A5089765551- Cutaneous Melanoma Detection and Management
- Skin Protection and Aging
- Nonmelanoma Skin Cancer Studies
- Photodynamic Therapy Research Studies
- Infectious Diseases and Mycology
- Single-cell and spatial transcriptomics
- Herpesvirus Infections and Treatments
- Virology and Viral Diseases
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Nail Diseases and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Melanoma and MAPK Pathways
- melanin and skin pigmentation
- Radiomics and Machine Learning in Medical Imaging
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Autoimmune Bullous Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- Fungal Infections and Studies
- Hungarian Social, Economic and Educational Studies
- Allergic Rhinitis and Sensitization
- Cutaneous lymphoproliferative disorders research
- Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
University of Debrecen
2015-2024
Roswell Park Comprehensive Cancer Center
2023
In ultraviolet (UV) radiation-exposed skin, mutations fuel clonal cell growth. The relationship between UV exposure and the accumulation of (CMs) correlation CMs skin cancer risk are largely unexplored. We characterized 450 individual-matched sun-exposed (SE) non-SE (NE) normal human samples. number relative contribution were significantly different SE NE areas. Furthermore, we identified hotspots in
Abstract Background The precise role of total body 18 F‐fluorodeoxyglucose‐positron emission tomography/computed tomography ( PET / CT ) in the clinical management patients with cutaneous malignant melanoma CMM is not well established. Objective purpose this study was to investigate diagnostic accuracy early‐ and late‐stage high‐risk . Methods We retrospectively analysed various imaging, histopathological data from 97 also examined by during a 5‐year period (2007–2011). Three groups were...
The most important risk factors for malignant melanoma are skin type I or II, large number of atypical naevi and a history sunburn in childhood adolescence.A cross-sectional study was performed to assess type, pigmented lesions sun protection behaviour 1157 12- 19-year-old Hungarian students at 20 primary secondary schools Debrecen, Hungary. After receiving dermatological training, 18 school doctors examined the students' skin. A questionnaire completed by with assistance their parents about...
Summary Background The role of sun exposure in the development melanoma and nonmelanoma skin cancers is known; however, there are limited data on contribution pretransplantation total burden ( TSB ) to increased cancer risk organ transplant recipients OTR s). importance patient education about sun‐safe behaviors understood, but educations often unsuccessful s. Methods A questionnaire‐based cross‐sectional study was performed with kidney patients at a single academic center assess pre‐...
There is a great need for efficient and cost-effective melanoma screening, but this not yet solved. Epidemiological studies on trends in incidence by tumour thickness, anatomical site demographical data can help to improve public health efforts regarding earlier diagnosis. We aimed study the characteristics of patients their North-East Hungary from 2000 2014. Data were obtained university hospital-based registry. A total 1509 cutaneous invasive melanomas 1464 included study. moderate...
Organ transplant recipients (OTR) are more likely to develop skin cancer than the general population. One of main components exposome that triggers development tumours is solar ultraviolet (UV) radiation. To reduce incidence harmful consequences sun exposure, protection education needed for patients taking long-term immunosuppressive drugs.
Actinic keratoses (AKs) and keratinocyte carcinomas (KCs) arise from prolonged UV exposure, with precursor UV-induced clonal mutations (CMs) appearing in sun-damaged skin. Photodynamic therapy (PDT) is a common field treatment for AKs early KCs, but its impact on subclinical CMs unknown. This study examines using targeted ultra-deep sequencing epidermal samples. By comparing skin before after PDT five patients mouse model of chronic carcinogenesis, significant reduction low-frequency...
The development of targeted biologic therapies has led to significant advances in the treatment several immunemediated inflammatory diseases like psoriasis (PsO), psoriatic arthritis (PsA), bowel disease (IBD), rheumatoid (RA), ankylosing spondylitis (AS). By targeting cytokines which play crucial role pathogenesis treated disease, there is disruption hosts innate and adaptive immune response, leading increased risk susceptibility infections, especially fungal infections. Superficial...
The authors present the case of a 59-year-old male patient, whose first kidney transplantation was in 1983 and second 2000. squamous cell carcinoma appeared on skin 2 years after transplantation. Since 2003, at least two precancerous lesions or non-melanoma tumors have been removed surgically yearly. These cancers predominantly sun-exposed skin, were multiple. As these could behave aggressively prone to recurrence, complex treatment applied, which included switch immunosuppressive drugs...
Light-sensitive skin diseases are known as photodermatoses. Photosensitivity is either an increased and/or unusual reaction to normal light, or –as clinical symptoms-. lower dose different composition of light. Genetic and environmental factors have characteristic roles in their development. Symptoms may develop through metabolic, immunological, unknown (idiopathic) mechanisms. In many cases, the avoidance triggering light sun protection important prevention symptoms treatment However,...
Az UV sugárzásnak a photodermatosisok kialakulása mellett döntő szerepe van photocarcinogenesisben és photoagingben is.Az utóbbi évtizedekben fehér bőrű populációban fokozatosan növekszik melanoma nonmelanoma bőrdaganatok incidenciája.Az actinicus kera tosisok, mint laphámsejtes carcinomák prekurzorai, krónikus napfénykárosodás objektív jelzői.Ezt támasztja alá az is, hogy elsősorban napfénynek kitett bőrterületeken fordulnak elő (arc, fülek, kopasz fejbőr, kézhát, alkarok feszítő felszíne)...