A5045780024- Pituitary Gland Disorders and Treatments
- Silicone and Siloxane Chemistry
- Meningioma and schwannoma management
- Autophagy in Disease and Therapy
- Membrane-based Ion Separation Techniques
- Biofuel production and bioconversion
- biodegradable polymer synthesis and properties
- Neurosurgical Procedures and Complications
- Polymer Nanocomposites and Properties
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Advanced Chemical Sensor Technologies
- Intracranial Aneurysms: Treatment and Complications
- Membrane Separation Technologies
- Biocrusts and Microbial Ecology
- Dementia and Cognitive Impairment Research
- Hepatitis B Virus Studies
- Telomeres, Telomerase, and Senescence
- Catalysis for Biomass Conversion
- Intracerebral and Subarachnoid Hemorrhage Research
- Barrier Structure and Function Studies
- Caveolin-1 and cellular processes
- Burn Injury Management and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Hereditary Neurological Disorders
Second Affiliated Hospital of Zhejiang University
2014-2024
East China University of Science and Technology
2024
University of California, Davis
2018-2022
Nestlé (Switzerland)
2022
Guigang City People's Hospital
2021
Guangxi Medical University
2021
Hangzhou First People's Hospital
2014
Huaqiao University
1999-2003
Tamkang University
2000
Abstract Background Ubiquitination plays an important role in proliferating and invasive characteristic of glioblastoma (GBM), similar to many other cancers. Tripartite motif 25 (TRIM25) is a member the TRIM family proteins, which are involved tumorigenesis through substrate ubiquitination. Methods Difference TRIM25 expression levels between nonneoplastic brain tissue samples primary glioma was demonstrated using publicly available database, immunohistochemistry, western blotting. knockdown...
Abstract Accumulating evidence suggests that changes in the tumor microenvironment caused by radiotherapy are closely related to recurrence of glioma. However, mechanisms which such radiation‐induced involved regrowth have not yet been fully investigated. In present study, how cranial irradiation‐induced senescence non‐neoplastic brain cells contributes glioma progression is explored. It observed senescent facilitated enhancing peripheral recruitment myeloid inflammatory glioblastoma....
The aim of this study is to identify the early predictors for delayed cerebral ischemia (DCI) and develop a risk stratification score by focusing on change after aneurysmal subarachnoid hemorrhage (aSAH).The retrospectively reviewed aSAH patients between 2014 2015. Risk factors within 72 hours were included into univariable multivariable logistic regression analysis screen independent DCI design score.We analyzed 702 patients; four retained from final analysis: World Federation Neurosurgical...
Polyhydroxyalkanoates (PHA) are a family of biodegradable plastics used as an ecofriendly alternative for conventional in various applications. In this study, industrial-scale PHA production system was designed and analyzed the material flows economics with use SuperPro Designer. Haloferax mediterranei utilized to produce poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). Byproduct streams from local cheese plant, input 168.7 metric ton/day (MT/day) lactose, were feedstock. Three scenarios...
Background Transsphenoidal surgery (TSS) is first-line treatment for giant pituitary adenomas (PAs). Although PA a benign neuroendocrine tumor that originates from adenohypophysial cells, the surgical outcomes and prognosis of PAs differ significantly due to multiple factors such as morphology, invasion site, pathological characteristics so on. The aim this study was evaluate in single-center cohort. Methods clinical features 239 patients with who underwent sphenoidal at Second Affiliated...
Background Astrocytes regulate blood-brain barrier (BBB) integrity, whereas subarachnoid haemorrhage (SAH) results in astrocyte dysregulation and BBB disruption. Here, we explored the involvement of tissue inhibitor matrix metalloprotease-1 (TIMP1) astrocyte-mediated protection during SAH, along with its underlying mechanisms. Methods C57BL/6J mice were used to establish a model SAH. The effects TIMP1 on SAH outcomes analysed by intraperitoneal injection recombinant mouse protein (rm-TIMP1;...
Alzheimer disease (AD) is a complex neurodegenerative disorder. Proteomic studies have been instrumental in identifying AD-related proteins present the brain, cerebrospinal fluid, and plasma. This study comprehensively examined 6,905 plasma more than 3,300 well-characterized individuals to identify new proteins, pathways, predictive model for AD. With three-stage analysis (discovery, replication, meta-analysis) we identified 416 (294 novel) associated with clinical AD status findings were...
Pituitary adenoma (PA) is a benign neuroendocrine tumor caused by adenohypophysial cells, and accounts for 10%-20% of all primary intracranial tumors. The surgical outcomes prognosis giant pituitary adenomas measuring ≥3 cm in diameter differ significantly due to the influence multiple factors such as morphology, invasion site, pathological characteristics so on. aim this study was explore risk related recurrence or progression large PAs after transnasal sphenoidal surgery, develop...
Clinically, the low expression of wild-type aryl hydrocarbon receptor-interacting protein (AIP) in patients with sporadic growth hormone (GH)-secreting pituitary adenoma (GHPA) is associated a more aggressive phenotype. However, mechanism by which AIP regulated GHPA remains unclear. Herein, we investigated transcription factor that regulates and explored its role tumor phenotypes.General IIB (GTF2B) was predicted several bioinformatic tools to regulate transcriptionally. Regulation GTF2B...
Abstract Background Isolated onset of intracranial hypertension due to spinal cord tumor is rare, thus, easily leading misdiagnosis and delay in effective treatment. Case presentation Herein, we describe a 45-year-old female patient who manifested isolated symptoms signs whose condition was initially diagnosed as idiopathic transverse sinus stenosis. The received stent implantation; however, no improvements were observed. One year later her exacerbated, during rehospitalization imaging...
Abstract Aim To demonstrate the clinical value of epithelial membrane protein 3 (EMP3) with bioinformatic analysis and data, then to establish a practical nomogram predictive model bicenter validation. Methods The data from CGGA TCGA database were used analyze expression EMP3 its correlation prognosis. Then, we analyzed in samples 179 glioma patients 2013 2017. Univariate multivariate cox regression predict prognosis multiple factors. Finally, poor outcomes was formulated. accuracy...
Highlights Four mechanical manure separators were evaluated in on-farm studies. Mass balances and biochemical methane potential tests conducted to measure separation efficiencies. Separator performance depended on environmental, material, design factors. Over 70% solids emission reduction potentials achieved. Abstract. The efficiencies of four solid-liquid technologies their effect the production from dairy lagoons studied using separator measurements laboratory biomethane tests. included...
The aim of present report was to elucidate the effect cell division cycle associated 4 (CDCA4) on proliferation and apoptosis Wilm's tumor cells, further evaluate its underlying mechanism.The expression profiles CDCA4 clinical information patients were obtained from public Therapeutically Applicable Research Generate Effective Treatments (TARGET) database portal. Real-time qPCR western blot analyses utilized determine levels CDCA4. Gain- loss-of-function assays conducted with transfection...
Enzymatic hydrolysis of sugar beets for achieving liquefaction and release is a critical step beet-ethanol production. An enzyme recycling process was developed in this study to reduce the economic uncertainty raised by high costs enzymes reducing fresh usage. A mixture cellulases pectinases used beet hydrolysis. The hydrolysate centrifuged then processed through 50 kDa molecular weight cut-off polyethersulfone membrane recover from liquid. Liquid with 50% addition achieved similar extent...
Abstract Flexible pressure sensors are crucial for many areas, such as electronic skins, human motion, robot monitoring, and medical treatment. However, conventional manufacturing methods limit the speed accuracy of sensor dielectric layers. In this paper, a unique capacitive with composite structure is introduced that can be fabricated by 3D printing technology. The structure, which has hierarchical pyramids microstructures porous substrate, directly DLP printer. This allows flexible layers...