A5101917961- Adsorption and biosorption for pollutant removal
- Chromium effects and bioremediation
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Muscle Physiology and Disorders
- Advanced Photocatalysis Techniques
- Microbial Fuel Cells and Bioremediation
- Metal Extraction and Bioleaching
- Radioactive element chemistry and processing
- Copper-based nanomaterials and applications
- Arsenic contamination and mitigation
- Radioactive contamination and transfer
- CO2 Reduction Techniques and Catalysts
- Membrane Separation Technologies
- Neonatal Respiratory Health Research
- Light effects on plants
- Genetic Neurodegenerative Diseases
- Ion channel regulation and function
- Mine drainage and remediation techniques
- Circadian rhythm and melatonin
- Pluripotent Stem Cells Research
- Aquatic Ecosystems and Phytoplankton Dynamics
- Microbial Applications in Construction Materials
- Environmental remediation with nanomaterials
- Clay minerals and soil interactions
First Affiliated Hospital Zhejiang University
2020-2025
Central South University
2019-2025
Chinese National Engineering Research Center for Control and Treatment of Heavy Metal Pollution
2025
Kunming University of Science and Technology
2023-2024
University of Manchester
2020-2024
Zhejiang University
2018-2023
Wuhan University
2018-2022
Northwest A&F University
2022
South Central Minzu University
2020
Ningbo University
2014
The neuromuscular junction (NMJ) is a synapse between motoneurons and skeletal muscles to control motor behavior. Unlike extensively investigated postsynaptic differentiation, less known about mechanisms of presynaptic assembly. Genetic evidence Wnt in mammalian NMJ development was missing due the existence multiple Wnts their receptors. We show when secretion abolished from by mutating ligand mediator (Wls) gene, mutant mice showed muscle weakness neurotransmission impairment. NMJs were...
Expansion of the hexanucleotide repeat GGGGCC in C9orf72 gene is most common genetic factor amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Poly-Gly-Ala (poly-GA), one form dipeptide proteins (DPRs) produced from repeats, tends to neurotoxic protein aggregates. The repeats microglial receptor TREM2 are both associated with risk for ALS/FTD. role regulation C9orf72-ALS/FTD remain unclear. Here, we found that poly-GA activate NLRP3 inflammasome produce interleukin-1β...
Background: As a core symptom of major depressive disorder (MDD), previous magnetic resonance studies have demonstrated that MDD with anhedonia may exhibit distinctive brain structural and functional alterations. Nevertheless, the impact on synchronized alterations in structure function regions remains uncertain. Methods: A total 92 individuals were enrolled study, including 29 patients anhedonia, 33 without 30 healthy controls (HCs). All subjects underwent resting‐state imaging (MRI) scans....
The neuromuscular junction (NMJ) is a synapse between motoneurons and skeletal muscles to control motor behavior. Acetylcholine receptors (AChRs) are restricted at the synaptic region for proper neurotransmission. Mutations in mitochondrial CHCHD10 protein have been identified multiple disorders; however, physiological roles of NMJs remain elusive. Here, we report that highly expressed postsynapse muscles. Muscle conditional knockout mice showed defects, abnormal transmission NMJ structure....
Members of the genus Shewanella are known for their versatile electron accepting routes, which allow them to couple decomposition organic matter reduction various terminal acceptors heterotrophic growth in diverse environments. Here, we report autotrophic oneidensis MR-1 with photoelectrons provided by illuminated biogenic CdS nanoparticles. This hybrid system enables photosynthetic oscillatory acetate production from CO
Abstract Background Neuromuscular junctions (NMJs) are peripheral synapses connecting motoneurons and skeletal myofibers. At the postsynaptic side in myofibers, acetylcholine receptor (AChR) proteins clustered by neuronal agrin signal. Meanwhile, several nuclei each myofiber specially enriched around NMJ for gene transcription. It remains mysterious that how expressions these synaptic systematically regulated, especially motoneurons. Results We found have a distinctive chromatin structure...
Amyotrophic lateral sclerosis (ALS) is a devastating motoneuron disease, in which lower motoneurons lose control of skeletal muscles. Degeneration neuromuscular junctions (NMJs) occurs at the initial stage ALS. Dipeptide repeat proteins (DPRs) from G4C2 repeat-associated non-ATG (RAN) translation are known to cause C9orf72-associated ALS (C9-ALS). However, DPR inclusion burdens weakly correlated with neurodegenerative areas C9-ALS patients, indicating that DPRs may exert cell non-autonomous...