A5104666948- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- SARS-CoV-2 and COVID-19 Research
- Reproductive Biology and Fertility
- Folate and B Vitamins Research
- Pregnancy and Medication Impact
- Glaucoma and retinal disorders
- Pancreatic function and diabetes
- Organometallic Compounds Synthesis and Characterization
- Head and Neck Surgical Oncology
- Reproductive System and Pregnancy
- Airway Management and Intubation Techniques
- Pneumonia and Respiratory Infections
- RNA modifications and cancer
- Drug Transport and Resistance Mechanisms
- Cancer Immunotherapy and Biomarkers
- Hepatitis B Virus Studies
- Retinopathy of Prematurity Studies
- Bacterial Infections and Vaccines
- Metal complexes synthesis and properties
- SARS-CoV-2 detection and testing
- Protease and Inhibitor Mechanisms
- Genetic factors in colorectal cancer
- Dermatological and COVID-19 studies
Integrated Chinese Medicine (China)
2024-2025
Fourth Affiliated Hospital of Anhui Medical University
2020-2023
Anhui Medical University
2012-2023
Zhejiang University
2012-2023
Hangzhou First People's Hospital
2023
Anhui Provincial Children's Hospital
2022-2023
Children's Hospital of Fudan University
2022-2023
Second Affiliated Hospital of Zhejiang University
2021
University of Science and Technology of China
2020
Nanjing Drum Tower Hospital
2016-2019
Abstract To conquer the worldwide outbreak of COVID-19 virus, a large number studies have been carried out on infection, transmission and treatment. However, few conducted from perspectives circRNA lncRNA, which are known to be involved in regulating many life activities, such as immune tolerance escapes, hence may provide invaluable information emerging infection recurrence. Moreover, exosomes has reported play an important role recurrence, thus interact with expression lncRNA. In this...
Autophagy is a lysosomal degradation process which key for the regulation of turnover long-lived or damaged proteins and organelles promotes cell survival during nutrient deprivation other microenvironmental stresses. Current evidence supports hypothesis that autophagy suppresses tumorigenesis, particularly early stages tumor initiation. However, in established tumors, under stressful conditions cancer progression response to chemotherapy; however, mechanism by influences metastasis remains...
The spindle assembly checkpoint (SAC) has been established as an important mechanism of driving aneuploidy, which occurs at a high frequency in the colorectal tumorigenesis. Two components SAC are MAD1L1 and MAD2L1, function together interactive manner to initiate signal. We hypothesize that genetic variants binding domains MAD2L1 may modulate protein structures eventually contribute CRC susceptibility. A case-control study including 710 cases 735 controls was performed examine Arg558His...
Acute kidney injury (AKI) is a life-threatening condition with limited early biomarkers. Mitochondrial dysfunction central to AKI pathophysiology, yet its potential for predicting remains underexplored. Gene expression data from three publicly available datasets (GSE30718, GSE61739, and GSE139061) were analyzed identify differentially expressed genes (DEGs). A set of 11 mitochondrial-related was selected used construct mitochondrial risk score (MRS) model via Lasso elastic net regression....
Abstract Matrix metalloproteinase‐2 (MMP‐2) and ‐9 (MMP‐9) play an important role in cancer initiation, invasion, metastasis. The aim of this study was to investigate whether common genetic variants these two key MMPs are associated with the development progression colorectal a Chinese population. We detected MMP‐2‐790T/G, ‐955A/C, ‐1575G/A, MMP‐9‐1562 C/T polymorphisms 126 patients matched normal controls by PCR‐denaturing high‐performance liquid chromatography (DHPLC) or PCR‐restriction...
Abstract Background Reverse transcription‐polymerase chain reaction (RT‐PCR) is an extremely common clinical method for detecting pathogens, particularly emerging infectious diseases such as the new coronavirus disease (COVID‐19). Currently, detection of RNA from novel SARS‐CoV‐2 gold standard establishing a COVID‐19 diagnosis. This study evaluates characteristic performance analytical system in laboratory. Methods A commercial RT‐PCR Kit used laboratory assessed based on ISO 15189...
Conformal microcapsules encapsulating microcarrier-L02 cell complexes for treatment of acetaminophen-induced liver injury in rats.
Background Pancreatic cancer (PC) is one of the most lethal malignant tumors with no valid biomarkers for early diagnosis. We evaluated value PD-1, PD-L1, PD-L2, CD28, B7-1, and B7-H5 diagnosing PC. Methods measured serum soluble B7-H5, carbohydrate antigen (CA)19-9 levels in 87 patients PC, 27 benign pancreatic disease, 20 healthy volunteers. diagnostic CA19-9, B7-H5. Results Patients PC had significantly higher Combined detection (CA19-9 + PD-L1 PD-L2 B7-H5) much sensitivity than single...
The management of cerebral abscesses caused by dark-pigmented Fonsecaea monophora in healthy individuals continues to be challenging due no consensus on the therapeutic regimen. Due absence an accurate identification method, species are often misidentified indistinct morphology features.An F. strain from immunocompetent host with abscess was collected and identified ITS rDNA molecular sequencing. sequences isolate were compared that other ten Chinese isolates obtained GenBank for difference...
Background: Hepatitis B surface antigen (HBsAg) and viral load are important clinical indicators for antiviral therapy. Few studies have evaluated sequence biomarkers predicting the risk of hepatocellular carcinoma (HCC) in stage, which show a low serological response (HBsAg < 100 IU/ml) high levels (HBV DNA > 2,000 IU/ml). This study aims to determine trend biological prevalence within pre-S/S regions special model inactive CHB infection. Methods: We used Sanger sequencing,...
To investigate the associations between demographic and clinical factors with rate of visual field mean derivation (MD) decline in retinitis pigmentosa (RP) patients.Correlations MDs acuity retinal pigmentation were analyzed 928 RP patients. MD decreasing 10y potential influences gender, age, family history on explored 201 patients.In patients, average -14.44±8.61 dB 0.79±0.35 respectively when was lower than -9.18 would be below 1.0 (20/20). The medium eyes or without -14.82 dB. In 123...
To investigate the effects of miR-137 on biological cell function nasopharyngeal carcinoma (NPC) cells. Totally, 31 pairs NPC tissues and para-cancer were collected. Meanwhile, human immortalized epithelial lines (NP69) (6-10B) cultured. The abilities proliferation, invasion migration detected by CCK-8 Transwell assay, respectively. relative protein mRNA expression level was Western blot quantitative real-time polymerase chain reaction (qRT-PCR) analysis. In experiment, found widely...
ObjectiveIn this study, we aimed to investigate whether age first had sexual intercourse (AFSI) and lifetime number of partners (LNSP) have a direct causal effect on cervical cancer by Mendelian randomization (MR) analysis.MethodsFour approaches were used for MR Analysis, including MR-Egger, weighted method, median, inverse variance (IVW). Pleiotropy RESidual Sum Outlier (MR-PRESSO) as well MR-Egger regression analysis conducted detect there was pleiotropy between IVs outcome, the outlier...
<b><i>Purpose:</i></b> As a small-molecule tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), apatinib has shown survival benefit in multiple solid tumors. This study aims to evaluate the efficacy and safety patients with metastatic, recurrent cervical cancer after failure radiotherapy first-line chemotherapy. <b><i>Methods:</i></b> A total 42 between June 2018 March 2019 were involved this study. All orally...