A5048937962- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Pancreatic and Hepatic Oncology Research
- Cytomegalovirus and herpesvirus research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Microgrid Control and Optimization
- Phagocytosis and Immune Regulation
Institute of Medical Microbiology and Hygiene
2020-2022
Technical University of Munich
2020-2022
Abstract While antigen-primed T cells proliferate at speeds close to the physiologic maximum of mammalian cells, cell memory is maintained in absence antigen by rare divisions. The transition between these distinct proliferative programs has been difficult resolve via population-based analyses. Here, we computationally reconstruct history single CD8 + upon vaccination and measure division speed emerging subsets vivo. We find that slower cycling central precursors, characterized an elongated...
Evolutionary processes govern the selection of T cell clonotypes that are optimally suited to mediate efficient antigen-specific immune responses against pathogens and tumors. While theoretical diversity receptor (TCR) sequences is vast, TCR repertoire restricted by its peptide epitope presenting major histocompatibility complex (pMHC). It remains unclear how many recruited into an response, both within across different organisms, which factors shape these distributions. Infection mice with...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a complex disease displaying genetic heterogeneity along with tumor microenvironment (TME) unique in its composition. Whereas the PDAC TME known to be highly immunosuppressive, it remains elusive how distinct alterations affect cell type recruitment and this, turn, influences progression treatment outcome. Therefore, we systematically investigated composition tumor-immune crosstalk molecular subtypes. We delineated landscape of...