A5082116571- Breast Cancer Treatment Studies
- Economic and Financial Impacts of Cancer
- Cancer survivorship and care
- Clinical practice guidelines implementation
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Global Cancer Incidence and Screening
- Gastric Cancer Management and Outcomes
- Health and Medical Studies
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Screening and Detection
- Endometrial and Cervical Cancer Treatments
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Colorectal and Anal Carcinomas
- Palliative Care and End-of-Life Issues
- Lung Cancer Treatments and Mutations
- Estrogen and related hormone effects
- Breast Lesions and Carcinomas
- BRCA gene mutations in cancer
University of Regensburg
2016-2025
German Cancer Society
2018-2025
University Hospital Regensburg
2007-2024
Deutsche Forschungsgemeinschaft
2024
Deutsches Forschungsnetz
2020-2023
Health and Safety Authority
2023
Fischer (Germany)
2016-2019
Klinikum Sindelfingen-Böblingen
2015
University of Göttingen
2009
National Cancer Registry
2006
The proliferation marker Ki-67 is one of the most controversially discussed parameters for treatment decisions in breast cancer patients. purpose this study was to evaluate routine use and value as a prognostic marker, analyze associations between common histopathological clinical setting. Data from registry Regensburg (Bavaria, Germany) were analyzed. Within total data pool 4,692 female patients, who had been diagnosed 2005 2011, 3,658 cases routinely determined. Thus, patients with...
Purpose of this study was to analyse the surgical management and long-term clinical outcome patients diagnosed with colorectal liver metastases (CLM) over a period 10 years using data from German tumour registry.Retrospective analysis 5772 adenocarcinoma between 2002 2007. Follow-up continued until 2012.1426 (24.7%) had CLM; 1019 (71%) synchronous, 407 (29%) developed metachronous CLM. Hepatic resection performed in 374 1426 CLM (26%). A significant increase rate 16.6% for cohort 32% later...
According to the National Cancer Plan in Germany, all cancer patients should receive high-quality care accordance with evidence-based treatment guidelines. Certification programs were established for this purpose but have not yet been comprehensively evaluated.
Abstract Background Certified cancer centers aim to ensure high-quality care by establishing structural and procedural standards according evidence-based guidelines. Despite the high clinical health policy relevance, evidence from a nation-wide study for effectiveness of colorectal in certified vs. other hospitals Germany is still missing. Methods In retrospective cohort covering years 2009–2017, we analyzed patient data using demographic information, diagnoses, treatments nationwide...
The aim of the present study was to identify human genes that might prove useful in diagnosis and therapy primary breast cancer.Twenty-four matched pairs invasive ductal cancer corresponding benign tissue were investigated by a combination laser microdissection gene expression profiling. Differential candidate validated dot blot analysis cDNA 50 matching malignant tissue. Cellular further RNA situ hybridization, quantitative reverse transcription-PCR, immunohistochemistry using microarray...
The prevalence and development of microsatellite instability (MSI) underlying mismatch repair (MMR) deficiency in the carcinogenesis adenocarcinomas papilla Vater their precursor lesions are not well established. We analyzed 120 ampullary adenomas (31 pure 89 carcinoma-associated adenomas) 170 for MSI, immunohistochemical expression MMR proteins specific histopathologic features. most common histologic subtype was intestinal (46.5%), followed by pancreatobiliary (23.5%), poorly...
Despite thousands of papers, the value quality life (QoL) in curing disease remains uncertain. Until now, we lacked tools for diagnosis and specific treatment diseased QoL. We approached this problem stepwise by theory building, modelling, an exploratory trial now a definitive randomised controlled (RCT) breast cancer, whose results report here. In all, 200 representative Bavarian primary cancer patients were recruited five hospitals treated 146 care professionals. Patients to either (1)...
Abstract Introduction Colorectal carcinomas represent the third most common cause of cancer-related deaths in Germany. Although incidence is significantly higher men compared with women and gender a well-established crucial factor for outcome other diseases, detailed comparisons colon cancer are lacking. Methods This retrospective population-based cohort study included all patients diagnosed Germany between 2000 2016 who were dataset colorectal from quality conference German Cancer Society....
High‐grade glioma (HGG) is associated with poor prognosis. Drug repurposing evolves as new modality to improve standard therapy. The antidiabetic drug metformin has been found inhibit cell growth in vitro and vivo . aim of the present retrospective cohort study was evaluate survival patients HGG or without treatment metformin, based on a large cancer registry. analysis included 1,093 diagnosed between 1998 2013 from population‐based clinical registry Regensburg (Germany), which covers 2.1...
Abstract Background Treatment of cancer patients in certified centers, that meet specific quality standards term structures and procedures medical care, is a national treatment goal Germany. However, convincing evidence centers associated with better outcomes pancreatic still missing. Methods We used patient-specific information (demographic characteristics, diagnoses, treatments) from German statutory health insurance data covering the period 2009–2017 hospital characteristics Standardized...
Abstract Purpose The aim of our study was to explore the impact COVID-19 pandemic on reported cancer cases in Bavaria, Germany, by comparing pre-pandemic (March 2019 February 2020) and period 2020 2021). Methods Data incident were retrieved from Bavarian Cancer Registry (until 22nd April 2022). We included patients with malignant situ neoplasms pathology departments consistent reporting. calculated number during 95% confidence intervals (CI) Bonferroni correction (α = 0.0018) based a Poisson...
Background: Metastases of renal cell carcinoma (RCC) to the thyroid gland are uncommon. There is no clear consensus regarding role surgery in metastatic disease since most clinical studies include small numbers patients. Also, risk factors associated with progression following thyroidectomy not yet defined. We examined determinants outcome patients undergoing for metastases RCC. Methods: The medical records 45 resection RCC at 15 institutions Germany and Austria were reviewed...
On July 1, 2009, the German Network for Health Services Research [Deutsches Netzwerk Versorgungsforschung e. V. (DNVF V.)] approved Memorandum III "Methods Research", supported by member societies mentioned as authors and published in this Journal [Gesundheitswesen 2009; 71: 505-510]. This is an in-depth publication on "quality-of-life assessment health services research". Within context of sciences, quality life (QL) encompasses subjective well-being functioning physical, psychological...
The aim of the present study was to evaluate what extent combination standard histopathological parameters determines biology breast cancer and effect on therapy prognosis. Clinical Cancer Registry Regensburg (Bavaria, Germany) included n = 4,480 female patients with primary, non-metastatic (M0) invasive diagnosed between 2000 2012. Immuno-histochemical analyses, i.e., estrogen receptor (ER), progesterone (PR), HER2, Ki-67 (4-IHC), defined tumor biological subtypes Luminal A, B, HER2-like,...
Currently, the use of radioisotope and blue dye for sentinel lymph node biopsy (SLNB) axillary staging in breast cancer is common. Recently, indocyanine green (ICG) has been proposed as an alternative (SLN) tracking agent. We evaluated clinical value ICG additional tracer combination with Technetium99m to identification SLN 104 patients. 21 patients had at least 1 histologically tumor-positive SLN. All were detected by ICG; one these sentinel-positive patients, was unable identify...
The clinicopathological significance of the mucinous subtype colorectal cancer (CRC) remains controversial. As today, none current guidelines differentiate treatment with respect to or nonmucinous cancer. Due lack substantiated data, best unclear and CRC is usually treated along lines recommendations for adenocarcinoma colon.We investigated an East-Bavarian cohort 8,758 patients CRC. These included 613 (7.0%) a subtype, who were analyzed assessing their characteristics in clinical course...
5-Fluorouracil (5FU), Folinic acid (FA), and Oxaliplatin (FOLFOX) or 5FU, FA, Irinotecan (FOLFIRI) are standard regimens for palliative chemotherapy of metastatic colon cancer. Since data showing the influence dose reduction in treatment rare, objective this single center, retrospective study was to further characterize on efficacy these therapeutic regimens.One hundred nine patients, diagnosed with stage IV cancer between 2004 2012 receiving first-line either FOLFOX FOLFIRI our outpatient...
Abstract Background Rectal cancer is frequent in Germany and worldwide. Several studies have assessed laparoscopic surgery as a treatment option most shown favorable results. However, long-term oncologic safety remains controversial issue. Methods The current dataset derives from 30 clinical registries includes 16,378 patients diagnosed with rectal between 2007 2016. Outcomes were 90-day mortality, overall survival (OS), local recurrence-free (RFS) relative of treated either open or surgery....
Abstract Certified breast cancer centers offer specific quality standards in terms of their structure, diagnostic and treatment approaches with regards to surgery, drug-based therapy, radiotherapy, psychosocial support. Such aim improve outcomes patients. The question investigated here was whether patients primary have a longer overall survival if they are treated certified center compared outside these centers. We used patient-specific data (demographics, diagnoses, treatments) obtained...
Abstract Purpose The optimal time to initiation of adjuvant chemotherapy (TTAC) for triple negative breast cancer (TNBC) patients is unclear. This study evaluates the association between TTAC and survival in TNBC patients. Methods We conducted a retrospective using data from cohort diagnosed January 1, 2010 December 31, 2018, registered Tumor Centre Regensburg was conducted. Data included demographics, pathology, treatment, recurrence survival. defined as days primary surgery first dose...
Correction to: Endometrial Cancer – Long-Term Survival in Certified Centers and Non-Certified HospitalsGeburtshilfe Frauenheilkd 2024; 84(10): 979-988DOI: 10.1055/a-1869-2060