantation Techniques and Outcomes
- Cancer Research and Treatments
- Cancer Cells and Metastasis
Tokyo Medical and Dental University
2013-2025
Institute of Science Tokyo
2025
Tokyo National Hospital
2021-2024
National Cancer Center Hospital East
2022-2024
Kunming Children's Hospital
2023
National Cancer Center
2008-2022
Tokyo Medical and Dental University Hospital
2016
Northwestern University
2015
National Cancer Research Institute
2010
Abstract Early on, laparoscopic liver resection ( LLR ) was limited to partial resection, but major is no longer rare. A difficulty scoring system required guide surgeons in advancing from simple highly technical resections. Subjects were 90 patients who had undergone pure at three medical institutions (30 patients/institution) J anuary 2011 pril 2014. Surgical assessed by the operator using an index of 1–10 with following divisions: 1–3 low difficulty, 4–6 intermediate and 7–10 high...
BackgroundHepatocellular carcinoma (HCC) is a heterogeneous disease with various etiological factors, and ranks as the second leading cause of cancer-related mortality worldwide due to multi-focal recurrence. We herein identified three major subtypes HCC by performing integrative analysis two omics data sets, clarified that this classification was closely correlated clinicopathological immune profiles recurrence patterns.MethodsIn test study, 183 tumor specimens surgically resected from...
The Brisbane 2000 Terminology for Liver Anatomy and Resections, based on Couinaud's segments, did not address how to identify segmental borders anatomic territories of less than one segment. Smaller resections including segmentectomies subsegmentectomies, have been well defined. advent minimally invasive liver resection has enhanced the possibilities more precise due a magnified view reduced bleeding, (MIALR) is becoming popular gradually. Therefore, there need updating system, segmentectomy...
Laparoscopic pancreaticoduodenectomy (LPD) requires sufficient laparoscopic training for optimal outcomes. Our aim is to determine the learning curve and investigate factors influencing surgical outcomes during curve.We analyzed results of 150 consecutive cases LPD performed by three hepatopancreatobiliary surgeons their 50 first cases. Learning curves were constructed cumulative sum (CUSUM) analysis. Preoperative resection time blood loss investigated in introductory stable periods. RESULTS...
The concept of minimally invasive anatomic liver resection (MIALR) is gaining popularity. However, specific technical skills need to be acquired safely perform MIALR. "Expert Consensus Meeting: Precision Anatomy for Minimally Invasive HBP Surgery (PAM-HBP Consensus)" was developed as a special program during the 32nd meeting Japanese Society Hepato-Biliary-Pancreatic (JSHBPS).Thirty-four international experts gathered online consensus. A Research Committee performed comprehensive literature...
To investigate whether tangential versus segmental portomesenteric venous resection (PVR) impacts surgical and oncological outcome in patients undergoing pancreatoduodenectomy for pancreatic cancer with vein (PMV) involvement. Current comparative studies on PVR as part of include all degrees PMV involvement, including cases where may not be a feasible approach, limiting the clinical applicability. International retrospective study 10 centers from 5 countries, consecutive after ≤180°...
Patients with pancreatic cancer typically develop tumor invasion and metastasis in the early stage. These malignant behaviors might be originated from stem cells (CSCs), but responsible target is less known about invisible CSCs especially for metastasis. We previously examined proteasome activity of constructed a real-time visualization system human CSCs. In present study, we found that were highly metastatic dominantly localized at invading margins liver model. Microarray siRNA screening...
Abstract Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies because recurrence and/or metastasis even after curative resection. Emerging evidence suggests that tumor and might be driven by a small subpopulation stemness cells, so-called cancer stem cells (CSCs). Previous investigations have revealed glioma breast CSCs exhibit intrinsically low proteasome activity also reportedly contain lower reactive oxygen species (ROS) level than corresponding nontumorigenic cells....
Although genomic analysis have recently discovered the malignant subtype of human pancreatic ductal adenocarcinoma (PDAC) characterized by frequent mutations histone demethylase KDM6A, biological and molecular roles still remain obscure. We herein elucidated clinical impacts KDM6A deficiency on PDAC identified therapeutic potential pathological evaluation. Immunohistochemical suggested that loss in cancerous tissues was an independent prognostic factor for both recurrence‐free overall...
Abstract Background Several factors affect the level of difficulty laparoscopic distal pancreatectomy ( LDP ). The purpose this study was to develop a scoring DS ) system quantify degree in . Methods We collected clinical data for 80 patients who underwent LDP. A 10‐level index developed and subcategorized into three‐level index; 1–3 as low, 4–6 intermediate, 7–10 high index. automatic linear modeling (LINEAR) statistical tool used identify that significantly increase Results operator's...
To investigate the frequency of laparoscopic liver resection (LLR) nationwide in Japan.LLR was initially limited to basic resection, but is becoming more common advanced resection.Retrospective observational study 148,507 patients registered National Clinical Database 2011-2017. Excluded: with biliary and vascular reconstruction.LLR or open (OLR) performed 1848 (9.9%) 16,888 (90.1%) patients, respectively, 2011, whereas 2017, LLR had increased 24.8% OLR decreased 75.2% resections (5648...
Antiangiogenic therapy is initially effective for several solid tumors including hepatocellular carcinoma; however, they finally relapse and progress, resulting in poor prognosis. We here established vivo drug-tolerant subclones of human carcinoma cells by long-term treatment with VEGF receptor (VEGFR) inhibitor serial transplantation immunocompromised mice (total 12 months), then compared them the parental molecular biological features. Gene expression profiles elucidated a G-actin monomer...
Abstract The activity of histone acetyltransferases (HATs) plays a central role in an epigenetic modification cooperation with HDACs (histone deacetyl transferases). It is likely that malfunction this enzymatic machinery controlling relevant to carcinogenesis and tumor progression. However, pancreatic cancer, the clinical relevance HAT acetylation has remained unclear. We identified H3 was expressed all cancer patients, indicating may be essential cells. also found inhibitor C646 augmented...