A5057681906- Helicobacter pylori-related gastroenterology studies
- Land Use and Ecosystem Services
- Galectins and Cancer Biology
- Hepatitis B Virus Studies
- Wildlife-Road Interactions and Conservation
- Urban and Freight Transport Logistics
- Conservation, Biodiversity, and Resource Management
- Regional Economics and Spatial Analysis
- Immunotherapy and Immune Responses
- Urban Transport and Accessibility
- Gut microbiota and health
- Hepatitis Viruses Studies and Epidemiology
- Glycosylation and Glycoproteins Research
- Urban Design and Spatial Analysis
- Phytochemistry and Bioactive Compounds
- Cytokine Signaling Pathways and Interactions
- Diabetes Treatment and Management
- Gastroesophageal reflux and treatments
- Consumer Retail Behavior Studies
- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Veterinary medicine and infectious diseases
- Hepatitis C virus research
Peking University
2018-2024
Peking University Third Hospital
2022-2024
The persistence of HBV covalently closed circular DNA (cccDNA) and integration into the host genome in infected hepatocytes pose significant challenges to cure chronic infection. Although CRISPR/Cas9-mediated editing shows promise for targeted clearance viral genomes, a safe efficient delivery method is currently lacking. Here, we developed novel approach by combining light-induced heterodimerization protein acylation enhance loading efficiency Cas9 extracellular vesicles (EVs). Moreover,...
Background & AimsHBsAg loss is only observed in a small proportion of patients with chronic hepatitis B (CHB) who undergo interferon treatment. Investigating the host factors crucial for CHB functional cure can aid identifying individuals would benefit from Peginterferon-alpha (Peg-IFNα) therapy.MethodsWe conducted Genome-wide association study (GWAS) by enrolling 48 HBsAg and 47 persistence after Peg-IFNα In validation stage, we included total 224 samples, out which 90 achieved loss, to...
Upon a single subcutaneous injection, IFN-ELP <italic>in situ</italic> forms depot, leading to one-month sustained release and dramatically enhanced tumor therapy.
Abstract Background CKLF-like MARVEL transmembrane domain containing 3 (CMTM3) plays an important role in cancer development. Although Helicobacter pylori ( H. ) infection is a main cause of gastric cancer, the function CMTM3 during remains unclear. expression levels tissues from pylori- infected patients and cells co-cultured with were analyzed. qRT-PCR ELISA used to investigate effects on interleukin 8 (IL-8) expression. Annexin V/propidium iodide staining was performed evaluate apoptosis...
The New Retail is an emerging e-commerce model in recent years. It claims innovation creating competitive advantages through intensive Internet-based data to promote online-to-offline interactions. Whether this self-claimed would cause a different rationale the choice of store locations subject worthy investigation. In article, taking Beijing's Starbucks and Luckin coffee stores as cases, we build two-layer business location examine problem. consists macroscale (city-wide) submodel...
Tibetan medicine has been used in clinical practice for more than 3800 years. Zuozhu-Daxi (ZZDX), a classic traditional medicine, proved to be effective the treatment of digestive diseases, such as chronic gastritis, gastric ulcer, etc. Helicobacter pylori (H. pylori), one most common pathogenic microbes, is regarded cause gastritis. Researching on effects ZZDX H. pylori-induced mucosa inflammation could provide evidences and promote development medicine. This study aimed explore whether...
Abstract Background Helicobacter pylori infection is one of the main causes gastric cancer. thioredoxin‐1 (Trx1) and arginase (RocF) expressed by H. were found to be closely related its pathogenicity. However, whether Trx1 RocF can used in clinical screening highly pathogenic pathogenesis trx1 high expressing remain still unknown. Materials Methods We investigated expression level rocF human antrum tissues using reverse transcription quantitative real‐time PCR (RT‐qPCR) clarified application...
e15523 Background: Detection and excision of early-stage CRC or colorectal precancerous lesions (advanced adenoma) has been recognized as an effective way to reduce induced mortality. Integrating signals from both tumoral tissues microenvironment exhibit better accuracy for tumor detection, especially tumors. Gut microbiome carried out profound effects on initiation progression cancer adenoma, our previous findings have also revealed that gut microbiome-associated serum metabolites exhibited...
Many ecosystem service (ES) items, such as the wind erosion prevention (WEPS), have spatially separated provision and benefit areas (SPA & SBA), which are connected by directional services flows (ESF). Clarifying specific spatial relationships between SPA SBA is of potential scientific policy importance for flow-conveyed ES. Much existing research has focused on identification based a given SPA. However, due to asymmetry supply-based demand-based ESFs geospatial heterogeneity, this...
Chronic hepatitis B virus (HBV) infection due to perinatal mother-to-infant transmission (MTIT) remains a serious global public health problem. It has been shown that intrauterine exposure HBV antigens might account for the MTIT-related chronic infection. However, whether surface antigen (HBsAg) affected offspring's immune response against and MTIT of not fully clarified. In this study, we investigated effects potential mechanisms HBsAg on persistence replication using solely mice model. Our...
Introduction Refractory peptic ulcers lead to perforation and hemorrhage, which are fatal. However, these remain a therapeutic challenge. Gastric mucosal blood flow is crucial in maintaining gastric health. It’s reported that Glucagon-like peptide-2 (GLP-2), gastrointestinal hormone, stimulated intestinal flow. the direct role of GLP-2 metabolites unclear. Here, we speculated might protect mucosa by increasing regulating metabolites. This study was conducted evaluate lesions its underlying...
Background: Classic locational principles predict a picture of urban intensity decaying from the city center to periphery under ideal assumptions. However, various exogenous factors can influence real-world and often deviate theoretical pattern. The specific mechanisms are worthy exploration potential practical significance. Methods: In this paper, we consider two districts with typical locations, namely, Changping Chaoyang in Beijing, construct mechanistic models status quo (floor area...
Abstract Context The value realization of the ecosystem services (ES) with directional service flows (ESF) is sensitive to way ES supply and demand are spatially coupled, which nature propagation dynamics ESFs mechanisms effective generation remain be clarified. Objectives paper focuses on a typical directionally flowed urban ES, park-recreational service, proposes formal model for analyzing its mechanism, discerns contribution distance-decaying from that demand-side factors. A cellular...