A5045589712- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Neonatal Respiratory Health Research
- Mechanical Circulatory Support Devices
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Viral gastroenteritis research and epidemiology
- Family and Patient Care in Intensive Care Units
- Injury Epidemiology and Prevention
- Amoebic Infections and Treatments
- Ultrasound in Clinical Applications
- Mosquito-borne diseases and control
- Abdominal Surgery and Complications
- Clostridium difficile and Clostridium perfringens research
- Thermal Regulation in Medicine
- Head and Neck Surgical Oncology
- Infectious Encephalopathies and Encephalitis
- Hemodynamic Monitoring and Therapy
- Herpesvirus Infections and Treatments
- Electrical and Bioimpedance Tomography
Università Cattolica del Sacro Cuore
2020-2024
Agostino Gemelli University Polyclinic
2021-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2024
University of the Sacred Heart
2021
University of The Sacred Heart
2021
<h3>Importance</h3> High-flow nasal oxygen is recommended as initial treatment for acute hypoxemic respiratory failure and widely applied in patients with COVID-19. <h3>Objective</h3> To assess whether helmet noninvasive ventilation can increase the days free of support COVID-19 compared high-flow alone. <h3>Design, Setting, Participants</h3> Multicenter randomized clinical trial 4 intensive care units (ICUs) Italy between October December 2020, end follow-up February 11, 2021, including 109...
Rationale: The respective effects of positive end-expiratory pressure (PEEP) and support delivered through the helmet interface in patients with hypoxemia need to be better understood. Objectives: To assess (noninvasive ventilation [NIV]) continuous airway (CPAP) compared high-flow nasal oxygen (HFNO) on effort breathe, lung inflation, gas exchange (PaO2/FiO2 ⩽ 200). Methods: Fifteen underwent 1-hour phases (constant FiO2) HFNO (60 L/min), NIV (PEEP = 14 cm H2O, 12 H2O), CPAP H2O) randomized...
<h3>BACKGROUND:</h3> The efficacy of noninvasive oxygenation strategies (NIOS) in treating COVID-19 disease is unknown. We conducted a prospective observational study to assess the rate NIOS failure subjects treated ICU for hypoxemic respiratory due COVID-19. <h3>METHODS:</h3> Patients receiving first-line treatment university hospital were included this study; laboratory data collected upon arrival, and 28-d outcome was recorded. After propensity score matching based on Simplified Acute...
The effects of awake prone position on the breathing pattern hypoxemic patients need to be better understood. We conducted a crossover trial assess physiological in with acute respiratory failure.Fifteen failure and PaO2/FiO2 < 200 mmHg underwent high-flow nasal oxygen for 1 h supine 2 position, followed by final 1-h phase. At end each study phase, following parameters were measured: arterial blood gases, inspiratory effort (ΔPES), transpulmonary driving pressure (ΔPL), rate esophageal...
Positive end-expiratory pressure (PEEP) can potentially modulate inspiratory effort (ΔPes), which is the major determinant of self-inflicted lung injury.
Background Positive end-expiratory pressure (PEEP) benefits in acute respiratory distress syndrome are driven by lung dynamic strain reduction. This depends on the variable extent of alveolar recruitment. The recruitment-to-inflation ratio estimates recruitability across a 10–cm H2O PEEP range through simplified maneuver. Whether is uniform or not this unknown. hypotheses study that represents an accurate estimate PEEP-induced changes strain, but may show nonuniform behavior conventionally...
Personalized positive end-expiratory pressure (PEEP) might foster lung and diaphragm protection in patients with acute respiratory distress syndrome (ARDS) who are undergoing support ventilation (PSV). We aimed to compare the physiologic effects of personalized PEEP set according synchronized electrical impedance tomography (EIT) driving transpulmonary (∆PL) monitoring against a classical lower PEEP/FiO
In non-COVID-19 acute hypoxaemic respiratory failure, the entity of dyspnoea has been associated with severity hypoxaemia, and represents a factor predicting noninvasive ventilation (NIV) need for endotracheal intubation mortality [1]. #COVID19 patients, presence moderate-to-severe is marker disease correlated to clinical outcomes <https://bit.ly/3Bp2G1b> We are grateful all intensive care unit physicians, residents, nurses personnel from participating centres, whose sacrifice, efforts,...
Introduction Remdesivir and Dexamethasone represent the cornerstone of therapy for critically ill patients with acute hypoxemic respiratory failure caused by Coronavirus Disease 2019 (COVID-19). However, clinical efficacy safety concomitant administration (Rem-Dexa) in severe COVID-19 on high flow oxygen (HFOT) or non-invasive ventilation (NIV) remains unknown. Materials methods Prospective cohort study that was performed two medical Intensive Care Units (ICUs) a tertiary university...
Abstract Background Long-term outcomes of patients treated with helmet noninvasive ventilation (NIV) are unknown: safety concerns regarding the risk patient self-inflicted lung injury and delayed intubation exist when NIV is applied in hypoxemic patients. We assessed 6-month outcome who received or high-flow nasal oxygen for COVID-19 respiratory failure. Methods In this prespecified analysis a randomized trial versus (HENIVOT), clinical status, physical performance (6-min-walking-test 30-s...
During laparoscopic surgery, the role of PEEP to improve outcome is controversial. Mechanistically, benefits depend on extent alveolar recruitment, which prevents ventilator-induced lung injury by reducing dynamic strain. The hypotheses this study were that pneumoperitoneum-induced aeration loss and PEEP-induced recruitment are inter-individually variable, recruitment-to-inflation ratio (R/I) can identify patients who benefit from in terms strain reduction. Sequential study. Operating room....