A5013388065- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Colorectal Cancer Screening and Detection
- SARS-CoV-2 detection and testing
- vaccines and immunoinformatics approaches
- Global Cancer Incidence and Screening
- Cancer Genomics and Diagnostics
- Ethics in Clinical Research
- Inflammatory Bowel Disease
- Vector-borne infectious diseases
- Advances in Oncology and Radiotherapy
- Long-Term Effects of COVID-19
- CAR-T cell therapy research
- Mosquito-borne diseases and control
- Economic and Financial Impacts of Cancer
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Patient-Provider Communication in Healthcare
- Colorectal and Anal Carcinomas
- Socioeconomic Development in MENA
- Smart Grid Energy Management
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Gender Diversity and Inequality
Adaptive Biotechnologies (United States)
2020-2025
Freenome (United States)
2022-2025
NYU Langone Health
2024
T cells are involved in the early identification and clearance of viral infections also support development antibodies by B cells. This central role for makes them a desirable target assessing immune response to SARS-CoV-2 infection. Here, we combined two high-throughput profiling methods create quantitative picture T-cell SARS-CoV-2. First, at individual level, deeply characterized 3 acutely infected 58 recovered COVID-19 subjects experimentally mapping their CD8 through antigen stimulation...
BACKGROUNDMeasuring the immune response to SARS-CoV-2 enables assessment of past infection and protective immunity. induces humoral T cell responses, but these responses vary with disease severity individual characteristics.METHODSA receptor (TCR) immunosequencing assay was conducted using small-volume blood samples from 302 individuals recovered COVID-19. Correlations between magnitude neutralizing antibody (nAb) titers or indicators were evaluated. Sensitivity testing assessed compared...
While diagnostic, therapeutic, and vaccine development in the coronavirus disease 2019 (COVID-19) pandemic has proceeded at unprecedented speed, critical gaps our understanding of immune response to severe acute respiratory syndrome 2 (SARS-CoV-2) remain unaddressed by current diagnostic strategies.A statistical classifier for identifying prior SARS-CoV-2 infection was trained using >4000 SARS-CoV-2-associated T-cell receptor (TCR) β sequences identified comparing 784 cases 2447 controls...
T cells play a prominent role in orchestrating the immune response to viral diseases, but their clinical presentation and subsequent immunity SARS-CoV-2 infection remains poorly understood. As part of population-based survey municipality Vo', Italy, conducted after initial outbreak, we sampled cell receptor (TCR) repertoires population 2 months PCR followed up positive cases 9 15 later. At months, found that 97.0% (98 101) had elevated levels TCRs associated with SARS-CoV-2. frequency...
T cells are involved in the early identification and clearance of viral infections also support development antibodies by B cells. This central role for makes them a desirable target assessing immune response to SARS-CoV-2 infection. Here, we combined two high-throughput profiling methods create quantitative picture T-cell SARS-CoV-2. First, at individual level, deeply characterized 3 acutely infected 58 recovered COVID-19 subjects experimentally mapping their CD8 through antigen stimulation...
Objectives: To assess strategies for optimizing participation of underserved minorities in a blood-based early CRC detection test study (PREEMPT CRC; NCT04369053) at hospital serving primarily Black patients. Methods: Culturally sensitive, racially congruent research staff approached patients undergoing average-risk screening colonoscopy. Consent/study procedures were synchronized with clinical appointments. Enrolled and not-enrolled patient characteristics compared. Recruitment was compared...
ABSTRACT Background While diagnostic, therapeutic, and vaccine development in the COVID-19 pandemic has proceeded at unprecedented speed scale, critical gaps remain our understanding of immune response to SARS-CoV-2. Current diagnostic strategies, including serology, have numerous limitations addressing these gaps. Here we describe clinical performance T- Detect™ COVID, first reported assay determine recent or prior SARS-CoV-2 infection based on T-cell receptor (TCR) sequencing repertoire...
ABSTRACT Objectives The primary aim of this study is to increase our understanding the adaptive immune response SARS-CoV-2 virus by assaying peripheral repertoire for virus-associated T-cell receptors (TCRs). Secondary aims include identification and characterization SARS-CoV-2–specific B-cell (BCRs) monoclonal antibodies (mAbs) generated antibody-producing cells during after acute infection. Trial design ImmuneRACE a prospective, single group, multi-cohort, exploratory unselected eligible...
Abstract In viral diseases T cells exert a prominent role in orchestrating the adaptive immune response and yet comprehensive assessment of T-cell repertoire, compared contrasted with antibody response, after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is currently lacking. A prior population-scale study municipality Vo’, Italy, conducted initial SARS-CoV-2 outbreak uncovered high frequency asymptomatic infected individuals their transmission this town. Two months...
TruAB Discovery is an approach that integrates cellular immunology, high-throughput immunosequencing, bioinformatics, and computational biology in order to discover naturally occurring human antibodies for prophylactic or therapeutic use. We adapted our previously described pairSEQ technology pair B cell receptor heavy light chains of SARS-CoV-2 spike protein-binding derived from enriched antigen-specific memory cells bulk antibody-secreting cells. identified approximately 60,000 productive,...
ABSTRACT Lyme disease, the most common tick-borne illness in United States, is frequently caused by infection with Borrelia burgdorferi . Although early antibiotic treatment can prevent development of severe and late manifestations, diagnosis challenging patients who do not present a typical erythema migrans rash. To support disease such cases, guidelines recommend 2-tiered serologic testing. However, testing has numerous limitations, including ambiguity interpretation lower sensitivity...
Abstract Measuring the adaptive immune response to SARS-CoV-2 can enable assessment of past infection as well protective immunity and risk reinfection. While neutralizing antibody (nAb) titers are one measure protection, such assays challenging perform at a large scale longevity nAb is not fully understood. Here, we apply T-cell receptor (TCR) sequencing assay that be performed on small volume standard blood sample assess infection. Samples were collected from cohort 302 individuals...
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e13532 Background: Colorectal cancer (CRC) is a leading cause of mortality among Hispanic and Latino groups (Hispanic/Latinx). Despite making up 18.9% the U.S. population, Hispanic/Latinx representation only 2.3%-3.9% subjects in oncology trials, highlighting need for diversity CRC research. Freenome developing blood test (MyTectCRC) intended to provide convenient accessible option screening. Its clinical validation will be supported by PREEMPT CRC, prospective multi-center observational...
1607 Background: Based on the 2022 census, 20% of U.S. population lives in rural areas. Recent literature suggests that individuals these areas may encounter health disparities, potentially leading to higher mortality from colorectal cancer (CRC) when compared their urban counterparts. The PREEMPT CRC is a prospective, multicenter clinical study designed validate an investigational blood test (MyTectCRC) intended provide convenient and accessible option for screening. included decentralized...
e13530 Background: Colorectal cancer (CRC) is the second deadliest in U.S. and while rates vary among racial/ethnic groups, Black community disproportionately impacted with highest incidence mortality rates. Notably, CRC have also been rising younger individuals aged 45 to 49. Recruitment of diverse underrepresented such as populations described above, increasingly important enhance generalizability real world performance clinical studies. Freenome developing a blood-based test (MyTectCRC)...
e23025 Background: Diversity in clinical studies is crucial aligning the study population with intended patient demographic. Freenome developing a blood based test (MyTectCRC) to offer convenient and accessible option for colorectal cancer (CRC) screening. Its validation supported by PREEMPT CRC study, prospective, multi-center observational study. was able achieve diverse representing various ethnic, racial, geographical backgrounds that reflect United States population. This analysis...
e15526 Background: Recent research suggested that current blood tests are not cost-effective for colorectal cancer (CRC) screening in patients declining other options, i.e., compared to those patients.(1) The findings were from a new decision-analytic model evaluating multi-cancer detection (MCD) test. Relative this MCD test, emerging “targeted” CRC have higher sensitivity precursors and lower specificity subjects without any adenomas or CRC. We examine the cost-effectiveness of these tests....