A5006126349- Cardiac Arrest and Resuscitation
- Cardiac electrophysiology and arrhythmias
- Tuberculosis Research and Epidemiology
- Mechanical Circulatory Support Devices
- Kawasaki Disease and Coronary Complications
- Hydrogen's biological and therapeutic effects
- Cardiac Ischemia and Reperfusion
- Mycobacterium research and diagnosis
- Spectral Theory in Mathematical Physics
- Angiogenesis and VEGF in Cancer
- Numerical methods for differential equations
- Cardiac Arrhythmias and Treatments
- Renin-Angiotensin System Studies
- ECG Monitoring and Analysis
- Transcranial Magnetic Stimulation Studies
- Nonlinear Differential Equations Analysis
- Endoplasmic Reticulum Stress and Disease
- Coronary Artery Anomalies
- Fractional Differential Equations Solutions
- EEG and Brain-Computer Interfaces
- Thermal Regulation in Medicine
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Mathematical Physics Problems
- Traumatic Brain Injury and Neurovascular Disturbances
Army Medical University
2015-2025
Zhejiang University of Technology
2025
China Meteorological Administration
2019-2024
Xi’an University
2024
Shantou University
2018-2023
Army Medical College
2023
Tongji University
2023
First Affiliated Hospital of Shantou University Medical College
2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022-2023
Wenzhou Medical University
2022-2023
The selective cleavage of inert carbon-carbon bonds in unstrained rings continues to pose a formidable challenge chemical synthesis. Current methods for C(sp3)-C(sp3) bond are highly limited, typically relying on transition-metal catalysis facilitate ring-opening via small-ring strain, or inducing β-fragmentation after generating radicals from oxygen nitrogen atoms pre-installed the substrate. In this work, we introduce an effective strategy decarboxylative functionalization α-trisubstituted...
The selective cleavage of inert carbon‐carbon bonds in unstrained rings continues to pose a formidable challenge chemical synthesis. Current methods for C(sp3)‐C(sp3) bond are highly limited, typically relying on transition‐metal catalysis facilitate ring‐opening via small‐ring strain, or inducing β‐fragmentation after generating radicals from oxygen nitrogen atoms pre‐installed the substrate. In this work, we introduce an effective strategy decarboxylative functionalization α‐trisubstituted...
Background Quantitative ventricular fibrillation (VF) analysis has the potential to optimize defibrillation by predicting shock outcomes, but its performance remains unsatisfactory. This study investigated whether combining VF features with parameters could enhance ability of outcome prediction. Methods was electrically induced and left untreated for 30 180 seconds in 55 New Zealand rabbits. A defibrillatory applied 1 9 biphasic waveforms different tilts durations. 4‐step up‐and‐down...
Abstract Dysfunction of neural stem cells (NSCs) has been linked to fetal neuropathy, one the most devastating complications gestational diabetes. Several studies have demonstrated that melatonin (Mel) exerted neuroprotective actions in various stresses. However, role autophagy and involvement Mel NSCs hyperglycemia (HG) not yet fully established. Here, we found HG increased autophagic flux as evidenced by increasing LC3B II/I ratio, Beclin-1 expression, autophagosomes. Moreover, enhanced...
Background Although there was a report about the seasonal variation in Wuhan city, it only analyzed prevalence data of pulmonary tuberculosis (TB) cases, and just studied seasonality by subgroup smear positive negative from 2006 to 2010 spectral analysis. In this study, we investigated total newly notified TB cases subgroups such as time period, sex, age, occupation, district, sputum result 2004 2013 popular adjustment model (TRAMO-SEATS). Methods Monthly were TRAMO-SEATS program. Seasonal...
Endothelial dysfunction is an early hallmark of multiple disease states that also display sex differences with respect to age onset, frequency and severity. Results in vivo studies basal stimulated microvascular barrier function revealed are difficult ascribe specific cells or environmental factors. The present study evaluated endothelial (EC) isolated from macro- and/or microvessels reproductively mature rats under the controlled conditions low-passage culture aiming test assumption EC...
Electroencephalogram (EEG) is a common tool for medical diagnosis, cognitive research, and managing neurological disorders. However, EEG usually contaminated with various artifacts, making it difficult to interpret data. In this study, recursive least square (RLS) notch filter was developed effectively suppress electrocardiogram (ECG) artifacts from recordings. ECG were estimated modeled using the instantaneous frequency of cardiac cycle. Then adaptively RLS directly subtracted Based on...
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common cancers in world and a nonnegligible health concern on worldwide scale. Disulfidptosis novel mode cell death, which mainly caused by collapse actin skeleton. Although many studies have demonstrated that various types death are associated with cancer treatment, relationship between disulfidptosis HCC has not been elucidated. Methods Here, we applied bioinformatics methods to construct related risk model patients....
The role of nitric oxide (NO) in microvascular permeability remains unclear because both increases and decreases by NO synthase (NOS) inhibitors have been reported. We sought to determine whether blood-borne constituents modify venular responses the NOS inhibitor N G -nitro-l-arginine methyl ester (l-NAME). assessed hydraulic conductivity ( L p ) pipette-perfused rat mesenteric venules before after exposure 10 −4 M l-NAME. In absence constituents, l-NAME reduced nearly 50% (from a median 2.4...
Albumin (ALB) level is closely associated with the occurrence of intravenous immunoglobulin (IVIG) resistance and coronary artery lesions (CALs) in Kawasaki disease (KD). The association between ALB CALs progression, critical to prognosis KD patients. But little known about it. This study aims investigate effect on progression patients.A total 3,479 patients from 1 January 2005 30 November 2020, Wenzhou, China were recruited. A 319 who had data, finish follow-up as requested enrolled this...
Gender influences volume regulation via several mechanisms; whether these include microvascular exchange, especially in the heart, is not known. In response to adenosine (Ado), permeability (P(s)) protein of coronary arterioles female pigs decreases acutely. Whether Ado induces similar P(s) changes from males or equivalent responses occur venules either sex has been determined. Hypotheses that 1) basal properties and 2) vasoactive stimuli are independent were evaluated measures two...
ABSTRACT Background: Postcardiac arrest syndrome is the consequence of whole-body ischemia–reperfusion events that lead to multiple organ failure and eventually death. Recent animal studies demonstrated inhalation hydrogen greatly mitigates postresuscitation myocardial dysfunction brain injury. However, influence underlying heart disease on efficacy still unknown. In present study, we investigated effects neurological outcome survival in a cardiac model spontaneously hypertensive rat (SHR)....
Background Myocardial dysfunction is a critical cause of post-cardiac arrest hemodynamic instability and circulatory failure that may lead to early mortality after resuscitation. Trimetazidine metabolic agent has been demonstrated provide protective effects in myocardial ischemia. However, whether trimetazidine protects against postresuscitation unknown. Methods Results Cardiopulmonary resuscitation was initiated 8 minutes untreated ventricular fibrillation Sprague-Dawley rats. Animals were...
Abstract Cardiac arrest leads to sudden cessation of oxygen supply and cerebral hypoxia occurs when there is not sufficient supplied the brain. Current Guidelines for adult cardiopulmonary resuscitation (CPR) emergency cardiovascular care recommend use 100% during resuscitative efforts maximize probability achieving return spontaneous circulation (ROSC). However, optimal strategy management after ROSC still debatable. The aim present study was evaluate effects duration post-resuscitation...
Objective . To investigate the protective effects of resveratrol on kidney uremic rats and to explore whether mechanism is associated with heat shock protein 70 (HSP70) expression. Methods Sixty male Sprague Dawley were randomly separated into 5 groups, including sham group, model different doses group (5 mg/kg, 10 20 mg/kg). The serum creatinine (Cr) urea nitrogen (BUN) levels detected by Automatic Biochemical Analyzer (ABA). pathological changes renal tissues interstitial fibrosis analyzed...
Background Oxygen plays a pivotal role in cardiopulmonary resuscitation (CPR) and postresuscitation intervention for cardiac arrest. However, the optimal method to reoxygenate patients has not been determined. This study investigated effect of timing hyperoxygenation on neurological outcomes arrest/CPR rats treated with targeted temperature management. Methods Results After induction ventricular fibrillation, male Sprague-Dawley were randomized into 4 groups (n=16/group): (1) normoxic...
Since the Beijing 2022 Winter Olympics was first in history held continental winter monsoon climate conditions across complex terrain areas, there is a deficiency of relevant research, operational techniques, and experience. This made providing meteorological services for this event particularly challenging. The China Meteorological Administration (CMA) Earth System Modeling Prediction Centre, achieved breakthroughs research on short- medium-term deterministic ensemble numerical predictions....
Abstract Background The high mortality rates of patients who are resuscitated from cardiac arrest (CA) attributed to post syndrome (PCAS). This study evaluated the effect hyperoxygenation and targeted temperature management (TTM) on PCAS in rats with different causes CA. Methods Results One hundred sixty-eight Sprague-Dawley were equally divided into asphyxial dysrhythmic groups. Animals further randomized four subgroups immediately after resuscitation: 1) Normoxia-normothermia (NO-NT):...
Background: Relapsing polychondritis (RP) is a rare autoimmune disease of unknown etiology that may affect multiple cartilage throughout the body. Case report: We report on middle-aged man presented with cough, chest tightness, and fever origin, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) was performed. And imaging shows increased FDG accumulation in tracheobronchial tree all intercostal cartilages, as well nasal, right auricule, laryngeal...
Abstract The aim of this study was to evaluate long-term survival and risk factors associated with multidrug-resistant tuberculosis (MDR-TB) patient in Central China. Between December 2006 June 2011, incident retreatment adult MDR-TB patients were enrolled the present study. Cox proportional hazard regression analysis used affecting survival. total follow-up period 270 person-years (PY) for 356 cases Wuhan. Of cases, 103 died, yielding an average case fatality rate 381.2 per 1000 TB year....
Abstract Purpose Previous clinical studies have suggested an effect of gender on outcome after out-of-hospital cardiac arrest, but the results are conflicting and there is no uniform agreement regarding differences in survival prognosis. The present study was aimed to investigate interaction between post resuscitation interventions neurological asphyxial rat model arrest. Methods Asphyxia induced by blocking endotracheal tube 120 adult Sprague–Dawley rats (60 males 60 females) at same age....
Single-walled carbon nanotubes (SWCNTs) have been proposed to great therapeutic potential. SWCNTs conjugated with drugs or genes travel in the systemic circulation reach target cells tissues following extravasation from microvessels although interaction between SWCNT conjugates and microvascular endothelial (ECs) remains unknown. We hypothesized that SWCNT-DNA would be taken up by ECs this process facilitated compared facilitation DNA alone. were treated various concentrations of...
Abstract This paper is mainly devoted to the study of one kind nonlinear Schrödinger differential equations. Under integrable boundary value condition, existence and uniqueness solutions this equation are discussed by using new Riesz representations linear maps fixed point theorem.