A5054943660- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- BRCA gene mutations in cancer
- Genomics and Rare Diseases
- Cancer-related cognitive impairment studies
- Health, Environment, Cognitive Aging
- Mitochondrial Function and Pathology
- COVID-19 and healthcare impacts
- Glioma Diagnosis and Treatment
- Electron Spin Resonance Studies
- Genetics and Neurodevelopmental Disorders
- Cardiovascular Function and Risk Factors
- Diabetic Foot Ulcer Assessment and Management
- Chronic Disease Management Strategies
- Genomics and Chromatin Dynamics
- Chromatin Remodeling and Cancer
- Cancer survivorship and care
- Cancer-related gene regulation
- Plant Reproductive Biology
- Biochemical and Molecular Research
- Silymarin and Mushroom Poisoning
- HER2/EGFR in Cancer Research
- 14-3-3 protein interactions
- Chromosomal and Genetic Variations
- Plant biochemistry and biosynthesis
Hunan Normal University
2024-2025
Hunan Provincial People's Hospital
2024-2025
St. Jude Children's Research Hospital
2023-2025
Hunan Provincial Center for Disease Control and Prevention
2025
Anhui Agricultural University
2018-2025
University of Delaware
2020-2024
Disco (Germany)
2024
Weatherford College
2024
Newark Hospital
2020
Northwest A&F University
2016
Abstract Childhood cancer survivorship studies generate comprehensive datasets comprising demographic, diagnosis, treatment, outcome, and genomic data from survivors. To broadly share this data, we created the St. Jude Survivorship Portal (https://survivorship.stjude.cloud), first portal for sharing, analyzing, visualizing pediatric data. More than 1,600 phenotypic variables 400 million genetic variants more 7,700 childhood survivors can be explored on free, open-access portal. Summary...
Abstract Medulloblastoma (MB) is one of the most malignant pediatric brain tumors. Molecularly, MB separates into four subgroups—WNT, SHH, Group 3 (G3), and 4 (G4)—each with unique clinical features genetic profiles. WNT tumors have best survival outcomes low metastatic potential, whereas G3 exhibit highest malignancy poorest outcomes. While SHH are highly distinct, G4 interrelated when grouped together, these referred to as G3/G4 These genetically complex, a constellation molecular...
Heat stress has a significant negative impact on plant growth, development, and yield. The cell wall, key structural feature that sets plants apart from animals, not only acts as the first physical barrier against heat but also plays an active role in (HS) response through signaling pathways. wall complex composition, including cellulose, hemicellulose, lignin, pectin. These components provide mechanical support for growth constitute material basis to environmental changes. This review...
High-grade gliomas (HGG) in young children pose a challenge due to favorable but unpredictable outcomes. While retrospective studies broadened our understanding of tumor biology, prospective data is lacking.
DM and PM were the two major subtypes in myositis; among which, a unique metabolomic biomarker profile remains lacking. Serum from 36 diagnosed myositis patients (28 8 PM) 29 healthy controls was analyzed using HPLC-Q-TOF-MS/MS. PLS-DA conducted through MetaboAnalyst 5.0 to identify differential metabolites. The KEGG analysis utilized observe related metabolic pathways. potential value assessed ROC analysis. relationship between clinical characteristics levels of identified metabolites R...
Abstract Background Survival data for recurrent pediatric atypical teratoid rhabdoid tumor (ATRT) and its association to molecular groups are extremely limited. Methods Single‐institution retrospective study of 64 children less than 21 years old with or treatment‐refractory (progressive disease [PD]) ATRT treated at St. Jude Hospital from January 2000 December 2020. Demographic, clinicopathologic, treatment, grouping (SHH, TYR, MYC) germline were collected. Progression‐free survival (PFS2:...
Mutations in the RNA helicase DDX3 have emerged as a frequent cause of intellectual disability humans. Because many patients carrying mutations additional defects craniofacial structures and other tissues containing neural crest (NC)-derived cells, we hypothesized that is also important for NC development. Using Xenopus tropicalis model, show required normal induction morphogenesis by regulating AKT kinase activity. Depletion decreases activity AKT-dependent inhibitory phosphorylation GSK3β,...
Ephrin-B signaling has been implicated in many normal and pathological processes, including neural crest development tumor metastasis. We showed previously that proteolysis of ephrin-B ligands by the disintegrin metalloprotease ADAM13 is necessary for canonical Wnt signal activation induction Xenopus, but it was unclear if these mechanisms are conserved mammals. Here, we report mammalian ADAM9 cleaves ephrin-B1 ephrin-B2 can substitute Xenopus to induce crest. found expression elevated human...
Diphthamide is a modified histidine residue unique for eukaryotic translation elongation factor 2 (eEF2), key ribosomal protein. Loss of this evolutionarily conserved modification causes developmental defects through unknown mechanisms. In patient with compound heterozygous mutations in Biosynthesis 1 (DPH1) and impaired eEF2 diphthamide modification, we observe multiple neural crest (NC)-derived tissues. Knockin mice harboring the patient's Xenopus embryos Dph1 depleted also display NC...
Amanita phalloides poisoning, renowned for its high mortality rates, is one of the most serious food safety issue in certain regions worldwide. Assessment prognosis and development more efficacious therapeutic strategies are critical importance amanita poisoning patients. The aim study to establish a nomogram predict clinical outcome patients based on independent risk factor prognosis. Herein, between January 2013 September 2023, cohort 149 diagnosed with was enrolled randomly allocated into...
There is distinctive advantage of using male sterile lines to breed new cultivar and produce hybrids, when compared with general breeding method on yield quality. In our previous work, near-isogenic (NILs) fertile Salvia miltiorrhiza have been obtained through continuous hybridization in many years. this investigation, 378 primer combination were screened by AFLP BSA technique, which 26 markers amplified from seven primers found tightly link gene. Based these markers, two linkage genetic...
Male sterility is a common phenomenon in flowering plants, and it has been widely used hybrid seed production number of economically important crops.
Abstract Survivors of childhood cancer are at risk for developing various adverse health conditions as adults that attributable to the and treatments they were exposed children. Cancer survivorship research relies on large-scale, longitudinal studies generate a wide range demographic, clinical, genetic data survivors. Nevertheless, absence portals has made it challenging broadly share data. We have created St. Jude Survivorship Portal (https://survivorship.stjude.cloud), first portal...
Background: Survival data for recurrent or treatment refractory pediatric atypical teratoid rhabdoid tumor (AT/RT), and its association to molecular groups is extremely limited. Methods : Single-institution retrospective study of sixty-four children <21 years old with AT/RT that was frontline therapies (PD) treated at St. Jude Children’s Research Hospital from January 2000 December 2020. Demographic, clinicopathologic, treatment, grouping (SHH, TYR MYC) germline SMARCB1/SMARCA4 mutational...
<p>Supplementary Notes</p>
<p>Exporting data for haplotype analysis</p>
<p>Workflow for building custom groups</p>
<p>User interface for genetic association analysis on the portal</p>
<p>Ototoxicity of platinum-based chemotherapy in the CCSS cohort</p>
<p>Association between ARID5B variants and ALL in African European ancestries</p>