A5090048519- Ultrasound Imaging and Elastography
- Elasticity and Material Modeling
- Liver Disease Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Infrared Thermography in Medicine
- Photoacoustic and Ultrasonic Imaging
- Inflammatory Bowel Disease
- Cardiovascular Health and Disease Prevention
- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Spine and Intervertebral Disc Pathology
- Microscopic Colitis
- Pancreatitis Pathology and Treatment
- Medical Image Segmentation Techniques
- Thermoelastic and Magnetoelastic Phenomena
- Blood properties and coagulation
- Viral gastroenteritis research and epidemiology
- Tendon Structure and Treatment
- Cancer Cells and Metastasis
- Ultrasound in Clinical Applications
- Medical Imaging and Analysis
- Scoliosis diagnosis and treatment
- Gout, Hyperuricemia, Uric Acid
- Lipid metabolism and disorders
Charité - Universitätsmedizin Berlin
2019-2024
Humboldt-Universität zu Berlin
2019-2023
Freie Universität Berlin
2019-2023
Patients with increased liver stiffness have a higher risk of developing cancer, however, the role fluid-solid tissue interactions and their contribution to tumor malignancy remains elusive. Tomoelastography is novel imaging method for mapping quantitatively solid-fluid properties soft tissues in vivo. It provides high resolution thus has clear clinical applications. In this work we used tomoelastography 77 participants, total 141 focal lesions different etiologies, investigate contributions...
Purpose Magnetic resonance elastography (MRE) maps the viscoelastic properties of soft tissues for diagnostic purposes. However, different MRE inversion methods yield results, which hinder comparison values, standardization, and establishment quantitative markers. Here, we introduce an expandable, open‐access, webserver‐based platform that offers multiple techniques multifrequency, 3D data. Methods The comprises a data repository standard including local frequency estimation (LFE),...
Purpose With abdominal magnetic resonance elastography (MRE) often suffering from breathing artifacts, it is recommended to perform MRE during breath‐hold. However, breath‐hold acquisition prohibits extended multifrequency examinations and yields inconsistent results when patients cannot hold their breath. The purpose of this work was analyze free‐breathing strategies in organs. Methods Abdominal with 30, 40, 50, 60 Hz vibration frequencies single‐shot, multislice, full wave‐field performed...
Mechanical properties of brain tissue are very complex and vary with the species, region, method, dynamic range, between in vivo ex measurements. To reconcile this variability, we investigated stiffness two distinct regions human mouse - hippocampus (HP) corpus callosum (CC) using different methods. Under quasi-static conditions, examined murine HP CC by atomic force microscopy (AFM). Between 16 40Hz, brains healthy volunteers magnetic resonance elastography (MRE) a 3-T clinical scanner. At...
Modulation of cerebral blood flow and vascular compliance plays an important role in the regulation intracranial pressure (ICP) also influences viscoelastic properties brain tissue. Therefore, magnetic resonance elastography (MRE), gold standard for measuring vivo viscoelasticity tissue, is potentially sensitive to autoregulation. In this study, we developed a multifrequency MMRE technique that provides serial maps at frame rate nearly 6 Hz without gating, i.e., quasi-real time (rt-MMRE)....
Estimations of tumor volume and boundary in pancreatic ductal adenocarcinoma (PDAC) are crucial for surgery planning. The aim the study is to evaluate tomoelastography detection PDAC quantification based on tissue stiffness.From March 2018 December 2019, a total 102 participants (30 healthy 72 patients with histologically proven PDAC) were prospectively enrolled multicenter study. Multifrequency magnetic resonance elastography was combined postprocessing generate maps shear wave speed (SWS)...
Biomechanical changes are critical for cancer progression. However, the relationship between rheology of single cells measured ex-vivo and living tumor is not yet understood. Here, we combined single-cell isolated from primary tumors with
The liver is the central metabolic organ. It constantly adapts its capacity to current physiological requirements. However, relationship between tissue structure and hepatic function incompletely understood; this results in a lack of diagnostic markers medical imaging that can provide information about liver's capacity. Therefore, using normal rabbit livers, we combined magnetic resonance elastography (MRE) with proteomics-based kinetic modeling metabolism investigate potential role MRE for...
Time-harmonic elastography (THE) is an emerging ultrasound imaging technique that allows full-field mapping of the stiffness deep biological tissues. THE's unique ability to rapidly capture in multiple tissues has never been applied for skeletal muscle. Therefore, we addressed lack data on temporal changes muscle while simultaneously covering different muscles. Acquiring repeated THE scans every five seconds quantified shear-wave speed (SWS) as a marker long head (LHB) and short (SHB) biceps...
Abstract Spatial heterogeneity of hepatic fibrosis in primary sclerosing cholangitis (PSC) comparison to viral hepatitis was assessed as a potential new biomarker using MR elastography (MRE). In this proof-of-concept study, we hypothesized rather increased PSC and homogeneous distribution hepatitis. Forty-six consecutive subjects (PSC: n = 20, hepatitis: 26) were prospectively enrolled between July 2014 April 2017. Subjects underwent multifrequency MRE (1.5 T) drive frequencies 35–60 Hz...
A method for measuring intracranial pressure (ICP) noninvasively has long been sought after in neurology and neurosurgery. Treatment failure individuals presenting with unspecific symptoms such as headache, gait disturbance, or visual impairment occurring response to increased ICP can lead irreversible brain injury, progressive disability, death. Guidelines diagnostic measurement recommend placement of tip catheters lumbar puncture (LP) despite their invasiveness possible complications. As...
Purpose: Magnetic resonance elastography (MRE) generates quantitative maps of the mechanical properties biological soft tissues. However, published values obtained by brain MRE vary largely and lack detail resolution, due to either true effects or technical challenges. We here introduce cerebral tomoelastography in two three dimensions for improved data consistency resolution while considering aging, parenchymal fraction (BPF), systolic blood pressure, body mass index (BMI). Methods:...
Although there is growing evidence that functional involvement and structural changes of mesenteric adipose tissue (MAT) influence the course Crohn's disease (CD), its viscoelastic properties remain elusive. Therefore, we aimed to investigate MAT in CD using magnetic resonance elastography (MRE), providing reference values for diagnosis.In this prospective proof-of-concept study, 31 subjects (CD: n=11; healthy controls: n=20) were consecutively enrolled a specialized care center inflammatory...
Depicting the stiffness of biological soft tissues, MR elastography (MRE) has a wide range diagnostic applications. The purpose this study was to improve temporal resolution 2D hepatic MRE in order provide more rapid feedback on quality wavefield and ensure better sampling respiration-induced changes.We developed sequence that uses segmented gradient-echo spiral readout encode 40 Hz harmonic vibrations generate maps within 625 ms. We demonstrate use technique as test for shear wave...
To study the potential of viscoelastic parameters such as liver stiffness, loss tangent (marker viscous properties) and dispersion to detect hepatic inflammation by in-vivo ex-vivo MR elastography (MRE) at low high vibration frequencies.
Hydration influences blood volume, viscosity, and water content in soft tissues – variables that determine the biophysical properties of biological including their stiffness. In brain, relationship between hydration stiffness is largely unknown despite increasing importance as a quantitative imaging marker. this study, we investigated cerebral (CS) 12 healthy volunteers using ultrasound time-harmonic elastography (THE) different states: (i) during normal hydration, (ii) after overnight...
Purpose In vivo MR elastography (MRE) holds promise as a neuroimaging marker. cerebral MRE, shear waves are introduced into the brain, which also stimulate vibrations in adjacent CSF, resulting blurring and biased stiffness values near brain surfaces. We here propose inversion‐recovery MRE (IR‐MRE) to suppress CSF signal improve quantification surface areas. Methods Inversion‐recovery was demonstrated agar‐based phantoms with solid‐fluid interfaces 11 healthy volunteers using 31.25‐Hz...
Despite the success in detecting intervertebral disc degeneration with high-resolution T2 sequences, conventional MRI is limited by large inter-reader variability as well lacking stratification of clinical trials and their assessment treatment responses. Several studies have shown technical feasibility MR elastography for study disc, but its relevance remains unclear. This shows an excellent diagnostic performance multifrequency evaluation lumbar spine degeneration.
Despite increasing evidence that the functional involvement and structural changes of mesenteric adipose tissue influence course Crohn's disease, its viscoelastic properties remain elusive. We demonstrate feasibility in vivo MR elastography present preliminary reference values for disease patients healthy controls this explorative study. Our results show an excellent diagnostic performance detecting by assessing using histopathology surgical specimens as reference. motivate further studies...
Multiple sclerosis (MS) is a chronic neuroinflammatory disease that affects both white matter and cortical areas. While magnetic resonance imaging (MRI) can image pathological changes in the matter, it limited quantifying tissue damage MS. Therefore, cerebral 3D-MR elastography based on multifrequency wave excitation tomoelastography postprocessing was developed to measure stiffness. We found cortex MS patients markedly softer than global brain deep gray indicating use of as potential new...
Motivation: The relationship between the microstructural changes and imaging-based biophysical properties of liver as NASH progresses are not fully established. Goal(s): We aim to identify quantitative imaging markers that can provide valuable insights into progression NASH. Approach: established non-alcoholic steatohepatitis in mice with a defined amino-acid high-fat diet. performed MRI, MR elastography histological scoring automated fat segmentation at different times during course...