A5101690151- Child and Adolescent Psychosocial and Emotional Development
- Child Abuse and Trauma
- Acute Lymphoblastic Leukemia research
- Single-cell and spatial transcriptomics
- Maternal Mental Health During Pregnancy and Postpartum
- Acute Myeloid Leukemia Research
- Chinese history and philosophy
- Resilience and Mental Health
- Cancer Genomics and Diagnostics
- Mental Health and Patient Involvement
- Family and Disability Support Research
- Renal function and acid-base balance
- Gastroesophageal reflux and treatments
- Intergenerational Family Dynamics and Caregiving
- Family Support in Illness
- Attachment and Relationship Dynamics
- Virology and Viral Diseases
- Retinoids in leukemia and cellular processes
- Memory and Neural Mechanisms
- Parental Involvement in Education
- Youth Education and Societal Dynamics
- Epistemology, Ethics, and Metaphysics
- Substance Abuse Treatment and Outcomes
- Intimate Partner and Family Violence
- Educational Strategies and Epistemologies
University College London
2020-2025
Anna Freud Centre
2020-2025
Children's Hospital of Philadelphia
2021-2024
Pharmaceutical Product Development (United States)
2021
The University of Texas Southwestern Medical Center
2021
Yale University
2021
Schneider Children's Hospital
2020
Cohen Children's Medical Center
2020
University of Edinburgh
2019
Simon Fraser University
2017
Epistemic trust (ET) refers to in communicated knowledge. This paper describes the development and validation of a new self-report questionnaire, Trust, Mistrust Credulity Questionnaire (ETMCQ). We report on two studies (Study 1, n = 500; Study 2, 705) examining psychometric properties ETMCQ relationship between EMTCQ scores (i.e., an individual’s epistemic stance) exposure adverse childhood experiences, mental health symptoms, attachment, mentalizing general self-efficacy. The factor...
Sepsis and acute lung injury (ALI) have devastatingly high mortality rates. Both are associated with increased vascular leak, a process regulated by complex molecular mechanisms.We hypothesized that integrin αvβ3 could be an important determinant of leak endothelial permeability in sepsis ALI.β3 subunit knockout mice were tested for after endotracheal LPS, systemic intraperitoneal LPS cecal ligation puncture. Possible contributory effects β3 deficiency platelets other hematopoietic cells...
Although the theory of epistemic trust has started informing research in clinical populations and psychotherapy, no study yet explored phenomenon mistrust depressed adolescents receiving psychotherapy. The present aims to address this gap by creating a typology adolescents' experiences regarding their different journeys through course psychotherapy relation issues over 2-year period. This is based on post hoc analysis interview data collected for broader purpose. A total 45 semistructured...
Objective Patients with epistemic mistrust struggle to view others as trustworthy sources of knowledge and often default negative appraisals in social communication. The three communication systems theory posits that resolving involves systems: the match, improving mentalizing, re-emergence learning outside therapy. This study aimed empirically examine understand how trust develops psychotherapy.
A phase I/II trial of a candidate vaccine to prevent HIV infection was carried out in Bangkok, Thailand, testing AIDSVAX B/E (VaxGen, Inc., Brisbane, CA), bivalent subunit prepared by combining recombinant gp120 from subtype B virus (HIV-1MN) with E (HIV-1A244) alum adjuvant. The studies provide human data on the immunogenicity various dose combination non-subtype antigens. results suggest that is safe and immunogenic humans. optimal for humans developing countries 300 microg each antigen (B...
Novel psychological theories are often conceived in a general or heuristic form that can benefit from development and granulation through context-specific theory testing. Here, theory-testing single case study methodology, adapted an approach developed the field of psychoanalysis, is presented. The exemplifies this methodology though interrogation explanatory value relatively new child theory, epistemic trust, context relationship between foster carer ("John") young person their care...
Objective This qualitative study explores patients' experiences of psychotherapy, focusing on elements perceived as helpful or unhelpful and suggestions for improvement in the context public mental health care.
<title>Abstract</title> T-lineage acute lymphoblastic leukemia (T-ALL) is a high-risk tumor that has eluded comprehensive genomic characterization, in part due to the high frequency of non-coding alterations resulting oncogene deregulation. Here we report integrated genome and transcriptome sequencing T-ALL remission samples obtained from over 1300 uniformly treated children with T-ALL, coupled epigenomic single cell analysis malignant normal T precursors. Integrated identified 15 subtypes...
<title>Abstract</title> Refractoriness to initial chemotherapy and relapse after remission are the main obstacles cure in T-cell Acute Lymphoblastic Leukemia (T-ALL). Biomarker guided risk stratification targeted therapy have potential improve outcomes high-risk T-ALL; however, cellular genetic factors contributing treatment resistance remain unknown. Previous bulk genomic studies T-ALL implicated tumor heterogeneity as an unexplored mechanism for failure. To link subpopulations with...
There are two main factors that have contributed to the emergence of a modern educational phenomenon known as "Chinese Leaner." The learner" is described as, "...being obedient authority, passive in class, lacking critical thinking, and adopting inadequate learning strategies" (Clark & Gieve, 2006, p. 54). concept Learner" cannot be understood without understanding historical cultural roots precede its emergence. This paper will address sociopolitical influences may underlie descriptions...
Veverimer is a polymer being developed as potential treatment of metabolic acidosis in patients with chronic kidney disease. selectively binds and removes hydrochloric acid from the gastrointestinal tract, resulting an increase serum bicarbonate. not systemically absorbed, so drug-drug interactions (DDIs) are limited to effects on absorption other oral drugs through binding veverimer tract or increases gastric pH caused by acid. In vitro experiments using panel 16 test drugs, no positively...
Abstract The hippocampus and the striatum represent two major systems in brain for learning, memory navigation. Although they were traditionally considered as parallel responsible distinct types of learning or navigation, increasing evidence indicates a close synergetic competitive interaction between them. Both consist multiple anatomical functional domains. Besides limited direct projection from to ventral striatum, most them may be mediated by polysynaptic projections. Polysynaptic...
Background: Bullying is a widespread problem that can take various forms. not only adversely affects self-esteem in childhood but also lead to mental health problems during and beyond. Studies have demonstrated children with adverse experiences (ACE) are at increased risk be victim of bullying (VoB) and/or bully others. Although parenting style home environment important mediating factors respect bullying, it unclear whether “family resilience” may mitigate the negative effects ACEs....