A5033679569- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Surgical Simulation and Training
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Peptidase Inhibition and Analysis
- Genetic factors in colorectal cancer
- Simulation-Based Education in Healthcare
- Nutrition and Health in Aging
- Chronic Lymphocytic Leukemia Research
- Amoebic Infections and Treatments
- Clinical practice guidelines implementation
- Cardiac Structural Anomalies and Repair
- AI in cancer detection
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal Cancer Research and Treatment
Seoul National University
2022-2025
Seoul National University Hospital
2021-2024
Seoul Metropolitan Government
2024
Boramae Medical Center
2024
Abstract Background Benefits of neoadjuvant treatment for pancreatic cancer with major vessel invasion has been demonstrated through randomized controlled trials; however, the optimal strategy remains controversial, especially radiotherapy. Therefore, we aimed to evaluate efficacy and safety radiotherapy followed by chemotherapy time interval undergo surgery after in (borderline) resectable cancer. Methods Between 2013 2022, patients contact who received 5-fluorouracil leucovorin,...
Importance Despite the increasing prevalence of intraductal papillary mucinous neoplasm (IPMN), data on growth and malignant conversion rates based long-term surveillance cohorts are limited. Many international guidelines recommend for benign lesions, but optimal interval duration unclear. Objective To determine protocol IPMN propose which patients may be exempted from surveillance. Design, Setting, Participants This large-scale, cohort study examined 3825 with treated at 5 tertiary...
Abstract Background This study aimed to investigate the oncologic long-term safety of proximal gastrectomy for upper-third advanced gastric cancer (AGC) and Siewert type II esophagogastric junction (EGJ) cancer. Methods The enrolled patients who underwent (PG) or total (TG) with standard lymph node (LN) dissection pathologically proven AGC EGJ cancers between January 2007 December 2018. Propensity score-matching a 1:1 ratio was performed reduce influence confounding variables such as age,...
After the World Health Organization established a precise definition of mucinous cystic neoplasm (MCN) in 2000, based on presence ovarian-type stroma, its clinical features became more apparent. Surgery for MCN, which primarily affects middle-aged women with long life expectancies, is likely to negatively impact patient's quality life. Although recent studies have reported low proportion advanced neoplasia among resected MCN (≤15%), many clinicians still recommend surgery patients presumed...
Abstract Most cancer mutation profiling studies are laboratory-based and lack direct clinical application. For use, it is necessary to focus on key genes integrate them with relevant variables. We aimed evaluate the prognostic value of dosage KRAS G12 mutation, a pancreatic ductal adenocarcinoma (PDAC) variant investigate biological mechanism prognosis associated mutation. In this retrospective cohort study, we analyzed 193 surgically treated patients PDAC between 2009 2016. RNA,...
Background: Pancreatic cancer is a highly aggressive malignancy with poor prognosis. Neoadjuvant chemotherapy (NAC) increasingly used to improve survival in patients pancreatic cancer; however, it often results nutritional deterioration, which may negatively impact patient outcomes. Therefore, this study aimed assess the effect of changes status on long-term outcomes who underwent curative surgery after NAC. Methods: This retrospective single-center included 148 NAC between 2010 and 2020....
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a malignant form of cancer with the worst survival rate and an extremely low response to treatments. The development molecular characterization pancreatic cell lines (PCCLs) are essential for studying biology highly aggressive adenocarcinoma. Methods We applied whole exome sequencing (WES) RNA-seq identify characteristics 26 newly established PCCLs. Eighteen clinically relevant anti-cancer drugs were used assess heterogeneous...
Abstract Background With the evolving treatment paradigms for pancreatic cancer, there is an increasing need reliable markers to evaluate effectiveness of preoperative chemotherapy. Due limitations current indicators, this study aimed prognostic value metabolic response based on changes in maximum standardized uptake (SUV max ) fluorine‐18‐fluorodeoxyglucose positron emission tomography. Methods This included 210 patients with cancer who underwent post‐chemotherapy curative surgery between...
Objective: To evaluate the prognostic impact of resection margin in distal cholangiocarcinoma (dCC). Background: Due to relatively low prevalence dCC Western countries and use various definitions status, bile duct status remains unclear. Methods: This study included consecutive patients who underwent curative surgery were diagnosed with between 2000 2022. Bile was classified as clear margin, low-grade dysplasia (LGD), high-grade (HGD), tumor present. Results: Of 587 patients, 506 (86.2%), 17...
Introduction: The applicability of neoadjuvant treatment (NAT) for resectable pancreatic ductal adenocarcinoma (PDAC) has arisen, however, high-level evidence is lacking. This study aimed to explore patient subgroups with high-risk PDAC selecting candidates who may benefit from NAT. Methods: 1,132 patients or borderline underwent surgery between 2007 and 2021 were retrospectively reviewed. Patients without contact major vessels (R-no contact) (n=651), portal vein superior mesenteric (PV/SMV)...
In the era of effective chemotherapy on pancreatic ductal adenocarcinoma (PDAC) with distant metastasis, data effects metastatectomy are lacking. So, we investigated effect survival after metastasis in PDAC patients isolated lung metastasis. This retrospective study analyzed 1342 who were histologically diagnosed from January 2007 to December 2018, which 83 had pulmonary Additionally, 4263 extracted National Cancer Database (NCDB) and analyzed. Log-rank test Kaplan−Meier analysis used...
Circulating tumor DNA (ctDNA) is a promising biomarker for early detection and minimal residual disease (MRD) assessment in early-stage cancer, but quantifying minute amounts of ctDNA challenging well-designed studies on cancer are still lacking. Here, we adapted sensitive next-generation sequencing (NGS) technology performed parallel analysis pre- postoperative matched tissues prospective cohort patients with resectable pancreatic ductal adenocarcinoma (PDAC).In total, 70 consecutive...
Abstract Background Neoadjuvant treatment (NAT) is standard for borderline resectable pancreatic cancer (BRPC). However, consensus lacking on the optimal surgical timing patients with BRPC undergoing NAT. The aim of this study was to investigate long‐term outcomes NAT and suggest resection timing. Methods Prospectively collected data 282 between January 2007 December 2019 were retrospectively reviewed. There 164 who underwent followed by surgery, 45 chemotherapy only, 73 upfront surgery....
Background: R0 rates have increased as neoadjuvant treatment (NAT) has become the primary for pancreatic ductal adenocarcinoma (PDAC) with venous involvement, suggesting a decrease in tumor infiltration. The aim of this study was to investigate clinical outcomes preserving portal/superior mesenteric vein (PV/SMV) during pancreaticoduodenectomy (PD) PDAC patients who underwent NAT. Material and Methods: 113 resectable borderline involvement responded NAT curative PD between 2012 2022 were...
Abstract Background Thoracic epidural analgesia (TEA), once the standard for pain management in major abdominal operations, is associated with postoperative complications, making preperitoneal continuous wound infiltration (CWI) a promising alternative. This study aimed to compare effectiveness of CWI and TEA managing after open pancreatoduodenectomy. Methods In single-centre, randomized, open-label non-inferiority trial, adult patients undergoing elective pancreatoduodenectomy were assigned...
In an era of more effective chemotherapy for pancreatic ductal adenocarcinoma (PDAC), the paradigm local treatment is changing. However, efficacy in patients with isolated liver metastasis remains unclear. Therefore, we aimed to evaluate effectiveness pancreatectomy ± (cytoreductive surgery) PDAC synchronous metastasis.In total, 239 were extracted from Seoul National University Hospital (SNUH). For comparison, another 12 637 Cancer Database (NCDB). Propensity score matching was performed...
The aim of this study was to investigate the oncologic safety and identify potential candidates for proximal gastrectomy (PG) in upper third advanced gastric cancer (AGC) esophagogastric junction (EGJ) cancers.Among 5,665 patients who underwent adenocarcinoma between January 2011 December 2017, 327 total with standard lymph node (LN) dissection AGC Siewert type II EGJ cancers were enrolled. We analyzed correlation metastatic rates distal LNs (No. 4d, 5, 6, 12a) around lower part stomach...
Abstract There is an increasing demand and need for patients caregivers to actively participate in the treatment process. However, when there are unexpected findings during pediatrics surgery, access restrictions operating room may lead a lack of understanding medical condition, as forced indirectly hear about it. To overcome this, we designed tele-consent system that operates through specially constructed mixed reality (MR) environment surgery. We enrolled 11 with unilateral inguinal hernia...