A5074154373- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Prostate Cancer Treatment and Research
- Radiation Therapy and Dosimetry
- Management of metastatic bone disease
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
- Endometrial and Cervical Cancer Treatments
- Advances in Oncology and Radiotherapy
- Prostate Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced X-ray and CT Imaging
- Global Cancer Incidence and Screening
- Organ Transplantation Techniques and Outcomes
- Gastric Cancer Management and Outcomes
- Multiple and Secondary Primary Cancers
- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
Washington University in St. Louis
2019-2025
University of Washington
2024
Tulane University
2016-2023
Barnes-Jewish Hospital
2020-2021
Jewish Hospital
2020
Cedars-Sinai Medical Center
2020
Abstract Purpose High‐quality CBCT and AI‐enhanced adaptive planning techniques allow CBCT‐guided stereotactic radiotherapy (CT‐STAR) to account for inter‐fractional anatomic changes. Studies of intra‐fractional respiratory motion management with a surface imaging solution CT‐STAR have not been fully conducted. We investigated in breath‐hold Ethos‐based CT‐SBRT (stereotactic body non‐adaptive radiotherapy) using optical combined onboard CBCTs. Methods Ten cancer patients mobile lower lung or...
PurposeHerein we report the clinical and dosimetric experience for patients with metastases treated palliative simulation-free radiation therapy (SFRT) at a single institution.Methods MaterialsSFRT was performed institution. Multiple fractionation regimens were used. Diagnostic imaging used treatment planning. Patient characteristics as well planning time points collected. A matched cohort of conventional computed tomography simulation (CTRT) acquired to evaluate differences in time. SFRT...
Abstract Background Online adaptive stereotactic radiotherapy allows for improved target and organ at risk (OAR) delineation inter-fraction motion management via daily planning. The use of SBRT the treatment pancreatic cancer (performed until now using only MRI or CT on rails-guided radiotherapy), has yielded promising outcomes. Herein we describe first reported case cone beam CT-guided (CT-STAR) cancer. Case presentation A 61-year-old female with metastatic presented durable palliation a...
A novel O-ring gantry can deliver stereotactic body radiation therapy (SBRT) with artificial intelligence-facilitated, CT-guided online plan adaptation. It gates mobile targets by optically monitoring skin surface motion. However, this gating solution has not been clinically validated. We conducted a trial to evaluate the feasibility of optical surface-guided for patients upper abdominal or lower thoracic malignancies treated SBRT on platform (NCT05030454).Ten who were prescribed target and...
Background and PurposeImproved hounsfield-unit accuracy of on-board imaging may lead to direct-to-unit treatment approaches We aimed demonstrate the feasibility using only a diagnostic (dx) computed tomography (CT)-defined target pre-plan in an silico study simulation-free abdominal stereotactic adaptive radiotherapy (ART).Materials MethodsEight patients with sites (five pancreatic cancer, three oligometastases) were treated integrated O-Ring gantry system. Each patient's was delineated on...
Our institution was the first in world to clinically implement MR-guided adaptive radiotherapy (MRgART) 2014. In 2021, we installed a CT-guided (CTgART) unit, becoming one of clinics build dual-modality ART clinic. Herein review factors that lead development high-volume program and treatment census over an initial, one-year period.The clinical service at our is enabled with both MRgART (MRIdian, ViewRay, Inc, Mountain View, CA) CTgART (ETHOS, Varian Medical Systems, Palo Alto, platforms. We...
We conducted a prospective pilot study evaluating the feasibility of same day MRI-only simulation and treatment with MRI-guided adaptive palliative radiotherapy (MAP-RT) for urgent indications (NCT#03824366). All (16/16) patients were able to complete 99% their first on-table attempted fractions, no grades 3-5 toxicities occurred.
Magnetic resonance (MR) image (MRI) guided radiation therapy (MRgRT) confers superior daily soft-tissue target visualization for many anatomic sites compared with traditional computed tomography (CT)–based and is increasingly used to manage inter- intrafraction motion in a variety of cancer diagnoses.1,2 There growing evidence that MRgRT may be improve the dosimetric therapeutic index treatment through improved setup accuracy, opportunity online plan adaptation, real-time cine MRI tumor...
Stereotactic body radiotherapy (SBRT) to the central and ultra-central thorax is associated with infrequent but potentially serious adverse events. Adaptive SBRT, which provides more precise treatment planning inter-fraction motion management, may allow delivery of ablative doses tumors effective local control improved toxicity profiles. Herein, we describe first reported case cone beam computed tomography (CBCT)-guided stereotactic adaptive (CT-STAR) in non-small cell lung cancer (NSCLC) a...
Abiraterone is an important agent in the treatment of advanced prostate cancer. Early changes prostate-specific antigen while on abiraterone patients with metastatic castrate-resistant cancer potentially have financial and health implications for patients. Limited data available early change subsequent survival given phase III trials did not measure before 12 weeks.A single-center retrospective study was performed. Metastatic treated (without prior enzalutamide) at Tulane Cancer Center were...
Spatially fractionated radiation therapy is hypothesized to allow for safe, hypofractionated, dose- escalated large tumors.1-3 can be delivered in a grid-like pattern (ie, GRID) using 3-dimensional conformal planning techniques. It also intensity modulated lattice therapy). Lattice delivers low dose gross tumor volume (GTV) with high spherical vertices spaced within the tumor, which has previously been described small case series of patients gynecologic and other malignancies.
BACKGROUND: Short-course radiation therapy and consolidation chemotherapy with nonoperative intent has emerged as a novel treatment paradigm for patients rectal cancer, but there are no data on the predictors of clinical complete response. OBJECTIVE: Evaluate response survival. DESIGN: Retrospective cohort. SETTINGS: National Cancer Institute–designated cancer center. PATIENTS: Patients stage I to III adenocarcinoma treated between January 2018 May 2019 (n = 86). INTERVENTIONS: followed by...
Introduction: Despite advances and new treatment options, advanced urothelial carcinoma (aUC) remains very challenging to treat has a poor prognosis. However, deeper knowledge of the molecular landscape aUC enabled identification potential biologic drivers, putative biomarkers, therapeutic targets. The purpose this review is discuss evolving field precision oncology emerging biomarkers in aUC.Areas covered: This discusses current landscape, strategies, targets future directions therapy...