A5061741688- Radiation Therapy and Dosimetry
- Effects of Radiation Exposure
- DNA Repair Mechanisms
- Nutrition, Genetics, and Disease
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Carbon Nanotubes in Composites
- Phagocytosis and Immune Regulation
- Birth, Development, and Health
- Cancer, Hypoxia, and Metabolism
- Polysaccharides and Plant Cell Walls
- Plant Genetic and Mutation Studies
- Cancer-related Molecular Pathways
- Dietary Effects on Health
- Neuroblastoma Research and Treatments
- Radiation Dose and Imaging
- Radioactive contamination and transfer
- Health, Environment, Cognitive Aging
- Cancer, Stress, Anesthesia, and Immune Response
- Radioactivity and Radon Measurements
- Nanoplatforms for cancer theranostics
- Childhood Cancer Survivors' Quality of Life
National Institutes for Quantum Science and Technology
2018-2024
Tokyo Metropolitan Industrial Technology Research Institute
2019
Japan Atomic Energy Agency
2019
Hiroshima University
2019
Central Research Institute of Electric Power Industry
2019
Kyorin University
2019
National Center of Radiobiology and Radiation Protection
2016
Ibaraki University
2015
Tokyo Gakugei University
2000
Monitoring mice exposed to carbon ion radiotherapy provides an indirect method evaluate the potential for second cancer induction in normal tissues outside target volume, since such estimates are not yet possible from historical patient data. Here, male and female B6C3F1 were given single or fractionated whole-body exposure(s) a monoenergetic beam at Heavy Ion Medical Accelerator Chiba, Japan, matching radiation quality delivered tissue ahead of tumour volume (average linear energy transfer...
Background/Aim: Progress in cancer treatment and diagnosis has made second after medical radiation exposure a particular concern among childhood survivors. Calorie restriction (CR) is broadly effective prevention strategy, although its effects on radiation-induced intestinal tumours are unclear. Here we examined the cancer-preventative efficacy of CR diet at different starting ages induction mice. Materials Methods: Male C3B6F1 Apc<sup>Min/+</sup> mice were irradiated with 0 or 2 Gy X-rays...
To study the signal transduction of cytokinins, we characterized cytokinin-binding proteins (CBPs) isolated from tobacco callus Nicotiana tabacum. Two high-affinity CBPs, CBP1 and CBP2, were soluble fraction BY-2 cells by anion exchange chromatography on a DEAE-cellulose column affinity benzyladenine (BA)-linked Sepharose 4B column. Cytokinin-binding activity was determined equilibrium dialysis method. The degree purification CBP2 270 600-fold, respectively. These had molecular masses 34 kDa...
Calorie restriction (CR) suppresses not only spontaneous but also chemical- and radiation-induced carcinogenesis. Our previous study revealed that the cancer-preventive effect of CR is tissue dependent does effectively prevent development thymic lymphoma (TL). We investigated association between genomic alterations resulting TLs to clarify underlying resistance mechanism. were obtained from new experiments, in which B6C3F1 mice exposed radiation at 1 week age fed with a or standard (non-CR)...
Abstract The risk of cancer due to exposure ionizing radiation is higher in infants than adults. In a previous study, the effect adult-onset calorie restriction (CR) on carcinogenesis mice after early-life X-rays was examined (Shang, Y, Kakinuma, S, Yamauchi, K, et al. Cancer prevention by infant B6C3F1 male mice. Int J Cancer. 2014; 135: 1038-47). results showed that tumor frequency reduced CR group. However, mechanism suppression not yet clear. this we effects radiation-induced mutations...
The risk of radiation-induced carcinogenesis depends on age at exposure. We previously reported principal causative genes in lymphomas arising after infant or adult exposure to 4-fractionated irradiation as Pten Ikzf1, respectively, suggesting that cells with mutation these might be the origin depending Here, we clarified age-dependent differences thymus-cell dynamics mice during initial post-irradiation period. thymocyte number initially decreased, followed by two regeneration phases....
Carbon ion radiotherapy (CIRT) for pediatric cancer is currently limited because of the unknown risk induction secondary cancers. Medulloblastoma Ptch1+/- mice offers a unique experimental system radiation-induced carcinogenesis, in which tumors are classified into spontaneous and subtypes based on their features loss heterozygosity (LOH) that affect wild-type Ptch1 allele. The present study aims to investigate young carcinogenic effect, its age dependence, low-linear energy transfer (LET,...
実効線量，重み付け臓器線 量などの基礎用語と放射線が DNA を傷つける原理や線 量に対する