A5068599592- Anesthesia and Sedative Agents
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Barrier Structure and Function Studies
- Airway Management and Intubation Techniques
- Anesthesia and Neurotoxicity Research
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Erythrocyte Function and Pathophysiology
- Retinal Development and Disorders
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Retinal Diseases and Treatments
- Metabolism and Genetic Disorders
- Cell Adhesion Molecules Research
- Connexins and lens biology
- Glaucoma and retinal disorders
- Glycosylation and Glycoproteins Research
- Antibiotics Pharmacokinetics and Efficacy
- Medical History and Innovations
- Blood Coagulation and Thrombosis Mechanisms
- Family and Patient Care in Intensive Care Units
- Hemoglobin structure and function
- Anesthesia and Pain Management
- Healthcare Operations and Scheduling Optimization
Universidad de Santiago de Chile
2024
Louisiana State University Health Sciences Center New Orleans
2021-2024
Louisiana State University
1980-2022
Massachusetts General Hospital
2007-2021
Harvard University
1995-2021
Newton Wellesley Hospital
2020
Pain and Rehabilitation Medicine
2020
Merck & Co., Inc., Rahway, NJ, USA (United States)
2016
Herlev Hospital
2016
University of Copenhagen
2016
Objectives: Among patients with congestive heart failure, B-type natriuretic peptide measurement is useful to estimate filling pressures and prognosticate adverse outcome. However, among critically ill intensive care unit shock, the utility of assess cardiac hemodynamics or prognosis has not been explored. Design: Clinical investigation. Setting: Hospital. Patients: Forty-nine shock indication for pulmonary artery catheterization. Interventions: Analysis was performed on blood obtained at...
Limited data exist regarding ventilation in patients with class III obesity [body mass index (BMI) > 40 kg/m2] and acute respiratory distress syndrome (ARDS). The aim of the present study was to determine whether an individualized titration mechanical according cardiopulmonary physiology reduces mortality ARDS.In this retrospective study, we enrolled adults admitted ICU from 2012 2017 who had ARDS received for 48 h. Enrolled were divided two cohorts: one cohort (2012-2014) ventilator...
A strain of an Enterobacter sp. with reduced susceptibility to imipenem, which produced a plasmid-mediated class carbapenem-hydrolyzing enzyme, KPC-2 beta-lactamase, was isolated from patient sepsis at Boston hospital. This is the first report production plasmid-encoded beta-lactamase by
The fine structural development of rat fetal liver sinusoids from 10 to 22 days gestation was studied. Colloidal carbon (Pelikan ink) injected into 14-22 day fetuses via the umbilical vein assess continuity sinusoidal lining and phagocytic ability developing cells. Endothelial cells, devoid an underlying basal lamina, form bulk vascular at all gestational ages. These cells possess typical intercellular junctions fenestrae with diaphragms before 17 gestation. Transendothelial open...
Abstract Introduction A paucity of literature exists regarding delays in transfer out the intensive care unit. We sought to analyze incidence, causes, and costs delayed from a surgical unit (SICU). Methods An IRB-approved prospective observational study was conducted January 24, 2010, July 31, all 731 patients transferred 20-bed SICU at large tertiary-care academic medical center. Data were collected on who medically ready for floor remained least 1 extra day. Reasons delay examined,...
Abstract Introduction Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is useful in evaluating heart failure, but its role patients with shock the intensive care unit (ICU) not clear. Method Forty-nine consecutive four different ICUs of various types and an indication for pulmonary artery catheter placement were evaluated. Analyses NT-proBNP performed on blood obtained at time results correlated findings. Logistic regression identified independent predictors mortality. Results A wide...
The choriocapillaris is the fenestrated capillary bed in choroid of eye and major blood supply to retinal pigment epithelium (RPE) photoreceptor cells. Bruch's membrane (BM) a multilaminated basement that separates from RPE. In previous study (Pino RM, Essner E; Cell Tissue Res 208:21, 1980) we found choriocapillary endothelium restricted egress ferritin choriocapillaris. present study, hemeproteins were used further establish permeability characteristics this bed. Horseradish peroxidase...
The location and chemical composition of anionic sites in Bruch's membrane (BM) were examined using cationic probe molecules demonstrable electron microscopic preparations tissue digestion with specific degradative enzymes. Ruthenium red native lysozyme revealed densities distributed at regular intervals two major components BM: the basal laminae retinal pigment epithelium (RPE) choriocapillary endothelium (EN). Staining was not observed succinylated (anionic). Colloidal iron also failed to...
Preliminary reports suggest that critically ill patients with coronavirus disease 2019 (COVID-19) infection requiring mechanical ventilation may have markedly increased sedation needs compared ill, mechanically ventilated without COVID-19. We conducted a study to examine sedative use for this patient population within multiple intensive care units (ICUs) of large academic medical center. A retrospective, single-center cohort practices COVID-19 during the first 10 days was in 8 ICUs at...
Hypoxemia of the acute respiratory distress syndrome can be reduced by turning patients prone. Prone positioning (PP) is labor intensive, risks unplanned tracheal extubation, and result in facial tissue injury. We retrospectively examined prolonged, repeated, early versus later PP for 20 with COVID-19 failure. Blood gases ventilator settings were collected before PP, at 1, 7, 12, 24, 32, 39 h after 7 completion PP. Analysis variance was used comparisons baseline values supine positions...
Vascular permeability in the rat retina and choroid was examined by localizing endogenous albumin (radius, 35 A) immunoglobulin G (IgG; radius, 55 immunohistochemistry. Three techniques were used: protein A-horseradish peroxidase, peroxidase-antiperoxidase, avidin-horseradish peroxidase. The peroxidase method yielded least amount of tissue background staining with a high degree reaction product found blood vessels. With this identified retinal capillaries, choriocapillaris, larger choroidal...
Background Comparisons of the intubation conditions with mivacurium and rocuronium from previous reports are confounded by use varied induction regimens. The authors compared mivacurium, rocuronium, a placebo at 90 s their recovery profiles during anesthesia nitrous oxide, oxygen, propofol. Methods After midazolam, fentanyl, propofol in randomized blinded study, 100 patients received one following treatments: 0.25 mg/kg divided doses (0.15 followed 0.1 30 later); 0.45, 0.6, 0.9, or 1.2...
Abstract The choriocapillaris is a fenestrated capillary bed in the eye that restricts egress of exogenous tracer molecules with Einstein‐Stokes radii (ESR) ≥3.2 nm. present study examined permeability its endothelium to endogenous plasma proteins albumin (ESR, 3.5 nm) and IgG 5.5 using ultrastructural immunocytochemistry. Reaction product indicative localization (using Fab‐HRP conjugates) was high lumen. In contrast, neither protein localized extravascularly Bruch's membrane, endothelial...
Kupffer cells are the sinusoidal macrophages of liver. Using ultrastructural phosphatase cytochemical methods, we examined relationship between Golgi apparatus, GERL, and lysosomes in fetal rat livers identified, part, by their ability to phagocytize intravenously injected latex spheres. Thiamine pyrophosphatase (TPPase) activity was localized inner saccules some vesicles region but not GERL. A TPPase-like activity, demonstrable lysosomes, abolished sodium fluoride suppressed alkaline...
These guidelines update the 2002 version of "Clinical Practice Guidelines for Sustained Neuromuscular Blockade in Adult Critically Ill Patient." A task force comprising 17 members Society Critical Care Medicine (SCCM) with particular expertise use neuromuscular blocking agents (NMBAs); a Grading Recommendations Assessment, Development, and Evaluation (GRADE) expert; medical writer met via teleconference three face-to-face meetings communicated e-mail to examine evidence develop these...
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Endogenous peroxidase is the cytochemical marker used to identify Kupffer cells in adult liver. In this study, we show by ultrastructural cytochemistry that of fetal rat liver are endogenous positive. The reaction product localized endoplasmic reticulum including perinuclear cisternae and a few lysosome-like dense bodies. Serial sections Golgi regions suggest GERL not stacks, As liver, endothelial cells. do appear transform from or extravascular developing monocytic present prior bone marrow...
Abstract The bone‐marrow hyphenation of preceeding sinusoids or endothelium in this paper is accordance with the style required by American Journal Anatomy. R.M.P sinusoidal a cellular bar‐rierthat separates developing blood cells extravascular space from peripheral circulation. Mature elements enter circulation via transendothelial migration pores. In present study, monosaccharide constituents on bone marrow were examined using lectin‐affinity cytochemistry. With lectin‐horseradish and...
This study was undertaken to determine the impact of shared decision-making when selecting a sedation option, from no (local anesthetic), minimal (anxiolysis with benzodiazepine) or moderate (benzodiazepine and opiate), for venous access device placement (port-a-cath tunneled catheters) on patient choice, satisfaction recovery time. is an IRB-approved, HIPPA-compliant, retrospective 198 patients (18-85 years old, 60% female) presenting ambulatory vascular interventional radiology department...