A5084395887- Microtubule and mitosis dynamics
- Developmental Biology and Gene Regulation
- Zebrafish Biomedical Research Applications
- Neurogenesis and neuroplasticity mechanisms
- Protist diversity and phylogeny
- Congenital heart defects research
- Crystallization and Solubility Studies
- Retinal Development and Disorders
- Wnt/β-catenin signaling in development and cancer
- Cellular transport and secretion
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Photoreceptor and optogenetics research
- Asymmetric Synthesis and Catalysis
- Network Traffic and Congestion Control
- Cancer-related Molecular Pathways
- Software-Defined Networks and 5G
- Metalloenzymes and iron-sulfur proteins
- Traditional and Medicinal Uses of Annonaceae
- Neuroinflammation and Neurodegeneration Mechanisms
- Photosynthetic Processes and Mechanisms
- Ocular Oncology and Treatments
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
Nagoya University
2016-2025
Osaka University
1999-2023
Brigham and Women's Hospital
2022
Matsue Red Cross Hospital
2020
Suita Municipal Hospital
2020
NTT (Japan)
2003-2019
National Institute of Advanced Industrial Science and Technology
1993-2019
Nagoya Institute of Technology
1991-2018
Kansai University of Nursing and Health Sciences
2018
University of Health Science
2018
In amphibian and teleost embryos, the dorsal determinants (DDs) are believed to be initially localized vegetal pole then transported prospective side of embryo along a microtubule array. The DDs known activate canonical Wnt pathway thereby promote expression genes that induce organizer. Here, by identifying locus maternal-effect ventralized mutant tokkaebi, we show Syntabulin, linker kinesin I motor protein, is essential for determination in zebrafish. We found syntabulin mRNA during...
This paper presents wireless OAM (orbital angular momentum) and OAM-MIMO (multi-input multi-output) multiplexing in a 28 GHz frequency band. We have implemented transmission (Tx) reception (Rx) antennas consisting of multiple uniform circular arrays (UCAs) to confirm the feasibility. Each UCA can concurrently transmit or receive five mode signals (0, ±1, ±2). Using antennas, we rectified mode-selective Rx SNR degradation caused by inherent nature beams. With combination antenna selection...
Neural crest cells generate numerous derivatives, including pigment cells, and are a model for studying how fate specification from multipotent progenitors is controlled. In mammals, the core gene regulatory network melanocytes (their only cell type) contains three transcription factors, Sox10, Pax3 Mitf, with latter considered master regulator of melanocyte development. teleosts, which have to four types (melanophores, iridophores xanthophores, plus leucophores e.g. in medaka), networks...
The zebrafish mutant ogon (also called mercedes and short tail) displays ventralized phenotypes similar to the chordino (dino) mutant, in which gene for Bmp antagonist Chordin is mutated. We isolated responsible by a positional cloning strategy found that locus encodes homolog of Secreted Frizzled (Sizzled), has sequence similarity Wnt receptor, Frizzled. Unlike other secreted Frizzled-related proteins (sFrps) inhibitor Dickkopf1, misexpression Ogon/Sizzled dorsalized, but did not...
The effects of vanadate on the kinetics ATP binding and hydrolysis by Tetrahymena 30 S dynein were examined presteady state kinetic analysis.Up to a concentration 400 PM, did not inhibit rate or amplitude binding-induced dissociation microtubule-dynein complex measured stopped flow light-scattering methods.Chemical quench experiments showed that (80 PM) alter transients, but steady was blocked immediately after single turnover ATP.Preincubation enzyme with ADP inhibited both hydrolysis.These...
Fibroblast growth factor (Fgf) and retinoic acid (RA) signals control the formation anteroposterior patterning of posterior hindbrain. They are also involved in development processes other regions embryo. Therefore,responsiveness to Fgf RA must be controlled a context-dependent manner. Inhibiting caudal-related genes cdx1a cdx4 zebrafish embryos caused ectopic expression that normally expressed hindbrain anterior spinal cord, motor commissure neurons posteriormost neural tissue....
Neurons have highly polarized structures that determine what parts of the soma elaborate axon and dendrites. However, little is known about mechanisms establish neuronal polarity in vivo . Cerebellar Purkinje cells extend a single primary dendrite from ramifies into branched dendritic arbor. We used zebrafish cerebellum to investigate by which acquire these characteristics. To examine morphogenesis individual cells, we marked cell membrane using cell-specific promoter drive membrane-targeted...
Precise control of neuronal differentiation is necessary for generation a variety neurons in the forebrain. However, little known about transcriptional cascades, which initiate forebrain neurogenesis. Here we show that zinc finger genes Fezf1 and Fezf2, encode repressors, are expressed early neural stem (progenitor) cells neurogenesis mouse dorsal telencephalon. Fezf1- Fezf2-deficient forebrains display upregulation Hes5 downregulation neurogenin 2, to be negatively regulated by Hes5. We...
Abstract A series of novel optically active [5]helicene-derived phosphine ligands ( L1 , with a 7,8-dihydro[5]helicene core structure- and L2 fully aromatic [5]helicene structure) were synthesized. Despite their structural similarities, exhibit particularly different characteristics in use as chiral ligands. was highly effective the asymmetric allylation indoles 1,3-diphenylallyl acetate (up to 99% ee), etherification alcohols 96% ee). In contrast, stereocontrol helical chirality...