A5006566586- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Management of metastatic bone disease
- Bone and Joint Diseases
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Advanced MRI Techniques and Applications
- Brain Metastases and Treatment
- Adrenal and Paraganglionic Tumors
- Radiomics and Machine Learning in Medical Imaging
- Systemic Sclerosis and Related Diseases
- Vascular Procedures and Complications
- Peripheral Artery Disease Management
- Pituitary Gland Disorders and Treatments
- Hematological disorders and diagnostics
- Spine and Intervertebral Disc Pathology
- Neuroblastoma Research and Treatments
- Pulmonary Hypertension Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Cardiac Imaging and Diagnostics
- AI in cancer detection
- Neurofibromatosis and Schwannoma Cases
- Connective tissue disorders research
Memorial Sloan Kettering Cancer Center
2015-2024
Cornell University
2015-2022
University of Richmond
2016
Kettering University
2015
Hartford Hospital
2011
Hartford Financial Services (United States)
2011
Virginia Commonwealth University Medical Center
1980-1988
University of Michigan
1980
Uniformed Services University of the Health Sciences
1980
The majority of WHO grades II and III gliomas harbor a missense mutation in the metabolic gene isocitrate dehydrogenase (IDH) accumulate metabolite R-2-hydroxyglutarate (R-2HG). Prior studies showed that this can be detected vivo using proton magnetic-resonance spectroscopy (MRS), but sensitivity methodology its clinical implications are unknown.We developed an MR imaging protocol to integrate 2HG-MRS into routine glioma examined performance 89 consecutive patients.Detection...
Abstract Pituitary neuroendocrine tumors (PitNETs) exhibiting aggressive, treatment-refractory behavior are the rare subset that progress after surgery, conventional medical therapies, and an initial course of radiation characterized by unrelenting growth and/or metastatic dissemination. Two groups patients with PitNETs were sequenced: a prospective group ( n = 66) who consented to sequencing prior surgery retrospective 26) comprised aggressive/higher risk PitNETs. A higher mutational burden...
Use of isosulfan blue for identification lymphatic vessels: experimental and clinical evaluationJI Hirsch, J Tisnado, Cho, SR MC BeachleyAudio Available | Share
Abstract Brain metastases originating from different primary sites overlap in appearance and are difficult to differentiate with conventional MRI . Dynamic contrast‐enhanced ( DCE )‐ can assess tumor microvasculature has demonstrated utility characterizing brain tumors. Our aim was evaluate the performance of plasma volume V p) transfer coefficient K trans ) derived ‐ distinguishing between melanoma nonsmall cell lung cancer NSCLC metastases. Forty‐seven 23 were retrospectively assessed...
Background Dynamic contrast agent-enhanced (DCE) perfusion MRI may help differentiate between nonneoplastic and malignant lesions in the spine. Purpose To investigate correlation fractional plasma volume (Vp), a parameter derived from DCE MRI, histopathologic diagnosis for spinal lesions. Materials Methods In this retrospective study, patients who underwent lesion biopsy May 2015 2018 were included. Inclusion criteria short time interval (<30 days) biopsy, performed before at same spine...
Background Artificial intelligence (AI) applications for cancer imaging conceptually begin with automated tumor detection, which can provide the foundation downstream AI tasks. However, supervised training requires many image annotations, and performing dedicated post hoc labeling is burdensome costly. Purpose To investigate whether clinically generated annotations be data mined from picture archiving communication system (PACS), automatically curated, used semisupervised of a brain MRI...
Bleeding cytomegalovirus ulcers of the colon: barium enema nad angiographyCho, SR, J Tisnado, CI Liu, MC Beachley, Shaw, BE Kipreos and V SchneiderAudio Available | Share
OBJECTIVE Accurately determining diffuse intrinsic pontine glioma (DIPG) tumor volume is clinically important. The aims of the current study were to 1) measure DIPG volumes using methods that require different degrees subjective judgment; and 2) evaluate interobserver agreement measurements made these methods. METHODS Eight patients from a Phase I clinical trial testing convection-enhanced delivery (CED) therapeutic antibody included in study. Pre-CED, post-radiation therapy axial...
Weismann-Netter-Stuhl syndrome: toxopachyosteose diaphysaire tibio-peroniereMA Amendola, AC Brower and J TisnadoAudio Available | Share
Pulmonary embolism is an uncommon cause of a massive unilateral lung scan perfusion defect; other causes may mimic PE clinically. Angiography may, therefore, be essential for accurate diagnosis.
Dynamic contrast-enhanced MRI (DCE) is an emerging modality in the study of vertebral body malignancies. DCE-MRI analysis relies on a pharmacokinetic model, which assumes that contrast uptake simultaneous feeding arteries and tissues interest. While true highly vascularized brain, perfusion spine delayed. This delay reaching lesions can affect analyses, leading to misdiagnosis for presence active malignancy bone marrow. To overcome limitation delayed arrival lesions, we shifted arterial...
This extensive study of thoracic sarcoidosis calls attention to a number unusual manifestations the disease including airway compression, venous obstruction and direct pericardial myocardial involvement.
Musculoskeletal complaints are ubiquitous in healthcare, with orthopedic infection suspected a subset of cases. Plain radiographic evaluation is vital tool for first-line this setting. Important findings, including soft tissue and osseous abnormalities, can aid timely accurate diagnosis. Even nondiagnostic radiographs prove useful, illustrating the anatomy that will likely not be easily defined on magnetic resonance imaging or nuclear medicine studies. Our goal to review common findings seen...
Abstract The metabolic genes isocitrate dehydrogenase 1 (IDH1) or IDH2 are mutated in 70-80% of WHO grade II and III glioma. mutant IDH enzyme gains a new function producing D-2-hydroxyglutarate (2-HG). 2-HG is small molecule that accumulates gliomas as high 5 to 35 mM considered the principal effector mutation cancers. Proton magnetic resonance spectroscopy (MRS) an approved method brain tumors identify quantify metabolites within lesions by using signals emitted proton nuclei (1H). has...
Intraoperative identification of chylous fistulas using iso-sulphan blue dyePJ Rubis, J Tisnado, JI Hirsch and CapehartAudio Available | Share
<h3>BACKGROUND AND PURPOSE:</h3> Current imaging techniques have difficulty differentiating treatment success and failure in spinal metastases undergoing radiation therapy. This study investigated the correlation between changes dynamic contrast-enhanced MR perfusion parameters clinical outcomes following therapy for metastases. We hypothesized that will outperform traditional size measurements discriminating failure. <h3>MATERIALS METHODS:</h3> retrospective included 49 patients (mean age,...