A5101202942- Aquatic Ecosystems and Phytoplankton Dynamics
- Marine and coastal ecosystems
- Protein Degradation and Inhibitors
- Fish Ecology and Management Studies
- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Microbial Community Ecology and Physiology
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Marine and fisheries research
- Fish Biology and Ecology Studies
- Freshwater macroinvertebrate diversity and ecology
- Viral Infectious Diseases and Gene Expression in Insects
- Gene Regulatory Network Analysis
- Reproductive biology and impacts on aquatic species
- Bioinformatics and Genomic Networks
- Coastal wetland ecosystem dynamics
- Regional Development and Environment
- Genetics, Aging, and Longevity in Model Organisms
- CRISPR and Genetic Engineering
- Light effects on plants
Yangtze University
2019-2024
Zhejiang University-University of Edinburgh Institute
2024
Key Laboratory of Guangdong Province
2024
Karyopharm Therapeutics (United States)
2024
<div>Abstract<p>Several therapeutic agents have been approved for treating multiple myeloma, a cancer of bone marrow–resident plasma cells. Predictive biomarkers drug response could help guide clinical strategies to optimize outcomes. In this study, we present an integrated functional genomic analysis tumor samples from patients myeloma that were assessed their <i>ex vivo</i> sensitivity 37 drugs, variables, cytogenetics, mutational profiles, and transcriptomes. This...
<p>This file contains four supplementary tables S1 - S4 and eight figures S8.</p>
Abstract Mammalian animal model species for preclinical drug testing share a large number of genes with similar names and/or protein primary structures, but gene expression patterns in different tissues and response to drugs have not been previously systematically characterized. Here, we experimentally measure the responses (reactomes) each mouse rat genomes 10 organs 3 drugs. Surprisingly, observe that reactomes across generally do correlate structural similarity. Thus, propose an...
The impact of global climate change has led to an increase in extreme rainfall events, causing fluctuations terrigenic inputs that significantly affect aquatic communities. Lake Changhu, the third-largest freshwater lake Hubei Province, plays a crucial role as reservoir germplasm resources middle reaches Yangtze River. In recent years, experienced series events. response 42-day mesocosm experiment was conducted understand effect on various aspects phytoplankton such species composition,...
Abstract Wounding initiates intricate responses crucial for tissue repair and regeneration. Yet, the gene regulatory networks governing wound healing remain poorly understood. Here, employing single-worm RNA sequencing (swRNA-seq) across 12 time-points, we delineated a three-stage process in C. elegans : response, repair, remodeling. Integrating diverse datasets, constructed dynamic network comprising 241 transcription regulators their inferred targets. We identified potentially seven...
为探究长江中下游富营养化浅水湖泊的浮游植物初级生产力季节性演替特征及其驱动因子，本研究于2020年4月（春）、8月（夏）、10月（秋）及2021年1月（冬）对湖北长湖浮游植物进行采样调查，同时运用黑白瓶测氧法及VGPM模型估算法分别估算了其浮游植物生产力水平，并探究驱动初级生产力季节性变化的主要环境因子。结果显示，4个季节共鉴定出浮游植物194种，其中绿藻门（95种，49%）和硅藻门（40种，21%）居绝对优势地位；黑白瓶法测得浮游植物水柱总生产力（P<sub>t</sub>）季节变化为：夏季（（1841.24±345.93） mg C/（m<sup>2</sup>·d））>秋季（（1324.14±208.34） C/（m<sup>2</sup>·d））>春季（（847.50±247.72） C/（m<sup>2</sup>·d））>冬季（（711.43±133.52） C/（m<sup>2</sup>·d）），其中M2站位在夏季采样时（2424.66...
于2012年4月至2013年1月对长湖浮游植物群落结构特征进行调查分析,使用Levins生态位宽度公式和Levins重叠公式测定长湖浮游植物优势种的生态位指数,分析浮游植物站点分布和环境因子的变化与生态位间的关系.结果显示:整个区域以蓝藻门和绿藻门的种类为主,优势种种类和密度随季节变化,表现出1~2个种类成为主要优势种,在丰度、优势度和生态位宽度上远大于其他优势种的特征.依据优势度指数和生态位宽度将优势种分为3类;小球藻(Chlorella vulgaris)和扭曲小环藻(Cyclotella comta)作为4个季节优势种,占据更多的资源位点,有更大的生态位宽度,在竞争中处于优势.蓝藻门的两栖颤藻(Oscillatoria...
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Phosphorus (P) plays a vital role in fish life and its application aquatic feed deserves thoroughly study. To evaluate the effects of dietary P on growth performance, serum biochemical parameters intestinal microbiota juvenile hybrid A. baerii♀ × schrenckii♂, five diets containing 3.7, 6.5, 9.6, 12.2 14.8 g/kg available phosphorus (AP) were assigned to at initial weight 10.06 ± 0.39 g for 8 weeks. The results showed that gain (WG) sturgeon was improved significantly with AP level up 9.6...
Abstract Objective We sought to assess the efficacy of feeding tocotrienol, a member vitamin E family, as it impacts physiological functions in fingerling fish. Methods Fingerling Largemouth Bass Micropterus nigricans with an initial mean body weight (±SD) 0.98 ± 0.09 g were fed five diets containing tocotrienol at 0, 10, 20, 30, and 40 mg/kg (T0, T10, T20, T30, T40 diets, respectively) for 42 days. After experiment, fish challenged ranavirus (LMBV) monitored 48 h. Result Findings indicated...
Abstract Several therapeutic agents have been approved for treating multiple myeloma (MM), a cancer of bone marrow resident plasma cells. Predictive biomarkers drug response could help guide clinical strategies to optimize outcomes. Here, we present an integrated functional genomic analysis tumor samples from MM patients that were assessed their ex vivo sensitivity 37 drugs, variables, cytogenetics, mutational profiles, and transcriptomes. This revealed transcriptomic topology generates...