A5101707784- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Neonatal Respiratory Health Research
- Intensive Care Unit Cognitive Disorders
- Electrical and Bioimpedance Tomography
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hemodynamic Monitoring and Therapy
- Thermal Regulation in Medicine
- Mechanical Circulatory Support Devices
- Airway Management and Intubation Techniques
- Ultrasound in Clinical Applications
- Inhalation and Respiratory Drug Delivery
- Thyroid Cancer Diagnosis and Treatment
- Solar Energy Systems and Technologies
- Cardiac Arrhythmias and Treatments
- Structural Engineering and Vibration Analysis
- Advanced X-ray and CT Imaging
- Effects of Environmental Stressors on Livestock
- Material Selection and Properties
- Wind and Air Flow Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmacological Effects and Assays
- Linguistics and Education Research
- Maternal and Neonatal Healthcare
- Cardiac Ischemia and Reperfusion
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
1997-2024
American Thoracic Society
2024
Instituto do Coração
2024
Universidade Cruzeiro do Sul
2024
Universidade de São Paulo
1995-2018
Universidade Brasil
2016
Hamilton Medical (Switzerland)
2012
In normal lungs, local changes in pleural pressure (P(pl)) are generalized over the whole surface. However, a patient with injured we observed (using electrical impedance tomography) pendelluft phenomenon (movement of air within lung from nondependent to dependent regions without change tidal volume) that was caused by spontaneous breathing during mechanical ventilation.To test hypotheses lungs negative P(pl) generated diaphragm contraction has localized effects (in regions) not uniformly...
Rationale: Esophageal manometry is the clinically available method to estimate pleural pressure, thus enabling calculation of transpulmonary pressure (Pl). However, many concerns make it uncertain in which lung region esophageal reflects local Pl.Objectives: To determine accuracy (Pes) and regions (Ppl) Pl; assess whether stress nondependent can be estimated at end-inspiration from Pl.Methods: In lung-injured pigs (n = 6) human cadavers 3), Pes was measured across a range positive...
In acute respiratory distress syndrome (ARDS), atelectatic solid-like lung tissue impairs transmission of negative swings in pleural pressure (Ppl) that result from diaphragmatic contraction. The localization more Ppl proportionally increases dependent stretch by drawing gas either other regions (e.g., nondependent [pendelluft]) or the ventilator. Lowering level spontaneous effort and/or converting to fluid-like might render noninjurious.To determine whether injury, and such injury would be...
Objectives: Pneumothorax is a frequent complication during mechanical ventilation. Electrical impedance tomography (EIT) noninvasive tool that allows real-time imaging of regional The purpose this study was to 1) identify characteristic changes in the EIT signals associated with pneumothoraces; 2) develop and fine-tune an algorithm for their automatic detection; 3) prospectively evaluate its sensitivity specificity detecting pneumothoraces real time. Design: Prospective controlled laboratory...
Objectives: We recently described how spontaneous effort during mechanical ventilation can cause “pendelluft,” that is, displacement of gas from nondependent (more recruited) lung to dependent (less early inspiration. Such transfer depends on the coexistence more recruited (source) liquid-like regions together with less (target) solid-like regions. Pendelluft may improve exchange, but because tidal recruitment, it also contribute injury. hypothesize higher positive end-expiratory pressure...
Rationale: Spontaneous breathing during mechanical ventilation increases transpulmonary pressure and Vt, worsens lung injury. Intuitively, controlling Vt might limit injury caused by added spontaneous effort.Objectives: To test the hypothesis that, effort in injured lungs, limitation of volume-controlled results less injurious patterns inflation.Methods: Dynamic computed tomography was used to determine regional inflation rabbits with lungs or pressure-controlled ventilation. Transpulmonary...
Atelectasis develops in critically ill obese patients when undergoing mechanical ventilation due to increased pleural pressure. The current study aimed determine the relationship between transpulmonary pressure, lung mechanics, and morphology quantify benefits of a decremental positive end-expiratory pressure trial preceded by recruitment maneuver.Prospective, crossover, nonrandomized interventional study.Medical Surgical Intensive Care Units at Massachusetts General Hospital (Boston, MA)...
Rationale: Obesity is characterized by elevated pleural pressure (Ppl) and worsening atelectasis during mechanical ventilation in patients with acute respiratory distress syndrome (ARDS).Objectives: To determine the effects of a lung recruitment maneuver (LRM) presence Ppl on hemodynamics, left right ventricular pressure, pulmonary vascular resistance. We hypothesized that protects cardiovascular system against high airway prevents overdistension.Methods: First, an interventional crossover...
Abstract Background Bronchoscopic lung volume reduction (BLVR) with one-way endobronchial valves (EBV) has better outcomes when the target lobe poor collateral ventilation, resulting in complete atelectasis. High-inspired oxygen fraction (F I O 2 ) promotes atelectasis through faster gas absorption after airway occlusion, but its application during BLVR EBV been poorly understood. We aimed to investigate real-time effects of F on regional volumes and ventilation/perfusion by electrical...
A febre sem sinais localizatórios (FSSL) em crianças representa um desafio diagnóstico significativo, com causas diversas, como infecções, doenças inflamatórias, reumatológicas, neoplásicas e até de origem central. abordagem clínica requer protocolos específicos para evitar diagnósticos equivocados tratamentos desnecessários. Esta revisão narrativa analisou artigos 2018 a 2024, buscando estratégias diagnósticas manejo FSSL. pesquisa foi realizada nas bases PubMed, MedLine LILACS, foco...
Acute respiratory distress syndrome (ARDS) patients may present impaired in lung function and structure after hospital discharge that be related to mechanical ventilation strategy. The aim of this study was evaluate the association between functional structural impairment, N-terminal-peptide type III procollagen (NT-PCP-III) driving pressure during protective ventilation. It a secondary analysis data from randomized controlled trial included with moderate/severe ARDS at least one follow-up...
Lower fractional inspired oxygen tension (Fio2) during general anesthesia can reduce lung atelectasis. The objectives are to evaluate the effect of two Fio2 (0.4 and 1) low positive end-expiratory pressure (PEEP) ventilation over perfusion distribution, volume, regional ventilation. These variables were evaluated at PEEP levels unilateral
The aims of this study were to investigate the ability contrast-enhanced dual-energy computed tomography (DECT) for assessing regional perfusion in a model acute lung injury, using dynamic first-pass CT (DynCT) as criterion standard and evaluate if changes caused by prone ventilation are similarly demonstrated DECT DynCT.This was an institutional review board-approved study, compliant with guidelines humane care laboratory animals. A ventilator-induced injury protocol applied 6 landrace...
Abstract Parte superior do formulário Digite um texto ou endereço de site traduza documento. The aim of this study is to evaluate the histological changes in lung parenchyma pigs affected by interstitial disease induced after infusion bone marrow mononuclear cells (BMMCs). Ten female swines were submitted pulmonary fibrosis a single dose intratracheal bleomicine sulfate. Animals arranged into two groups: Group 1: induced‐disease control and 2: cell therapy using BMMCs. Both groups clinically...
The aim of this study was to explore if positive-pressure ventilation delivered by a conventional ICU ventilator at moderately high frequency (HFPPV) allows safe reduction tidal volume (V T) below 6 mL/kg in porcine model severe acute respiratory distress syndrome (ARDS) and lower mean airway pressure than high-frequency oscillatory (HFOV).This is prospective study. In eight pigs (median weight 34 [29,36] kg), ARDS induced pulmonary lavage injurious ventilation. animals were ventilated with...
A apresentação clínica mais freqüente da forma esporádica do carcinoma medular tireóide (CMT) é o bócio uninodular sólido (BUS), esta semelhante aos demais tumores que afetam a glândula. O estabelecimento freqüência de CMT em BUS apresenta implicações importantes não só diagnosticas, como também terapêuticas, visto abordagem cirúrgica diferir outros tireoideanos. Para investigar prevalência BUS, dosamos calcitonina (CT) sérica, marcador bioquímico CMT, por métodos distntos (RIA e IRMA) 60...
Abstract Background Bronchoscopic lung volume reduction (BLVR) with one-way endobronchial valves (EBV) has better outcomes when the target lobe poor collateral ventilation, resulting in complete atelectasis. High-inspired oxygen fraction (F I O 2 ) promotes atelectasis through faster gas absorption after airway occlusion, but its application during BLVR EBV been poorly understood. We aimed to investigate real-time effects of F on regional volumes and ventilation/perfusion by electrical...
To investigate whether performing alveolar recruitment or adding inspiratory pauses could promote physiologic benefits (VT) during moderately-high-frequency positive pressure ventilation (MHFPPV) delivered by a conventional ventilator in porcine model of severe acute respiratory distress syndrome (ARDS).Prospective experimental laboratory study with eight pigs. Induction lung injury sequential pulmonary lavages and injurious was initially performed. Then, animals were ventilated on...