A5011893081- Metastasis and carcinoma case studies
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- Occupational and environmental lung diseases
- Gestational Trophoblastic Disease Studies
- Adenosine and Purinergic Signaling
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Multiple and Secondary Primary Cancers
- Cancer, Hypoxia, and Metabolism
- Alzheimer's disease research and treatments
- Family Support in Illness
- Genetic factors in colorectal cancer
- Cancer-related gene regulation
- Erythrocyte Function and Pathophysiology
- Tumors and Oncological Cases
- PI3K/AKT/mTOR signaling in cancer
- Polyamine Metabolism and Applications
- Ectopic Pregnancy Diagnosis and Management
- Cleft Lip and Palate Research
- Cellular Mechanics and Interactions
- Congenital Anomalies and Fetal Surgery
- Genomics, phytochemicals, and oxidative stress
- Pregnancy and preeclampsia studies
- Pulmonary Hypertension Research and Treatments
Sichuan University
2025
Chongqing Medical University
2024
Children's Hospital of Chongqing Medical University
2024
Zhengzhou Central Hospital
2021-2023
Sichuan Cancer Hospital
2017
University of Electronic Science and Technology of China
2017
Southern Medical University
2013
Nanfang Hospital
2013
Zhengzhou University
2008-2012
Abstract tRNA N7-methylguanosine (m7G) is one of the most abundant epigenetic modifications in mammals, which catalyzed by methyltransferase 1-WD repeat-containing protein 4 (METTL1-WDR4) complex. Missense mutations WDR4 have been linked to primordial dwarfism, shows severe craniofacial developmental deformities including small teeth, but underlying molecular mechanisms remain elusive. In this study, we explore effect m7G modification on dentin formation during tooth root development. METTL1...
Protein 4.1N belongs to the protein 4.1 superfamily that links transmembrane proteins actin cytoskeleton. Recent evidence has shown is important in tumor suppression. However, functions of metastasis breast cancer are largely unknown. In present study, MCF-7, T-47D and MDA-MB-231 cell lines with various metastatic abilities were employed. was found be expressed poorly MCF-7 middle lines, predominantly associated cell-cell junctions. no expression detected highly cells. Moreover,...
Pulmonary endothelial dysfunction plays an integral role in the pathogenesis and development of pulmonary hypertension. It is difficult inconvenient to obtain arterial cells (PAECs) from humans large animals. Some methods for isolation PAECs rats require complex equipment expensive reagents. In this study, we describe a new method obtaining cultures isolated rat arteries with Chinese acupuncture needles. We acquired 5 steps. These were: arteries, exposure endothelium, enzymatic digestion,...
Diphthamide is a modified histidine residue unique for eukaryotic translation elongation factor 2 (eEF2), key ribosomal protein. Loss of this evolutionarily conserved modification causes developmental defects through unknown mechanisms. In patient with compound heterozygous mutations in Biosynthesis 1 (DPH1) and impaired eEF2 diphthamide modification, we observe multiple neural crest (NC)-derived tissues. Knockin mice harboring the patient's Xenopus embryos Dph1 depleted also display NC...
Rationale: Epithelioid trophoblastic tumor (ETT) is a distinctive but rare gestational neoplasia (GTN) composed of chorionic-type intermediate trophoblast cells. Approximately 50% ETT arose from the uterine cervix or lower segment following previous pregnancy with vaginal bleeding. With its unusual ability to simulate an invasive epithelioid neoplasm, frequently poses diagnostic challenge, especially involving cervix. Patient concerns: We herein report case 60-year-old female persistent...
目的： 观察洪水浸泡后的蜡块对HE染色、免疫组织化学标记及分子病理检测的影响，评估受损的病理蜡块是否有保存价值及能否满足后续检测要求。 方法： 清洗蜡块表面淤泥，消毒液浸泡，自然干燥后，选取不同年份、不同标本类型的蜡块，行HE染色、免疫组织化学标记及分子病理检测，与之前档案中的检测结果进行对比，观察前后检测结果的差别。 结果： HE染色镜下显示细胞胞质和胞核红蓝对比明显，着色均匀，细胞结构清晰；免疫组织化学染色显示阳性结构清晰，定位准确；分子病理检测结果与之前结果一致。 结论： 病理档案资料保存中，组织前期处理及封蜡非常关键，极端情况下能最大限度保障病理组织的完整性。.
目的： 探讨具有间皮瘤样生长方式的肺腺癌的临床病理学特征。 方法： 收集3例具有间皮瘤样生长方式的肺腺癌患者的临床病理资料，并复习相关文献。 结果： 3例患者均为男性，年龄68~73岁，平均年龄70岁，均有咳嗽、胸闷及气喘症状，2例伴胸腔积液，CT显示胸膜不均匀增厚，而肺内均未见明确肿块。镜下观察3例均见纤维组织中大量上皮样肿瘤细胞浸润，呈实性片状分布，部分区域可见腺样结构，胞质丰富、略嗜碱性，核圆形或卵圆形，核染色质较疏松，部分细胞可见核仁，核分裂象偶见。免疫组织化学显示肿瘤细胞均表达广谱细胞角蛋白、细胞角蛋白（CK）7、甲状腺转录因子1、表面活性蛋白B、上皮细胞膜抗原，局部表达Napsin A，均不表达CK5/6、p40、D2-40、WT1、结蛋白、HBME1、Calretinin、PAX8，SMARCA4、SMARCB1均无缺失。3例患者非小细胞肺癌相关基因检测均未发现突变。 结论： 具有间皮瘤样生长方式的肺腺癌，临床表现及形态学与恶性胸膜间皮瘤相似，预后差，确诊依赖胸腔镜胸膜活检病理诊断。.