A5038714711- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Immune cells in cancer
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Respiratory Support and Mechanisms
- Liver Disease and Transplantation
- Cardiac pacing and defibrillation studies
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Cardiovascular Function and Risk Factors
- Xenotransplantation and immune response
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular and Diving-Related Complications
- T-cell and B-cell Immunology
- Organ Transplantation Techniques and Outcomes
- Hematopoietic Stem Cell Transplantation
- Liver Disease Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mechanical Circulatory Support Devices
- Trauma Management and Diagnosis
- Hemodynamic Monitoring and Therapy
- Atrial Fibrillation Management and Outcomes
- Virus-based gene therapy research
- Frailty in Older Adults
Massachusetts General Hospital
2017-2024
Harvard University
2018-2024
Broad Institute
2021-2023
Massachusetts Institute of Technology
2023
The Royal Melbourne Hospital
2020
Mayo Clinic
2020
American Society of Anesthesiologists
2015-2019
Cleveland Clinic
2012-2019
University of Iowa
2016
Outcomes Research Consortium
2014-2015
Bacterial sepsis and severe COVID-19 share similar clinical manifestations are both associated with dysregulation of the myeloid cell compartment. We previously reported an expanded CD14
Mechanisms of neutrophil involvement in severe coronavirus disease 2019 (COVID-19) remain incompletely understood. Here, we collect longitudinal blood samples from 306 hospitalized COVID-19+ patients and 86 controls perform bulk RNA sequencing enriched neutrophils, plasma proteomics, high-throughput antibody profiling to investigate relationships between states severity. We identify dynamic switches six distinct subtypes. At days 3 7 post-hospitalization, with display a granulocytic...
Limited data exist regarding ventilation in patients with class III obesity [body mass index (BMI) > 40 kg/m2] and acute respiratory distress syndrome (ARDS). The aim of the present study was to determine whether an individualized titration mechanical according cardiopulmonary physiology reduces mortality ARDS.In this retrospective study, we enrolled adults admitted ICU from 2012 2017 who had ARDS received for 48 h. Enrolled were divided two cohorts: one cohort (2012-2014) ventilator...
Cirrhotic cardiomyopathy causes variable degree of systolic and diastolic dysfunction (DD) conduction abnormalities. The primary aim our study was to determine whether pre-transplant DD prolonged corrected QT (QTc) predict a composite mortality, graft failure, major cardiovascular events after liver transplantation. We also evaluated the reversibility cirrhotic Adult patients who underwent transplantation at institution from January 2007 March 2009 were included. Data obtained institutional...
Rationale: Obesity is characterized by elevated pleural pressure (Ppl) and worsening atelectasis during mechanical ventilation in patients with acute respiratory distress syndrome (ARDS).Objectives: To determine the effects of a lung recruitment maneuver (LRM) presence Ppl on hemodynamics, left right ventricular pressure, pulmonary vascular resistance. We hypothesized that protects cardiovascular system against high airway prevents overdistension.Methods: First, an interventional crossover...
Abstract With the increasing age of recipients undergoing orthotopic liver transplant ( OLT ), there is need for better risk stratification among them. Our study aims to identify predictors poor outcome ≥60 yr age. All patients who underwent at Cleveland Clinic from January 2004 April 2010 were included. Baseline patient characteristics and post‐ outcomes (mortality, graft failure, length stay, major cardiovascular events) obtained prospectively collected institutional registry. Among age,...
The immediate effect of aortic valve replacement (AVR) for stenosis on perioperative myocardial function is unclear. Left ventricular (LV) may be impaired by cardioplegia-induced arrest and ischemia-reperfusion injury, especially in patients with LV hypertrophy. Alternatively, improve when afterload reduced after AVR. right ventricle (RV), however, experiences cardioplegic without benefiting from improved loading conditions. Which these effects dominate undergoing AVR has not been thoroughly...
Abstract Although most patients presenting for liver transplantation have normal left ventricular function, some develop failure after transplantation. The primary objective of our study was to determine the predictors systolic heart (HF) occurring immediately Its etiology, prospects recovery, and factors associated with nonrecovery were also studied. Liver transplantations performed at institution from January 2006 February 2015 evaluated using prospectively collected institutional...
Introduction. Attempts to achieve immunological tolerance porcine tissues in nonhuman primates through establishment of mixed hematopoietic chimerism are hindered by the rapid clearance mobilized leukocytes, containing progenitor cells (pPBPCs), from circulation. Eighteen hours after infusing 1–2×1010 pPBPC/kg into baboons that had been depleted circulating anti-αGal and complement, these almost undetectable flow cytometry. The aim present study was identify mechanisms contribute pPBPCs...
Abstract: Anti‐Galα1–3Gal antibodies (antiαGal Ab) are a major barrier to clinical xenotransplantation as they believed initiate both hyperacute and acute humoral rejection. Extracorporeal immunoadsorption (EIA) with αGal oligosaccharide columns temporarily depletes antiαGal Ab, but their return is ultimately associated graft destruction. We therefore assessed the ability of two immunotoxins (IT) monoclonal (mAb) deplete B and/or plasma cells in vitro vivo baboons, observe rate Ab following...
Frailty is associated with adverse postoperative outcomes, but it remains unclear which measure of frailty best. This study compared two approaches: the Modified Index, a deficit accumulation model (number accumulated deficits), and Hopkins Score, phenotype (consisting shrinking, weakness, exhaustion, slowness, low physical activity). The primary aim was to compare ability each score predict prolonged hospitalization. Secondarily, 30-day readmission and/or complications compared.This...
<h3>BACKGROUND:</h3> Beneficial effects of breathing at F<sub>IO<sub>2</sub></sub> < 0.21 on disease outcomes have been reported in previous preclinical and clinical studies. However, the safety intra-hospital feasibility hypoxic gas for 5 d not established. In this study, we examined physiologic a mixture with as low 0.11 healthy volunteers. <h3>METHODS:</h3> All subjects completed spending consecutive days tent, where ambient oxygen level was lowered stepwise manner over d, from 0.16...
Abstract A recent estimate suggests that one in five deaths globally are associated with sepsis 1 . To date, no targeted treatment is available for this syndrome, likely due to substantial patient heterogeneity 2,3 and our lack of insight into immunopathology 4 These issues highlighted by the current COVID-19 pandemic, wherein many clinical manifestations severe SARS-CoV-2 infection parallel bacterial 5–8 We previously reported an expanded CD14+ monocyte state, MS1, patients or...
Whether carotid artery stenosis predicts stroke after noncardiac surgery remains unknown. We therefore tested the primary hypothesis that degree of is associated with in-hospital or 30-day all-cause mortality surgery. As also a marker for cardiovascular disease, our secondary was postoperative myocardial injury.We included adults who had noncardiac, noncarotid at Cleveland Clinic from 2007 to 2011 and duplex ultrasound performed either within 6 months before 1 month Internal peak systolic...
Left ventricular ejection fraction (LVEF) is often preserved in patients with aortic stenosis and thus cannot distinguish between normal myocardial contractile function subclinical dysfunction. Global longitudinal strain rate (SR), which measure deformation, are robust indicators of can detect subtle dysfunction that not apparent conventional echocardiographic measures. Strain SR may better predict postoperative outcomes than LVEF. The primary aim our investigation was to assess the...
Abstract Resident macrophages and infiltrating monocytes in kidneys of patients with lupus nephritis are altered both frequency function relative to their counterparts healthy kidneys. The extent which mouse models might be useful developing approaches target these cells for treating is poorly understood. Here, we studied four common that share clinical, serologic, histopathologic kidney changes humans. Using single-cell profiling multiplex spatial imaging analyze the intrarenal myeloid...
Abstract: Establishment of mixed bone marrow chimerism has been used to induce tolerance solid organ transplants in several allograft and xenograft models. The species specificity displayed by some important hematopoietic cytokines potentially limits the efficacy this approach pig‐to‐primate In order examine role porcine‐specific factors may play establishment xenogeneic chimerism, we have cloned heterologously expressed genes encoding porcine IL‐3 granulocyte‐macrophage colony‐stimulating...