A5068785172- FOXO transcription factor regulation
- DNA Repair Mechanisms
- Cancer Mechanisms and Therapy
- Microtubule and mitosis dynamics
- Hemoglobin structure and function
- CRISPR and Genetic Engineering
- Erythrocyte Function and Pathophysiology
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Hippo pathway signaling and YAP/TAZ
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Heat shock proteins research
- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- Space Satellite Systems and Control
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Cervical Cancer and HPV Research
- RNA and protein synthesis mechanisms
- Spacecraft Dynamics and Control
- Sirtuins and Resveratrol in Medicine
- Spacecraft Design and Technology
University of Illinois Chicago
2017-2023
Indian Space Research Organisation
2023
University of Illinois Urbana-Champaign
2017-2022
Ashland (United States)
2017-2022
Illinois College
2017-2022
University of Delhi
2013-2021
Google (United States)
2016
The transcription factor Forkhead box M1 (FoxM1) is overexpressed in breast cancers and correlates with poor prognosis. Mechanistically, FoxM1 associates CBP to activate Rb repress transcription. Although the activating function of cancer has been well documented, significance its repressive activity poorly understood. Using CRISPR–Cas9 engineering, we generated a mouse model that expresses FoxM1-harboring point mutations block binding while retaining ability bind CBP. Unlike FoxM1-null...
Despite significant research, our understanding of the molecular mechanisms Human Papilloma Virus (HPV) induced cancers remains incomplete. Majority invasive cervical are caused by high-risk HPV 16 and 18. Two potent oncoproteins, E6 E7, promote human malignancies disrupting activities key regulators cell proliferation apoptosis. Recent investigations have identified hADA3, a transcriptional coactivator protein as target HPV16E6. However, mechanism degradation hADA3 its contribution in...
The forkhead box transcription factor FoxM1 is essential for hepatocellular carcinoma (HCC) development, and its overexpression coincides with poor prognosis. Here, we show that the mechanisms by which drives HCC progression involve overcoming inhibitory effects of liver differentiation gene FoxA2. First, expression patterns FoxA2 in human are opposite. We represses G1 phase. Repression phase important, as it capable inhibiting pluripotency genes expressed mainly S-G2 phases. Using a...
FoxM1b is a cell cycle-regulated transcription factor, whose over-expression marker for poor outcome in cancers. Its transcriptional activation function requires phosphorylation by Cdk1 or Cdk2 that primes Plk1, which triggers association with the co-activator CBP. also possesses repression function. It represses mammary differentiation gene GATA3 involving DNMT3b and Rb. We investigated what determines two distinct functions of FoxM1b: repression. show Rb binds to C-terminal domain FoxM1b....
<div>Abstract<p>The transcription factor Forkhead box M1 (FoxM1) is overexpressed in breast cancers and correlates with poor prognosis. Mechanistically, FoxM1 associates CBP to activate Rb repress transcription. Although the activating function of cancer has been well documented, significance its repressive activity poorly understood. Using CRISPR–Cas9 engineering, we generated a mouse model that expresses FoxM1-harboring point mutations block binding while retaining ability bind...
Supplementary Data from Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer
<div>Abstract<p>The transcription factor Forkhead box M1 (FoxM1) is overexpressed in breast cancers and correlates with poor prognosis. Mechanistically, FoxM1 associates CBP to activate Rb repress transcription. Although the activating function of cancer has been well documented, significance its repressive activity poorly understood. Using CRISPR–Cas9 engineering, we generated a mouse model that expresses FoxM1-harboring point mutations block binding while retaining ability bind...
Supplementary Data from Transcriptional Repression by FoxM1 Suppresses Tumor Differentiation and Promotes Metastasis of Breast Cancer
Abstract The pro-proliferation transcription factor FoxM1 is over-expressed mainly in high-grade cancers. However, the significance of its over-expression cancers, including poorly differentiated hepatocellular carcinoma (HCC), not known. Here we provide evidence for a causal role driving progression HCC. Immunohistochemical staining human HCC specimens revealed opposite expression patterns and liver differentiation genes FoxA1/A2. Moreover, using transgenic mouse model oncogenic Ras-driven...
ABSTRACT The fork-head box transcription factor FoxMl is essential for hepatocellular carcinoma (HCC) development and its overexpression coincides with poor prognosis. Here, we show that the mechanisms by which FoxM1 drives HCC progression involve overcoming inhibitory effects of liver differentiation gene FoxA2. First, expression patterns FoxA2 in human are opposite. We represses G1 phase, a phase cell cycle cells can undergo differentiation. Repression important, as it capable inhibiting...