A5082219352- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Lung Cancer Research Studies
- Cerebral Venous Sinus Thrombosis
- Glaucoma and retinal disorders
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Ocular Diseases and Behçet’s Syndrome
- Retinal Diseases and Treatments
- Diversity and Career in Medicine
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Hallucinations in medical conditions
- Epilepsy research and treatment
- Chemical synthesis and alkaloids
- Management of metastatic bone disease
- Skin and Cellular Biology Research
- Healthcare Operations and Scheduling Optimization
- Radiopharmaceutical Chemistry and Applications
- Rabbits: Nutrition, Reproduction, Health
- Polyomavirus and related diseases
- Plant Virus Research Studies
- Biomedical Research and Pathophysiology
Columbia University
2015-2022
NewYork–Presbyterian Hospital
2020-2022
New York Hospital Queens
2022
Columbia University Irving Medical Center
2014-2021
Insall Scott Kelly Institute
2018-2019
Columbia College
2017
Royal College of Physicians
2017
Sylvester Comprehensive Cancer Center
2015
Herbert Irving Comprehensive Cancer Center
2015
Neurological Surgery
2015
We investigated effects of genetic alterations in epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and Kirsten rat sarcoma viral oncogene homolog (KRAS) on overall survival (OS) local control after stereotactic radiosurgery for brain metastases non-small cell lung cancer (NSCLC).A cohort 89 out 262 NSCLC patients (2003-2013) treated with gamma knife had genotyping available were selected as our study population.Median follow-up was 12 months. Median OS rates the...
To report spectral domain optical coherence tomography and fundus autofluorescence documentation of late stage macular findings associated with Sjogren-Larsson Syndrome in three adult siblings.Three siblings underwent ophthalmic examination imaging.Crystalline maculopathy subretinal deposits, presumably lipofuscin accumulation, atrophy were present varying degrees all siblings.In adults Syndrome, crystalline retinopathy can progress to the appearance accumulation.
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease most common in immunodeficient patients. It occurs due to reactivation of the John Cunningham Virus (JCV) and carries poor prognosis, with median life expectancy 6 months. We report case 66-year-old man history HCV related cirrhosis (HCV) hepatocellular carcinoma (HCC) who was found have PML setting negative viral load CSF CD4+ >200. He initially presented two weeks mild confusion word-finding difficulty...
Despite the paucity of supporting data, it has generally been held that proptosis in thyroid eye disease (TED) may provide relative protection from compressive optic neuropathy (CON) by producing spontaneous decompression. The objective this study was to investigate phenomenon patients with bilateral TED-CON.We retrospectively reviewed charts 67 (134 orbits) TED-CON at Columbia-Presbyterian Medical Center. Significant asymmetric (Hertel) defined as ≥ 2 mm. CON first, presence an afferent...
The energy index (EI) is a measure of dose homogeneity within target volume calculated by the integral divided product prescription and tumor volume.To assess whether higher EI associated with greater local control for brain metastases (BMs) treated Gamma Knife radiosurgery (GKRS).We reviewed all patients GKRS BM at our institution between January 2009 February 2014. Data on dose, isodose line, minimum mean volume, were collected. Tumor response was assessed reviewing follow-up imaging...
1. Many of the responses plain muscle to drugs that are frequently described as transient appear so because experimental conditions record only part response. 2. The phasic observed can be explained on assumption drug produces some rapid change, and other changes, which proceed more slowly, modify initial 3. These apparent actions do not necessitate potential action drugs. My thanks due Prof. A. J. Clark for assistacnce advice in carrying out this research.
Tacrolimus is a commonly used immunosuppressant medication after lung transplantation. In rare cases, tacrolimus causes medication-induced optic neuropathy (TON) that can lead to significant vision loss.In this series, we describe three cases of TON, 1-10 years use. Two patients were young (22yr and 33yr) females with cystic fibrosis. The last case was 65yr male idiopathic pulmonary 2/3 serum levels normal. Visual acuity ranged from 20/20 20/300, loss occurred acutely sub-acutely, over span...
This report describes a case of retinal vasculitis in patient with autoimmune lymphoproliferative syndrome (ALPS). A 13-year-old girl undergoing work-up for immune dysregulation was referred vasculitis. The asymptomatic on presentation, but her examination remarkable areas outer and choriocapillary loss focal vascular inflammation. Subsequent bone marrow biopsy genetic sequencing revealed diagnosis ALPS, she started immunosuppression. Most cases ocular ALPS have anterior involvement, changes...
Abstract Background In resident family medicine practices, a >20% no-show rate is common, often resulting in suboptimal care. Few studies have evaluated ophthalmology practices similar fashion. The objective of this study was to determine rates and factors related missed appointments resident-based clinic. Methods We reviewed 19,237 de-identified over one academic year. Appointments were divided into general clinic visits subspecialty (these two clinics function separately at our...
This case series details macular findings in three female siblings who were found to be carriers of a previously unreported splice mutation GPR143 (X-linked ocular albinism [OA1]). Presumed lyonization is responsible for both the subtle and varied OA1 carriers, even among siblings, especially patients with darker skin pigmentation. In this series, we used green-light autofluorescence reveal subfoveal involvement optical coherence tomography angiography uncover narrowing foveal avascular...
Few studies have evaluated the methodology by which radiation therapy (RT) for thyroid eye disease and compressive optic neuropathy is performed. The objective of this study was to retrospectively review our experience from a planning standpoint determine whether current treatment methods provide adequate dose target collateral structures.A retrospective 52 patients (104 orbits) with bilateral treated RT (20 Gy in 10 fractions) at institution. plans were analyzed volumes doses. Visual...
Abstract Background The American Academy of Ophthalmology, in conjunction with the Accreditation Council Graduate Medical Education (ACGME), has mandated creation a linked ophthalmology internship year for all programs by 2021. This mandate provides unique opportunity to tailor curriculum specific trainee. study reports results national survey residents and fellows regarding relevance applicability extramural content their training. Methods Using online portal SurveyMonkey, an anonymous was...
We sought to investigate the oncologic outcome of brain metastases (BM) patients treated with Gamma Knife Radiosurgery (GKRS) based on number metastases. The Columbia University Medical Center database was queried for GKRS from 1998 2013. There were 526 (233 men) median age 62 years. Patients divided into two groups; group 1 included 1-3 BM and 2 4-12 BM. Primary cancers 257 (48.7%) lung, 102 (19.3%) breast, (11.7%) melanoma, 40 (7.6%) renal cell, 29 (5.5%) gastrointestinal, 36 (7.2%) other....
Purpose To assess the evolution of proptosis asymmetry during active phase bilateral thyroid eye disease (TED).Methods A retrospective study was conducted on patients with bilateral, TED. Patients were measured by a single observer, using Hertel exophthalmometry from time initial presentation, TED, to stable phase, 24-months later. Asymmetric defined as >2 mm intra-orbital difference in measurements.Results Fifty-one enrolled. presented at mean 1.1 ± 2.9 months following onset TED symptoms....