A5056928195- Heart Failure Treatment and Management
- Acute Kidney Injury Research
- Renal and related cancers
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Renal and Vascular Pathologies
- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Single-cell and spatial transcriptomics
- Pituitary Gland Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Dialysis and Renal Disease Management
- Potassium and Related Disorders
- Erythropoietin and Anemia Treatment
- Neuroendocrine Tumor Research Advances
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Acute Myeloid Leukemia Research
- Cancer therapeutics and mechanisms
- Health, Environment, Cognitive Aging
- Lung Cancer Research Studies
- Chronic Disease Management Strategies
- Clostridium difficile and Clostridium perfringens research
- Immune Response and Inflammation
- Chronic Myeloid Leukemia Treatments
University of Southern California
2021-2024
University Medical Centre Mannheim
2023-2024
Broad Center
2021-2024
Heidelberg University
2023-2024
University Hospital Heidelberg
2023-2024
Harvard University
2013-2023
Massachusetts General Hospital
2013-2023
Keck Hospital of USC
2023
Kantonsspital Aarau
2019-2020
Center for Systems Biology
2013-2016
Healing after myocardial infarction involves the biphasic accumulation of inflammatory lymphocyte antigen 6C (Ly-6C)(high) and reparative Ly-6C(low) monocytes/macrophages (Mo/MΦ). According to 1 model, Mo/MΦ heterogeneity in heart originates blood sequential recruitment distinct monocyte subsets that differentiate macrophages. Alternatively, may arise tissue from circulating subset via local macrophage differentiation polarization. The orphan nuclear hormone receptor, receptor subfamily 4,...
Significance A single acute kidney injury event increases the risk of progression to chronic disease (CKD). Combining single-nucleus RNA sequencing with genetic tracing injured proximal tubule cells identified a spatially dynamic, evolving response following ischemia–reperfusion injury. Failed repair leads persistence profibrotic, proinflammatory Vcam1 + / Ccl2 cell type exhibiting senescence-associated secretory phenotype and marked transcriptional activation NF-κB AP-1 pathway signatures,...
Significance Statement Understanding the mechanisms underlying adaptive and maladaptive renal repair after AKI their long-term consequences is critical to kidney health. The authors used lineage tracing of cycling cells single-nucleus multiomics (profiling transcriptome chromatin accessibility) AKI. They demonstrated that triggers a cell-cycle response in most epithelial nonepithelial cell types. also showed proinflammatory proximal tubule (PTCs) persist until 6 months post-AKI, although...
Pneumonia is a major cause of mortality worldwide and serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show response to lung infection, B1a B cells migrate from pleural space parenchyma secrete polyreactive emergency immunoglobulin M (IgM). The process requires innate activator (IRA) cells, transitional B1a-derived inflammatory subset which controls IgM production via autocrine...
Atherosclerotic lesions grow via the accumulation of leukocytes and oxidized lipoproteins in vessel wall. Leukocytes can attenuate or augment atherosclerosis through release cytokines, chemokines, other mediators. Deciphering how develop, oppose, complement each other's function shape course disease illuminate our understanding atherosclerosis. Innate response activator (IRA) B cells are a recently described population granulocyte macrophage colony-stimulating factor-secreting hitherto...
Sodium-glucose co-transporter-2 (SGLT2) inhibitors improve clinical outcomes in patients with heart failure (HF), but mechanisms of action are incompletely understood. In the EMPA-TROPISM trial, empagliflozin reversed cardiac remodeling and increased physical capacity stable non-diabetic systolic HF. Here we explore, post hoc, whether treatment effects this cohort, comprising who had a high prevalence iron deficiency, were related to metabolism. Myocardial content estimated by magnetic...
Multimorbidity (two or more comorbidities) is common among patients with acute heart failure, but comprehensive global information on its prevalence and clinical consequences across different world regions income levels scarce. This study aimed to investigate the of multimorbidity effect pharmacotherapy prognosis in participants REPORT-HF study.REPORT-HF was a prospective, multicentre, cohort that enrolled adults (aged ≥18 years) admitted hospital primary diagnosis failure from 358 hospitals...
Macrophages in the arterial intima sustain chronic inflammation during atherogenesis. Under hypercholesterolemic conditions murine Ly6Chigh monocytes surge blood and spleen, infiltrate nascent atherosclerotic plaques, differentiate into macrophages that proliferate locally as disease progresses. Spleen tyrosine kinase (SYK) may participate downstream signaling of various receptors mediate these processes. We tested effect SYK inhibitor fostamatinib on hypercholesterolemia-associated...
Kidney injury disrupts the intricate renal architecture and triggers limited regeneration, injury-invoked inflammation fibrosis. Deciphering molecular pathways cellular interactions driving these processes is challenging due to complex architecture. Here, we applied single cell spatial transcriptomics examine ischemia-reperfusion in mouse kidney. Spatial revealed injury-specific spatially-dependent gene expression patterns distinct microenvironments within kidney predicted
PURPOSE In this phase II and pharmacokinetic study, chronic, low-dose, oral etoposide was evaluated for its efficacy in patients with AIDS-related Kaposi's sarcoma who were not previously exposed to cytotoxic therapy. PATIENTS AND METHODS Of 28 accrued the 25 assessable toxicity response. Twenty-four male (homosexual or bisexual cases) one patient female (partner of a male). All human immunodeficiency virus (HIV)-positive, New York University (NYU) disease stage IIB IVB, most exhibiting skin...
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) impact iron metabolism in patients with heart failure but mechanisms are incompletely understood. This post hoc analysis explored interrelations between homeostasis, cardiac structure/function, exercise capacity, haematopoiesis, and sympathetic activity at baseline, the effects of 6-month treatment empagliflozin vs. placebo by anaemia status EMPATROPISM-FE study participants. Myocardial content (MIC, estimated magnetic resonance T2*...
Abstract Background The importance of chronic kidney disease (CKD) and anaemia has not been comprehensively studied in asymptomatic patients at risk for heart failure (HF) versus those with symptomatic HF. We analysed the prevalence, characteristics prognostic impact both conditions across American College Cardiology/American Heart Association (ACC/AHA) precursor HF stages A–D. Methods results 2496 participants from three non-pharmacological German Competence Network studies were categorized...
Fifth Department of Medicine, Faculty Medicine Mannheim the University Heidelberg, Medical Center Mannheim, Germany Correspondence: Dr. Louisa M.S. Gerhardt, email: [email protected] See related article, "Spatiotemporal Landscape Kidney Tubular Responses to Glomerular Proteinuria," on pages XXX–XXX.
Background: Grafts, which allow early cannulation have been increasingly used to avoid starting dialysis via tunneled hemodialysis catheters. As we noted graft failures in patients with grafts, reviewed the outcome of these grafts and compared it ePTFE grafts. Materials Methods: We retrospectively analyzed time first intervention, primary secondary patency rates as well number interventions needed maintain who received an (GORE ® ACUSEAL, acuseal) or (GORE-TEX ) vascular between January 2016...
Abstract Background: Paraneoplastic Cushing’s syndrome is a rare cause of hypercortisolism associated with high morbidity, especially in patients small cell lung cancer. Therefore, early diagnosis and treatment are critical. Clinical Case: Herein we present the case 58-year-old man who was referred to endocrinology department, because refractory hypokalemia (potassium 2.4 mmol/l; RI: 3.4 - 4.5 mmol/l) despite potassium supplements spironolactone therapy. History remarkable for metabolic...
Zusammenfassung Anamnese und klinischer Befund Ein 58-jähriger Mann stellte sich mit therapierefraktärer Hypokaliämie rascher Gewichtszunahme vor. Klinisch bestanden hypertensive Blutdruckwerte, eine stammbetonte Adipositas ausgeprägte Beinödeme. Untersuchungen Diagnose Die Laboruntersuchungen ergaben hypokaliämische metabolische Alkalose bei ACTH-abhängigem Hyperkortisolismus. Thorax-Abdomen-CT zeigte pulmonale Raumforderung der rechten Nebenniere. Bioptisch wurde die eines...
Abstract Sodium-glucose cotransporter-2 (SGLT2) inhibitors improve clinical outcomes in patients with heart failure (HF), but mechanisms of action are incompletely understood. In the EMPATROPISM trial, empagliflozin reversed cardiac remodeling and increased physical capacity stable non-diabetic systolic HF. EMPATROPISM-FE explored post hoc this cohort, who had a high prevalence iron deficiency, whether treatment effects were related to changes metabolism. Here we show that myocardial content...