A5031232082- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Meningioma and schwannoma management
- Lung Cancer Diagnosis and Treatment
- Chromatin Remodeling and Cancer
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Tumors and Oncological Cases
- COVID-19 Clinical Research Studies
- Tracheal and airway disorders
- SARS-CoV-2 and COVID-19 Research
- Peptidase Inhibition and Analysis
- Medical Imaging and Pathology Studies
- Myasthenia Gravis and Thymoma
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pituitary Gland Disorders and Treatments
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- IgG4-Related and Inflammatory Diseases
- Genetic factors in colorectal cancer
All India Institute of Medical Sciences
2016-2025
Shree Krishna Hospital
2024
Bhaikaka University
2024
All India Institute of Medical Sciences Bhopal
2020-2021
All India Institute of Medical Sciences Raipur
2020-2021
Massachusetts General Hospital
2019
The University of Texas MD Anderson Cancer Center
2019
Università Cattolica del Sacro Cuore
2019
John Wiley & Sons (United States)
2019
Charles River Laboratories (Netherlands)
2019
Abstract Angiotensin-converting enzyme 2 (ACE2) is a key host protein by which severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enters and multiplies within cells. The level of ACE2 expression in the lung hypothesised to correlate with an increased risk infection complications COrona VIrus Disease 2019 (COVID-19). To test this hypothesis, we compared status immunohistochemistry (IHC) post-mortem samples patients who died COVID-19 obtained from non-COVID-19 for other indications....
A BSTRACT Nocardial infections in neonates are exceptionally rare, posing significant diagnostic challenges due to their atypical presentations and the rarity of such cases. This case report delves into a unique instance nocardial pneumonia neonate, initially misdiagnosed its unconventional clinical presentation absence traditional risk factors for opportunistic infections. The neonate exhibited worsening respiratory distress, misleadingly suggestive more common neonatal conditions or...
<b><i>Introduction:</i></b> Inactivating mutations of the <i>SMARCA4</i> (SWI/SNF-related, matrix-associated, actin-dependent regulator chromatin, subfamily A, member 4) gene and/or loss BRG1 (brahma-related 1) protein defines SMARCA4-deficient thoracic sarcoma (SMARCA4-dTS), an aggressive neoplasm with a usually fatal outcome. Similar mutations/BRG1 is also seen in subset non-small cell lung carcinomas (NSCLCs; SMARCA4-dNSCLCs) that lack alterations...
ABSTRACT To elucidate the molecular mechanisms that manifest lung abnormalities during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, we performed whole-transcriptome sequencing of autopsies from 31 patients with COVID-19 and ten uninfected controls. Using metatranscriptomics, identified existence two distinct signatures lethal COVID-19. The dominant ‘classical’ signature (n=23) showed upregulation unfolded protein response, steroid biosynthesis complement...
Primary skull bone tumors, benign or malignant, are rare, and include a vast repertoire of lesions. These tumors not reported systematically in the literature, with most studies being on individual entities as single case reports.Primary diagnosed over period 12 years were retrieved, histological diagnoses reviewed, clinical parameters noted.We identified 125 primary tumors. The mean age at diagnosis was 32 (range: 2-65 years). Majority patients adults (82.4%); male preponderance noted...
Background NUT carcinoma (NC) is an aggressive neoplasm that often presents with alarge tumor burden and metastases; cytology frequently one of the primary diagnostic modalities. Primary pulmonary NCs are very rare descriptions limited. The current study was performed to analyze cytomorphological features in different samples preparations. Methods A total 15 specimens from 10 patients diagnosed primarily on histology were retrieved reviewed. Results Fifteen samples, including aspirates (5...
Abstract Small cell lung carcinomas (SCLC) are aggressive tumors with high propensity to metastasize. Recent NCCN guidelines have incorporated immunotherapy in extensive stage SCLC. Limited benefit few patients compounded by side effects of unwonted immune-checkpoint-inhibitor (ICPI) usage necessitates identification potential biomarkers predicting response ICPIs. Attempting this, we analysed expression various immunoregulatory molecules tissue biopsies and paired blood samples SCLC...
Abstract Introduction The treatment approach for recently diagnosed advanced non-small cell lung cancer (NSCLC) with EGFR mutations primarily relies on confirming the tissue diagnosis as non-squamous NSCLC. This routine clinical practice of imposes several barriers and delays in turnaround time (TAT) biomarker testing, significantly delaying to treatment. objective this study is investigate ‘plasma first’ detection mutation stage naïve NSCLC patients. Methods We prospectively collected blood...
Ependymomas are relatively rare glial tumours, whose pathogenesis is not well elucidated. They enigmatic tumours that show site-specific differences in their biological behaviour. Recent studies have hypothesized ependymoma cancer stem cells (CSCs) derived from radial glia and express cell markers such as nestin, which associated with a poor prognosis. CSCs reside 'vascular niches', where endothelial molecular signals like vascular growth factor (VEGF) play an important role survival....