Most popular vegetables and fruits their corresponding soil from the sub-urban industrial area of Bangladesh were collected concentration carcinogenic (Pb, As, Cd) non-carcinogenic (Fe, Co, V, Cu, Cr, Zn, Mn, Ni) heavy metals was determined. Health risk evaluated by estimating daily metal intake computing cancer non-cancer risks (ILCR THQ) using probabilistic assessment model US-EPA. Heavy in varied with vegetable species as well types. Higher Fe, Pb observed consumption root leafy...

Temperature dependences of the hole concentration and Hall mobility in Mg-doped GaN Al0.08Ga0.92N grown by metalorganic vapor phase epitaxy were measured van der Pauw method over a wide temperature range from 100 to 500 K. Assuming that effective mass holes is equal GaN, activation energy Mg shallow acceptor estimated be about 35 meV deeper than GaN.

We fabricated single-crystal ZnO nanowires at a low temperature of 500 °C without using any metal catalysts via the simple thermal oxidation metallic Zn precursors. Scanning electron microscopy and high-resolution transmission (HRTEM) studies showed that with orientation-selectivity grew laterally along sides hexagonal-shaped matrix transformed from It was found 〈112̄0〉 direction were single crystals by HRTEM study. Typically, lengths ranged 0.5 to 3 μm their mean diameter 20±5 nm....

Intracellular thiols like L-cystine and play a critical role in the regulation of cellular processes. Here we show that Escherichia coli has two transporters, symporter YdjN ATP-binding cassette importer FliY-YecSC. These proteins import L-cystine, an oxidized product from periplasm to cytoplasm. The YdjN, which is expected be new member regulon, low affinity transporter (Km = 1.1 μM) mainly involved uptake outside as nutrient. E. only importers because ΔydjNΔyecS mutant cells are not...

Abstract Glucometers are also widely used in diabetes research conducted using animal models. However, the appropriateness of measuring blood glucose levels glucometers models remains unclear. In this study, we evaluated consistency between measured by 11 and plasma a laboratory biochemical test samples collected retro-orbital sinus puncture or tail-tip amputation. both obtained those amputation, 10 yielded higher values, while 1 lower than values test, differences being direct proportion to...

Abstract Currently, although >10 antibody−drug conjugates (ADCs) are available in the market, most of them (10 ADCs) have broad drug distribution, thereby potentially limiting their therapeutic index. The ADC industry is shifting from random conjugation technology to site‐specific overcome this issue. Enzymatic a promising cutting‐edge owing its mild conditions. This review discussed enzymatic strategies for producing ADCs via modifying native antibodies without using tag moiety. We...

Enzyme-mediated site-specific protein modification is gaining attention in biopharmaceuticals due to its high specificity and mild conditions. Lipoic acid ligase A (LplA) has been widely studied for conjugating short-chain fatty acids lysine residues, traditionally using LAP tags. Recent advances have enabled tag-free LplA modifications, expanding applications antibody-drug conjugates (ADCs) beyond. This study investigates the selective of Lys188 trastuzumab by LplA. Spatial analysis...

To compare the efficacy and safety of these two agents impact on surrogate markers related to diabetic complications in Japanese type 2 patients.In a multicenter, open-label trial, 130 patients whose diabetes had been inadequately controlled (HbA1c, 6.9-9.5%) with metformin and/or sulphonylurea were randomly assigned sitagliptin group (50 mg/day) or pioglitazone (15 followed up for 24 weeks. At 16 weeks, if patient's HbA1c level was ≥6.5%, dose increased 100 30 mg/day, respectively. Main...

Metformin has been widely used for the treatment of type 2 diabetes. However, effect metformin on pancreatic β-cells remains controversial. In this study, we investigated impacts with in a mouse model fed high-fat diet (HFD), which triggers adaptive β-cell replication. An 8-wk improved insulin resistance and suppressed compensatory hyperplasia induced by HFD-feeding. contrast, increment mass arising from 60 wk HFD feeding was similar mice treated those without metformin. Interestingly,...

Abstract Enzymatic modifications of proteins are great interest in the pharmaceutical industry as it enables production homogeneous protein conjugates such antibody‐drug conjugates, which considered to be promising for cancer medicine. Several biotechnology companies have established proprietary conjugation technologies using specific enzymes. Most enzymatic require use tags and enzyme‐recognition moieties. Therefore, site‐specific “tag‐free” required avoid time‐consuming process installing...

Recent studies have identified interstitial deletions in the cancer genome as a radiation-related mutational signature, although most of them do not fall on driver genes. Pioneering field indicated presence loss heterozygosity (LOH) spanning Apc subset sporadic and radiation-induced intestinal tumors ApcMin/+ mice, albeit with substantial which LOH was detected; whether copy number losses accompany such has also been unclear. Herein, we analyzed C3B6F1 mice that were either left untreated or...

Abstract Superconducting circuits offer a scalable platform for the construction of large-scale quantum networks, where information can be encoded in multiple temporal modes propagating microwaves. Characterization such microwave signals with method extendable to an arbitrary number single detector and demonstration their phase-robust nature are great interest. Here, we show on-demand generation Wigner tomography time-bin qubit superconducting circuit electrodynamics architecture. We perform...

Diabetes therapy that not only lowers glucose levels but also lengthens life spans is required. We previously demonstrated DPP-4 inhibition ameliorated β cell apoptosis and adipose tissue inflammation in cell-specific glucokinase haploinsufficient mice fed a diet containing combination of sucrose linoleic acid (SL).In this study, we investigated the effects obese diabetic db/db an SL or control oleic (SO). examined IRS-1-deficient SO as model insulin resistance.DPP-4 efficiently increases...

The evolution of photocurrent in time under ultraviolet (UV) irradiation free-standing diamond thin films, prepared by chemical vapor deposition method, have been observed. A significant enhancement the photosensitivity visible-near-infrared region UV illuminated samples obtained. linear dependence relative change on radiant intensity found. photoconductivity spectra investigated energy range 1–6.2 eV. results investigation shown that films possess similar properties as radiation damaged...

Background/Aim: Progress in cancer treatment and diagnosis has made second after medical radiation exposure a particular concern among childhood survivors. Calorie restriction (CR) is broadly effective prevention strategy, although its effects on radiation-induced intestinal tumours are unclear. Here we examined the cancer-preventative efficacy of CR diet at different starting ages induction mice. Materials Methods: Male C3B6F1 Apc^Min/+ mice were irradiated with 0 or 2 Gy X-rays...

Abstract Allergic contact dermatitis is a serious health problem. There need to identify and characterize skin sensitization hazards, particularly with respect relative potency, so that accurate risk assessments can be developed. For these purposes the murine local lymph node assay (LLNA) was Here, we have investigated further modification of this assay, non‐radioisotopic LLNA, which in place tritiated thymidine measure cell proliferation employs incorporation 5‐bromo‐2'‐deoxyuridine. Using...

Sulfur is an essential element for growth and many physiological functions. As sulfur sources Escherichia coli related bacteria, specific transporters import various sulfur-containing compounds from the environment. In this study, we identified characterized alternative function of cystine transporter YdjN in E. as a S-sulfocysteine, intermediate assimilatory cysteine biosynthesis that used source We also demonstrated transport S-sulfocysteine via depends on transcriptional regulator CysB,...

Lung is one of the high-risk organs for radiation-induced carcinogenesis, but risk secondary lung-cancer development after particle-beam therapy and underlying mechanism(s) remain to be elucidated. To investigate effects radiation on adjacent normal tissues during cancer therapy, 7-week-old male female B6C3F1 mice were irradiated with 0.2–4 Gy gamma rays (for comparison), carbon ions (290 MeV/u, linear energy transfer 13 keV/µm), or fast neutrons (0.05–1 Gy, mean energy, ∼2 MeV), lung-tumor...