A5100732356- Tuberculosis Research and Epidemiology
- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Mycobacterium research and diagnosis
- Advanced Battery Technologies Research
- Electrolyte and hormonal disorders
- Advanced Algorithms and Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- Pneumonia and Respiratory Infections
- Liver Disease and Transplantation
- Electric and Hybrid Vehicle Technologies
- Cancer-related molecular mechanisms research
- Potassium and Related Disorders
- Fuel Cells and Related Materials
- RNA modifications and cancer
- Soil Carbon and Nitrogen Dynamics
- Infectious Diseases and Tuberculosis
- Food Allergy and Anaphylaxis Research
- Arsenic contamination and mitigation
- Muscle and Compartmental Disorders
- Renal Diseases and Glomerulopathies
- Power Systems and Renewable Energy
- Autoimmune Bullous Skin Diseases
- Legume Nitrogen Fixing Symbiosis
- Biomedical and Chemical Research
Wuhan Pulmonary Hospital
2020-2024
Air Force Medical University
2010-2024
Xijing Hospital
2012-2024
Jianghan University
2024
Fujian Academy of Medical Sciences
2024
Weatherford College
2022
Harbin University of Science and Technology
2022
Harbin University
2008
Northwestern University
2005
Abstract Anticancer drug like Cisplatin are associated with serious problem nephrotoxicity. The effect of Kaempferol is a plant-derived flavonoid compound. present work evaluated the in mouse model mediated nephrotoxicity also involved mechanism. Oxidative stress, kidney function, histology, inflammation, apoptosis, level proteins, Nrf2 translocation and its on cascades such as NF-κB ERK were studied. It was observed that pre-treatment KPF reduced oxidative apoptosis ameliorated renal injury...
Abstract Cuproptosis plays an important role in cancer, but its lung cancer remains unknown. Transcriptional profiles, clinical details and mutation data were acquired from the Cancer Genome Atlas database through a variety of methods. The analysis this publicly available was comprehensively performed using R software along with relevant packages, ensuring thorough examination information. In study, we conducted detailed cuproptosis‐related genes lncRNA co‐expression, identifying 129 lncRNAs...
Background The opinions on the efficacy and safety of no anticoagulation versus regional citrate for continuous KRT (CKRT) were controversial in patients with severe liver failure a higher bleeding risk. We performed randomized controlled trial to assess CKRT these patients. Methods Adult risk who required considered candidates. included participants receive or no-anticoagulation CKRT. primary end point was filter failure. Results Of participants, 44 45 CKRT, respectively. group had...
Abstract Pseudostellaria heterophylla of the Caryophyllaceae family is an important medicinal herb in traditional Chinese medicine, but it encounters continuous cropping obstacle during cultivation. This study aimed to differences response cultivation soil microorganisms and phenolic substances different types (Loamy Clayey soil). The analysis metabolites using HPLC-ESI-Q/TOF-MS HPLC-DAD techniques revealed that content various components rhizosphere increased significantly after yellow...
Epithelial-to-Mesenchymal Transition (EMT) induced by glucose in human peritoneal mesothelial cells (HPMCs) is a major cause of membrane (PM) fibrosis and dysfunction.To investigate serum response factor (SRF) impacts on EMT-derived PM, we isolated HPMCs from the effluents patients with end-stage renal disease (ESRD) to analyze alterations during dialysis (PD) observe PM SRF rat model.Our results demonstrated activation translocation into nuclei under extensive periods PD. Accordingly, lost...
Background Wuhan is located in the hinterland of China, east Hubei Province, at intersection Yangtze River and Hanshui River. It a national historical cultural city, an important industrial, scientific, educational base, key transportation hub. There are many schools Wuhan, with nearly thousand all kinds. The number students ~2.2 million, accounting for one-fifth resident population; college or university account ~60% total student population. geographical location these colleges relatively...
Objective There are controversial opinions on anticoagulation for continuous venovenous hemofiltration (CVVH) in patients with liver failure (LF) and increased bleeding risk. Therefore, we conducted a retrospective study to evaluate the efficacy safety of regional citrate (RCA) versus no-anticoagulation CVVH these patients. Methods The included were divided into RCA group according strategy they accepted CVVH. Filter lifespan, bleeding, accumulation, catheter occlusion, totCa/ionCa ratio...
Abstract Background Tuberculosis (TB) is a leading infectious cause of morbidity and mortality worldwide. However, delay in health care seeking has remained unacceptably high. The aim this study was to clarify the trend patient its associated risk factors during rapid aging urbanization Wuhan, China from 2008 2017. Methods A total 63,720 TB patients registered at Wuhan Information Management System January December 2017 were included. Long (LPD) defined as longer than 14 days. Independent...
Xerostomia is a self-conscious symptom. High-mobility group box 1 (HMGB1) promotes pro-inflammatory effects in many diseases. This study aimed to clarify the role of HMGB1 Sjögren syndrome (SS)-triggered xerostomia. Nonobese diabetic (NOD)/Ltj mice were used establish an SS-triggered xerostomia model. The results showed that saliva production was decreased and anti-Sjögren B (anti-SSB) level increased SS. PCR, Western blot, immunohistochemistry experiments indicated aquaporin 5 (AQP5) levels...
Abstract The aim of this study was to evaluate long-term survival and risk factors associated with multidrug-resistant tuberculosis (MDR-TB) patient in Central China. Between December 2006 June 2011, incident retreatment adult MDR-TB patients were enrolled the present study. Cox proportional hazard regression analysis used affecting survival. total follow-up period 270 person-years (PY) for 356 cases Wuhan. Of cases, 103 died, yielding an average case fatality rate 381.2 per 1000 TB year....
Patients with severe hypernatremia who receive conventional treatment are often undertreated. Data on the management of acute using continuous venovenous hemofiltration (CVVH) limited to anecdotes. This study aimed evaluate efficacy and safety CVVH for in critically ill patients a retrospective cohort. A total 95 were admitted our ICU between January 2009 2014 analyzed as original These divided into groups. The groups then matched by age, reason admission, vasopressor dependency, basic serum...
How multidrug-resistant tuberculosis (MDR-TB) spreads and expands in Wuhan population is not clear. The study aimed to determine the transmission patterns of MDR-TB city, China, including 149 patients with MDR-TB.Tuberculosis isolates were genotyped by deletion-targeted multiplex polymerase chain reaction, mycobacterial interspersed repetitive unit-variable number tandem repeat typing, sequencing drug resistance-associated genes. risk factors genomic-clustering analyzed logistic regression....
In a doubly-fed induction generator (DFIG)-based wind energy conversion system (WECS), when the grid voltage sags severely, rotor side converter (RSC) suffers from overvoltage and overcurrent owing to large electromotive force (EMF). To ensure that operates within safe range faults occur, this paper proposes double impedance-substitution control (DISC) strategy improve system’s low-voltage ride through (LVRT) capability. When sag is detected, (GSC) RSC are connected in parallel circuit by...
The current treatments of toxic epidermal necrolysis (TEN) are limited to the discontinuation a suspect medication and supportive measures. We conducted retrospective study evaluate efficacy adding continuous venovenous hemofiltration (CVVH) hemoperfusion (HP) conventional treatment for TEN.TEN patients who were admitted our center between January 2008 May 2016 considered as candidates. included divided into CVVH&HP group (n = 34) according their accepted therapies during hospital stay.The...
Abstract Intraperitoneal inflammation is the most important determinant of peritoneal fibrosis in patients with long-term dialysis (PD). Spliced x-box binding protein-1 (XBP1s), a major proximal effector unfolded protein response (UPR) signaling, plays an indispensable role inflammation. Our study demonstrated that inflammatory factor interleukin-1β (IL-1β) dose- and time-dependently induced XBP1s upregulation interleukin-6 (IL-6) secretion, as well expression fibrotic marker fibronectin....
Drug-resistant tuberculosis (TB) continues to be a public health threat. There are few studies on transmission and genotyping of MDR-TB family households in China. This study aimed investigate multidrug-resistant (MDR-TB) within by deletion-targeted multiplex polymerase chain reaction (DTM-PCR), mycobacterial interspersed repetitive unit variable number tandem repeats (MIRU-VNTR) genotyping.Among 993 patients registered from Wuhan Institute for Tuberculosis Control, drug resistance the time...
To accomplish the demand of minimum fuel consumption and good power performance for continuously variable transmission (CVT) car. Aiming at whole vehicle model including engine, clutch CVT, dynamics mathematical CVT system is established according to different stages engaging, that dynamic integrated simulation developed. A parameter self-adjusting speed ratio fuzzy controller devised typical operation states car are simulated results analyzed in detail. The indicate has control effect...