Multiple clinical and preclinical studies have reported a signal intensity increase the presence of gadolinium (Gd) in brain after repeated administration Gd-based contrast agents (GBCAs). This bioanalytical study rat tissue was initiated to investigate whether residual Gd is present as intact GBCA or other chemical forms by using fractionation chromatography.Rats were divided randomly 6 groups 10 animals each. They received daily injections 2.5 mmol/kg bodyweight 1 5 different GBCAs: linear...

Several recent publications have suggested an association between the administration of gadolinium (Gd)-based contrast agents and occurrence Nephrogenic Systemic Fibrosis (NSF), acquired disorder marked by skin thickening fibrosis occurring in patients with severe renal dysfunction. The aim this study was to establish a preclinical experimental setting investigate possible link NSF Gd-based agents, specifically role Gd and/or depletion endogenous metal ions as triggers for NSF.Thirty-five...

Recent reports suggest that nephrogenic systemic fibrosis (NSF) is associated with the administration of gadolinium (Gd)-based contrast agents (GBCAs) and in particular stability Gd-complex. The aim this investigation was to compare GBCAs their potential trigger NSF. Forty-two healthy male rats received repeated intravenous injections six different at high doses simulate exposure seen patients severe renal dysfunction. Histopathological immunohistochemical analysis skin performed,...

Retrospective studies in patients with primary brain tumors or other central nervous system pathologies as well postmortem have suggested that gadolinium (Gd) deposition occurs the dentate nucleus (DN) and globus pallidus (GP) after multiple administrations of primarily linear Gd-based contrast agents (GBCAs). However, this has not been associated any adverse effects histopathological alterations. The aim preclinical study was to systematically examine differences between macrocyclic GBCAs...

In this prospective preclinical study, we evaluated T1-weighted signal intensity in the deep cerebellar nuclei (CN) and globus pallidus (GP) up to 24 days after repeated administration of linear macrocyclic gadolinium-based contrast agents (GBCAs) using homologous imaging evaluation methods as recently published retrospective clinical studies. a second part cerebrospinal fluid (CSF) spaces were for enhancement by fluid-attenuated magnetic resonance (MRI).

Signal hyperintensity on unenhanced MRI in certain brain regions has been reported after multiple administrations of some, but not all, gadolinium-based contrast agents (GBCAs). One potential initial pathway GBCA entry into the brain, infiltration from blood cerebrospinal fluid (CSF), was systematically evaluated this preclinical study. and distribution CSF were investigated healthy rats using repeated fluid-attenuated up to 4 h high-dose (1.8 mmol/kg) administration six marketed one...

Purpose To investigate the long-term course of MRI signal intensity (SI) changes and presence gadolinium in rat brain during a 1-year period after multiple administrations gadolinium-based contrast agents (GBCAs). Materials Methods Rats received linear GBCA (gadodiamide, gadopentetate dimeglumine, gadobenate dimeglumine), macrocyclic (gadobutrol, gadoterate meglumine, gadoteridol), or saline. Animals eight injections over 2 weeks (1.8 mmol/kg per injection). Brain measurements were performed...

To quantify differences in regional myocardial perfusion coronary artery stenosis by the use of dual source computed tomography (DSCT) an animal model.In 5 pigs, 80% left anterior descending was successfully induced partial balloon occlusion (ischemia group). Five animals served as control group. All underwent contrast enhanced whole heart DSCT (Definition Flash, Siemens, Germany) imaging using a prototype electrocardiogram -triggered dynamic scan mode. Imaging performed at rest well under...

Abstract Purpose To investigate the role of excess ligand present in gadolinium (Gd) ‐based contrast agents development nephrogenic systemic fibrosis (NSF). Using a dosing regimen to simulate exposure seen patients with severe renal impairment, we investigated effect on Gd‐deposition and depletion endogenous ions. Materials Methods Gadodiamide gadoversetamide were formulated 0%, 5%, 10% ligand. Forty‐two, healthy, male Hannover Wistar rats received daily intravenous injections each...

Very short acquisition times and the increasing use of low-kilovolt protocols in standard computed tomographic (CT) angiography (CTA) examinations demand modifications contrast media (CM) injection regimen. The aim this study was to optimize tube voltage-adjusted CM delivery parameters, especially duration iodine rate (IDR), thoracoabdominal CTA a porcine model.Eight pigs (53-72 kg) were examined with third-generation dual-source CT system dynamic protocol (4-dimensional spiral, 454-mm scan...

The glymphatic system is a recently hypothesized waste clearance of the brain in which perivascular space constitutes pathway similar to lymphatic other body regions. Sleep and anesthesia are reported influence activity system. Because rats nocturnal animals, expected be more active during day. We attempted elucidate for intravenously injected gadodiamide rat by 2 experiments. One was magnetic resonance imaging (MRI) experiment evaluate short-term dynamics signal intensity changes after...

The aim of this report was to characterize the key physicochemical, pharmacokinetic (PK), and magnetic resonance imaging (MRI) properties gadoquatrane (BAY 1747846), a newly designed tetrameric, macrocyclic, extracellular gadolinium-based contrast agent (GBCA) with high relaxivity stability.The r1-relaxivities tetrameric at 1.41 3.0 T were determined in human plasma nuclear relaxation dispersion profiles water plasma. complex stability analyzed serum over 21 days pH 7.4 37°C compared linear...

Abstract The mainstream magnetic iron oxide particles used as contrast media for resonance (MR) imaging are composed of a core surrounded by dextran or carboxydextran coat. size ranges from 2 nm to less than 10 nm, and the hydrodynamic diameter 20 about 120 nm. coat prevents aggregation sedimentation in aqueous solutions, achieves high biological tolerance, toxic side effects. Two kinds considered: (i) large (>30 nm), called superparamagnetic (SPIOs) liver imaging; (ii) smaller (<30...

Several publications have suggested a possible association between Gd-based contrast agents (GBCAs) and the development of nephrogenic systemic fibrosis, rare but serious disease. To date, fibrosis has been observed only in patients with severe renal insufficiency.The aim this study was to determine impact prolonged circulation time GBCAs caused by reduced clearance on long-term retention Gd skin rats after administration different GBCAs.Renally impaired Han Wistar Rats (5/6-nephrectomized...

Purpose The relaxivities of 3 macrocyclic gadolinium-based contrast agents (GBCAs) were determined in human plasma and blood under standardized clinically relevant laboratory conditions. Methods T 1 relaxivity, r1, was at 1.5, 3, 7 T, 37°C phantoms containing 4 different concentrations the GBCAs gadobutrol, gadoteridol, gadoterate. An inversion recovery turbo spin echo sequence used to generate images with several times. 1-times obtained by fitting signal intensities equation. r1 a...

Background: The low clinically approved doses of gadolinium-based contrast agents (GBCA) do not generate sufficient enhancement on CT for diagnostic purposes. Photon-counting detector (PCD) offers improved spectral resolution and could potentially enable visualization hepatocyte-specific GBCA given their associated high gadolinium concentrations within hepatocytes. Objective: To investigate the potential gadoxetate disodium in combination with PCD low-keV VMI reconstructions to achieve an...

Abstract Background Reducing radiation and contrast media (CM) doses in computed tomography angiography (CTA) is especially relevant for potentially vulnerable populations. Low tube voltage photon-counting detector CT (PCD-CT) offers an improved iodine contrast-to-noise ratio (CNR) as compared to conventional scanners. We investigated optimized CM of PCD-CT at low animal model. Methods Six minipigs (median weight: 32.5 kg; IQR: 29.8–34.6 kg) underwent thoracoabdominal CTA using a clinical...