A5056710224- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Microscopic Colitis
- Child and Adolescent Health
- Diet and metabolism studies
- Obesity and Health Practices
- Liver Disease Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Streptococcal Infections and Treatments
- Otolaryngology and Infectious Diseases
- Urinary Tract Infections Management
- Reproductive tract infections research
- COVID-19 Clinical Research Studies
- Thyroid Disorders and Treatments
- Adolescent and Pediatric Healthcare
- COVID-19 and Mental Health
- Neuroendocrine Tumor Research Advances
- Neuroscience of respiration and sleep
- Health and Medical Studies
- Child Nutrition and Feeding Issues
- Celiac Disease Research and Management
- Genetic Neurodegenerative Diseases
- Inflammatory Bowel Disease
- Gastroesophageal reflux and treatments
RWTH Aachen University
2018-2025
Universitätsklinikum Aachen
2021-2024
Westfälische Hochschule
2021
OBJECTIVES With this study, our aim was to quantify the relative risk (RR) of diabetic ketoacidosis at diagnosis type 1 diabetes during year 2020 and assess whether it associated with regional incidence coronavirus disease 2019 (COVID-19) cases deaths. METHODS Multicenter cohort study based on data from German Diabetes Prospective Follow-up Registry. The monthly RR for in estimated observed expected rates 3238 children new-onset diabetes. Expected were derived 2000 by using a multivariable...
Objective To assess if metabolic control worsened during the SARS-CoV2 lockdown in spring 2020 youth with type 1 diabetes (T1D) Germany. Methods Data from 19,729 pediatric T1D patients prospective follow-up (DPV) registry were available. sets four time-periods between January and June 30, 2020, compared data whole year 2019 same patient; differences adjusted for seasonality, increasing age, longer duration. HbA1c values laboratory measurements estimates derived continuous glucose monitoring...
Background: In paediatric osteoarticular infections, microorganism detection is unsuccessful in up to 55% of cases, which not satisfactory for targeted antibiotic therapy. particular, anaerobic fusobacteria may be underdiagnosed owing a lack knowledge about their properties. Methods: Based on three our own cases and systematic literature review regarding fusobacterial we extracted characteristic variables synthesised them terms frequencies mean comparisons. We followed the CARE PRISMA...
Abstract Objectives Recent studies have suggested a link between type 1 diabetes mellitus (T1D) and metabolic dysfunction associated steatotic liver disease (MASLD) in children adolescent, but longitudinal evidence is lacking. This study aimed to investigate the potential association poorly controlled T1D elevated alanine aminotransferase (ALT), serving as proxy for MASLD adolescents over time. Methods The included 32,325 aged 2−17 years with from Germany, Austria, Switzerland who had...
Objectives To study celiac-specific antibody status over 3 years in patients with type 1 diabetes and biopsy-proven celiac disease (T1D + CD). Furthermore, to determine clinical differences after diagnosis between reaching constant antibody-negativity (Ab-neg) staying antibody-positive (Ab-pos). Methods A total of 608 pediatric T1D CD from the multicenter DPV registry were studied longitudinally regarding their specific antibody-status. Differences Ab-neg (n = 218) Ab-pos 158) biopsy...
Objectives CD4+ memory T cells facilitate long-termed adaptive immune responses while NK are predominately rapid effector with significant functions for both intestinal homeostasis and inflammation. We wanted to study populations in health pediatric inflammatory bowel disease (IBD) correlate them activity medication. Methods performed flow cytometric analyses of peripheral blood CD4 + CD45RO+ CD3-CD16 CD56+ 30 patients IBD 31 age-matched controls correlated percentages subsets (PUCAI/PCDAI)...
Abstract Background To evaluate the association between thyroid autoimmunity and psychiatric disorders (depression, anxiety, eating disorder, schizophrenia or attention‐deficit/hyperactivity disorder) among adolescents young adults with type 1 diabetes (11‐25 years). Methods We compared 9368 patients (3789 of them treated levothyroxine) 62 438 without any disease from a multicentre patient follow‐up registry (DPV) in terms disorders. Thyroid was defined as documented diagnosis Hashimoto...
This study intended to explore the existence of a temporal association changes sleep stage and gastroesophageal reflux (GER) in infants.Documentation GER was conducted via use synchronized polygraphic recording combined with impedance-pH-metry 15 infants. The total recording-time (Rt) divided into GER-"window-time" (five seconds before after onset episode), "remaining time", "GER-free analyzed for stage.a 462 episodes were identified during Rt (151.1 h) all During 1.3 h window-time; 61...
Zusammenfassung Ziele Verbesserung von krankheitsspezifischem Wissen bei pädiatrischen Patienten mit chronisch-entzündlichen Darmerkrankungen (CED) mittels digitaler App und individualisiertem Teaching Arzt zu Patient. Methoden Wir entwickelten die KARLOTTA-App (Kids + Adolescents Research Learning On Tablet Aachen) für Android-Software Geschicklichkeitsspiel CED-Fragenkatalog visuellem Feedback High-Scores. Randomisierte kontrollierte Studie als Pilotprojekt 30 CED-Patienten, 10–18 Jahre....
During the first phase of COVID-19 pandemic, DPV (the German diabetes registry database) study group asked whether or not lockdown had affected incidence pediatric T1D in Germany (1). More than 210 centers contributed their data on patients with an onset at ages between 6 months and <18 years diagnosed 13 March May each year 2011 2020. The latter period corresponds to increased from 16.4 [95% CI 14.7–18.2] 22.2 [20.3–24.2] 2019 (P=0.04). 2020, based 532 cases among 13.6 million subjects...
Fragestellung: Bariatrische Chirurgie (BC) ist eine etablierte Therapieoption für Menschen mit Typ-2-Diabetes (T2D) einem BMI ≥ 35 kg/m2 und zeigt im Vergleich zur konservativen Therapie häufiger Remission des T2D, sowie nachhaltigen Gewichtsverlust. Auch bei Typ-1-Diabetes (T1D) nimmt die Prävalenz von Adipositas Parametern metabolischen Syndroms zu. Die Rolle der BC T1D jedoch unzureichend charakterisiert. Ziel dieser Analyse es, derzeitige Praxis Auswirkungen verschiedener bariatrischer...
Data on the prevalence, clinical features and risk factors associated with paediatric diabetic neuropathy (DN) are scarce.We retrospectively analysed data from DPV registry, including patients under 20 years of age, treated for type 1 diabetes mellitus (T1D) between 2005 2021. Patients non-diabetic were excluded. came centres in Austria, Germany, Luxembourg Switzerland.1,121 84,390 included had been diagnosed DN. Univariate analysis showed DN to be older predominantly female, a longer...
Zielsetzung Die Patientenversorgung wurde durch die Pandemie der Coronaviruserkrankung 2019 (COVID-19) beeinträchtigt. Wir untersuchten den Zusammenhang zwischen dem regionalen Schweregrad und Risiko einer diabetischen Ketoazidose bei Kindern mit neu aufgetretenem Typ-1-Diabetes.
Zusammenfassung Übergewicht, Adipositas und die assoziierten Folgeerkrankungen sind ein ernstzunehmendes Problem für Gesundheit von Kindern Jugendlichen. Bereits jetzt ist jedes 6. Kind in Deutschland übergewichtig oder adipös. Die Folgen häufig Leid Betroffenen ihre Familien Belastungen das Gesundheitssystem durch nachfolgende Krankheiten wie Bluthochdruck, metabolisches Syndrom auch mit Fettlebererkrankung Typ-2-Diabetes. Auf diese Entwicklung wirkte Corona-Pandemie unter mehreren Aspekten...
ZUSAMMENFASSUNG Übergewicht, Adipositas und die assoziierten Folgeerkrankungen sind ein ernstzunehmendes Problem für Gesundheit von Kindern Jugendlichen. Bereits jetzt ist jedes 6. Kind in Deutschland übergewichtig oder adipös. Die Folgen häufig Leid Betroffenen ihre Familien Belastungen das Gesundheitssystem durch nachfolgende Krankheiten wie Bluthochdruck, metabolisches Syndrom auch mit Fettlebererkrankung Typ-2-Diabetes. Auf diese Entwicklung wirkte Corona-Pandemie unter mehreren Aspekten...