A5053581966- Neonatal and Maternal Infections
- Bacterial Infections and Vaccines
- Neonatal and fetal brain pathology
- Preterm Birth and Chorioamnionitis
- Streptococcal Infections and Treatments
- Genomic variations and chromosomal abnormalities
- Pneumonia and Respiratory Infections
- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Biomedical Ethics and Regulation
- Reproductive tract infections research
- RNA and protein synthesis mechanisms
- Chemical Synthesis and Analysis
- Chemical synthesis and pharmacological studies
- Polymer Synthesis and Characterization
- Machine Learning in Bioinformatics
- Genetic Syndromes and Imprinting
- Prenatal Screening and Diagnostics
Fujian Medical University
2020-2023
Fuzhou Maternity and Child Health Care Hospital
2023
Fujian Women and Children Hospital
2022-2023
Abstract Background Streptococcus agalactiae or group B (GBS) is a leading infectious cause of neonatal morbidity and mortality. It essential to establish robust method for the rapid ultra-sensitive detection GBS in pregnant women with premature rupture membrane (PROM). Methods This study developed CRISPR-GBS assay that combined advantages recombinase polymerase amplification (RPA) CRISPR/Cas12a system detection. The clinical performance was assessed using vaginal cervical swabs were...
This study investigated the molecular epidemiology of Group B Streptococcus (GBS) in pregnant women with premature rupture membranes (PROM) Fuzhou region China as a source clinical reference.GBS isolates were obtained from PROM. All genotyped, serotyped, and tested for drug-resistance virulence genes using PCR DNA sequencing. Antibiotic susceptibility testing was performed Vitek® 2 automated system.Among 140 GBS isolates, seventeen sequence types (STs) identified, which ST19 (20.0%) most...
17p13.3 microdeletions or microduplications (collectively known as copy number variants CNVs) have been described in individuals with neurodevelopmental disorders. However, CNVs were rarely reported fetuses. This study aims to investigate the clinical significance of varied sizes and gene content prenatal postnatal samples. Eight cases out 8806 samples that had subjected single nucleotide polymorphism array analysis retrospectively analyzed, along karyotyping, features, follow-up. consisted...
One of the most important function G protein-coupled receptors family C subtype 6A (GPRC6A) recognizes and responds to L-amino acids as its principal physiological ligand.In this study, homology modeling, molecular docking dynamics simulation were performed explore structural features binding mechanism on SsGPRC6A Sus scrofa, construct model containing domain ligands for searching functional special polypeptide recognize respectively.The was constructed using crystal structure extracellular...
Abstract Background Streptococcus agalactiae or group B (GBS) is a leading infectious cause of neonatal morbidity and mortality. It essential to establish robust method for the rapid ultra-sensitive detection GBS in pregnant women with premature rupture membrane (PROM). Methods This study developed CRISPR-GBS assay that combined advantages recombinase polymerase amplification (RPA) CRISPR/Cas12a system detection. The clinical performance was assessed using vaginal cervical swabs were...
Abstract Background Group B Streptococcus (GBS) colonization in late pregnancy is associated with premature rupture of membranes (PROM) and preterm delivery, may lead to ascending infection neonatal early-onset disease. This study aims determine the prevalence, antimicrobial susceptibility, serotypes, molecular characterization GBS strains Fuzhou region China. Methods A total 140 isolates were obtained from pregnant women PROM. All genotyped, serotyped tested for drug-resistance virulence...