A5100432098- Herpesvirus Infections and Treatments
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- interferon and immune responses
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Microbial infections and disease research
- Hepatitis Viruses Studies and Epidemiology
- Preterm Birth and Chorioamnionitis
- Plant Virus Research Studies
- Toxoplasma gondii Research Studies
- Virology and Viral Diseases
- Neonatal and Maternal Infections
- Aquaculture disease management and microbiota
- Bacteriophages and microbial interactions
- Vector-borne infectious diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Plant biochemistry and biosynthesis
- Bacterial Infections and Vaccines
- Abdominal vascular conditions and treatments
- Stroke Rehabilitation and Recovery
- IgG4-Related and Inflammatory Diseases
- Dengue and Mosquito Control Research
Henan Agricultural University
2012-2025
Fujian Medical University
2023
Fuzhou Maternity and Child Health Care Hospital
2022-2023
Affiliated Hospital of North Sichuan Medical College
2022
Chinese University of Hong Kong
2016
University of Saskatchewan
2015
Peking Union Medical College Hospital
2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2015
Wuhan University
2011
Renmin Hospital of Wuhan University
2011
Since May 2015, severe outbreaks of hepatitis-hydropericardium syndrome (HHS) associated with infections fowl aviadenovirus (FAdV) have emerged in broiler chickens several Chinese provinces. To identify the genotype and gain a better understanding genetic properties FAdV strains responsible for recent HHS China, complete genome sequences five isolates from provinces were determined. The results demonstrated that novel 4 (FAdV-4) was epidemic China. investigate molecular characteristics these...
Pseudorabies (PR) is a significant disease that adversely affects the healthy growth of pig industry in China. However, data on molecular epidemiology and genetic characterization PRV sparse. This study examined epidemic trends variation characteristics PR virus (PRV) Henan Province Six hundred eighty-eight clinically infected tissue samples were collected from 18 cities January 2021 to March 2023 tested for PRV. The was isolated positive identified by polymerase chain reaction...
Interferon-stimulated gene 15 (ISG15) is strongly upregulated during viral infections and exerts pro-viral or antiviral actions. While many viruses combat host defenses by limiting ISG expression, PRV infection notably increases expression of ISG15. However, studies on the strategies to regulate ISG15-mediated responses are limited. Here, we demonstrate that PRV-induced free ISG15 conjugated proteins accumulation require expression. Conjugation inhibition assays showed imposes its effects...
Abstract Background Streptococcus agalactiae or group B (GBS) is a leading infectious cause of neonatal morbidity and mortality. It essential to establish robust method for the rapid ultra-sensitive detection GBS in pregnant women with premature rupture membrane (PROM). Methods This study developed CRISPR-GBS assay that combined advantages recombinase polymerase amplification (RPA) CRISPR/Cas12a system detection. The clinical performance was assessed using vaginal cervical swabs were...
Background Although self-esteem is related to problematic drinking, the mechanisms by which it affects drinking remain unclear. The purpose of this study was determine whether coping mediate relationship between and among Chinese men women with alcohol use disorders recommend appropriate interventions for problems. Methods A cross-sectional survey conducted in Harbin, Heilongjiang Province, China. sample 5,689 community residents screened, 517 male 172 female drinkers were chosen participate...
Re-emerging pseudorabies (PR) caused by virus (PRV) variant has been prevailing among immunized herds in China since 2011, indicating that commercially available PR vaccine strains couldn't provide complete protection against novel, epidemic PRV variant. Before this study, a gE/TK-gene-deleted (PRV ΔgE/TK) was constructed from QYY2012 through homologous recombination and Cre/LoxP system. Here, ΔgE/TK/US3 strain generated deleting US3 gene based on ΔgE/TK using the same method. The growth...
Chicken infectious anemia (CIA) is an immunosuppressive disease caused by the chicken virus (CIAV) resulting in heavy economic losses once outbreak established. This study conducted a systematic analysis of epidemiology and pathology CIA Henan province, China. A total 437 clinical tissue samples 120 poultry disease-related live attenuated vaccines were collected during 2017-2020; which 45 positive for CIAV nucleic acid, with rate 8.08%. Our results showed that genome sequence similarity...
Hepatitis E virus (HEV) is a small nonenveloped single‐stranded positive‐sense RNA and one of the major causes for acute hepatitis worldwide. CXCL‐8 multifunctional proinflammatory chemokine. It was reported recently that HEV infection significantly upregulates gene expression. In this study, we investigated mechanism HEV‐induced transcriptional activation. Using promoter reporters different lengths ranging from −1400 to −173, showed −173 has highest activity in presence genomic RNA,...
Viral-encoded microRNAs (miRNAs) have vital roles in the regulation of virus replications and host immune responses. The results previous studies indicated that miRNA clusters are involved replication virulence pseudorabies (PRV), which may potentially lead to escape or facilitation PRV replication. This study's research revealed prv-miR-LLT11a was differentially expressed during infection. present demonstrated could significantly inhibit It further determined SLA-1 target gene...
Onychomadesis occurs when the nail plate separates from matrix and bed, eventually leading to shedding of nail. This condition has been attributed viral infections, autoimmune disorders, drug side effects, physical trauma. A subset patients a recurrent form onychomadesis without clear trigger; this phenomenon is not well characterized in literature.We present case series pediatric adult with toenail order better characterize disorder explore possible etiologies, risk factors, treatments.For...
A strain of encephalomyocarditis virus, HNXX13, was isolated from an aardvark in central China. The complete genome sequenced and analyzed, phylogenetic analysis suggests that HNXX13 belongs to virus group 1.
Pseudorabies virus (PRV) can establish lifelong latent infection in peripheral nervous ganglion, and persistent infections blood lymphocytes. Establishing an the lymphocytes does not only enable PRV to escape host immune surveillance but pass through placental barrier, leading fetal death abortion. Due pathogenicity of PRV, it poses a huge challenge its prevention control. The escapes immunity downregulation swine leukocyte antigen class I (SLA I) molecules on infected cells. However, data...
Here we described brain lesion in young captive lions after exhibiting ataxia. The histopathological analyses of the showed typical encephalitis with glial cell proliferation, neuronal atrophy and necrosis, encephalomalacia. We used a variety identification methods, including next-generation sequencing, polymerase chain reaction (PCR), virus isolation, immunofluorescence staining (IFA), electron microscopy. Combined clinical manifestations infected cub, it determined that dead cub have...
To investigate the effectiveness difference between bone transport with a locking plate (BTLP) and conventional Ilizarov/Orthofix fixators in treatment of tibial defect.The clinical data 60 patients fractures who met selection criteria January 2016 September 2020 were retrospectively analyzed, treated BTLP (BTLP group, n=20), Ilizarov fixator (Ilizarov n=23), or Orthofix (Orthofix n=17) for transport. There was no significant gender, age, cause injury, time from injury to admission, length...
Introduction: In the past two decades, there has been 84% increase of stroke prevalence in China. Since transitional care facilities are lacking China, most survivors return home after discharged from acute hospital setting. Routine disease-oriented discharge planning does not match individual needs. Objective: To evaluate effectiveness a modified (HC) intervention to facilitate transition for home. Methods: Using quasi-experimental study design, 115-bed unit teaching China were recruited....