A5057194088- Dental Erosion and Treatment
- MicroRNA in disease regulation
- Oral microbiology and periodontitis research
- Dental Health and Care Utilization
- Extracellular vesicles in disease
- Genetics, Aging, and Longevity in Model Organisms
- Reproductive System and Pregnancy
- Oral and Craniofacial Lesions
- Eosinophilic Esophagitis
- RNA Interference and Gene Delivery
- Fibroblast Growth Factor Research
- IL-33, ST2, and ILC Pathways
- Esophageal Cancer Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Gastroesophageal reflux and treatments
- Metabolism, Diabetes, and Cancer
- Light effects on plants
- Temporomandibular Joint Disorders
- Bone and Dental Protein Studies
- Bone and Joint Diseases
- CRISPR and Genetic Engineering
Second Affiliated Hospital of Zhejiang University
2024
Shanghai Jiao Tong University
2013-2024
Ruijin Hospital
2023-2024
Shanghai Sixth People's Hospital
2019
Shanghai Ninth People's Hospital
2001-2016
Norwegian University of Science and Technology
2004
Osteoarthritis (OA) is the most common degenerative joint disease in world. Gene therapy based on delivering microRNAs (miRNAs) into cells has potential for treatment of OA. However, effects miRNAs are limited by poor cellular uptake and stability. Here, we first identify a type microRNA-224-5p (miR-224-5p) from clinical samples patients with OA that can protect articular cartilage degeneration further synthesize urchin-like ceria nanoparticles (NPs) load miR-224-5p enhanced gene Compared...
Background: Most previous studies of reflux symptom prevalence are small sample size. No reliable data concerning age- and sex-stratified available. Methods: Among 65,363 adult participants in a public health survey Nord-Trondelag, Norway, 58,596 (90%) responded occurrence severity heartburn or regurgitation during the past 12 months. The minor, severe any symptoms was calculated, including stratification for age sex. In order to examine whether relative risk between sexes, different groups,...
Objectives To describe the characteristics of patients who visited halitosis clinic and to investigate factors that may associate with halitosis. Materials Methods Nine hundred eleven patients, for consultations, underwent organoleptic tests volatile sulfur compound ( VSC ) measurements a portable sulfide monitor. The oral health including dental caries, hygiene, gingival inflammation status, was assessed. Questionnaires were used obtain information on demographics, hygiene practices,...
To compare differences in oral health-related quality of life (OHRQoL) between halitosis and non-halitosis patients to explore relationships OHRQoL.Patients who visited the clinic at Ninth People's Hospital were diagnosed with included group. The control group consisted without halitosis. All participants assessed for (volatile sulphur compound measurements a portable sulphide monitor, Oral Chroma organoleptic tests), underwent clinical examination (dental caries status periodontal...
Abstract A fundamental understanding of inflammation and tissue healing suggests that the precise regulation inflammatory phase, both in terms location timing, is crucial for bone regeneration. However, achieving activation early without causing chronic while facilitating quick regression to promote regeneration continues pose challenges. This study reveals black phosphorus (BP) accelerates by building an osteogenic immunological microenvironment. BP amplifies acute pro‐inflammatory response...
Exosomes are considered important "messengers" between cells and their cargo, some of the miRNAs composing cargo may be involved in oncogenic activity. Exosomal miRNA423-5p (Ex-miRNA423-5p) is upregulated gastric cancer associated with its poor prognosis. However, role exosome-derived papillary thyroid (PTC) still unclear needs further study. In our work, we found that level Ex-miRNA423-5p was significantly increased serum PTC patients compared normal healthy people, vitro, demonstrated...
Abstract Wounding initiates intricate responses crucial for tissue repair and regeneration. Yet, the gene regulatory networks governing wound healing remain poorly understood. Here, employing single-worm RNA sequencing (swRNA-seq) across 12 time-points, we delineated a three-stage process in C. elegans : response, repair, remodeling. Integrating diverse datasets, constructed dynamic network comprising 241 transcription regulators their inferred targets. We identified potentially seven...
Abstract The hypoxia-inducible factor-1α (HIF-1α) pathway coordinates skeletal bone homeostasis and endocrine functions. Activation of the HIF-1α increases glucose uptake by osteoblasts, which reduces blood levels. However, it is unclear whether activating in osteoblasts can help normalize metabolism under diabetic conditions through its function. In addition to increasing mass reducing levels, specifically knocking out Von Hippel‒Lindau ( Vhl ) partially alleviated symptoms streptozotocin...