A5001675207- Breast Cancer Treatment Studies
- Cancer Immunotherapy and Biomarkers
- Angiogenesis and VEGF in Cancer
- Breast Lesions and Carcinomas
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Lymphatic System and Diseases
- HER2/EGFR in Cancer Research
- Inflammatory Biomarkers in Disease Prognosis
- AI in cancer detection
- Immune cells in cancer
- MRI in cancer diagnosis
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Sarcoma Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Cell Adhesion Molecules Research
- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Maternal and fetal healthcare
- Axon Guidance and Neuronal Signaling
- Medical Imaging Techniques and Applications
- Esophageal Cancer Research and Treatment
AZ Turnhout
2020-2024
KU Leuven
2023-2024
Universitair Ziekenhuis Leuven
2020-2023
Antwerp University Hospital
2005-2022
University of Antwerp
2000-2021
GZA Ziekenhuizen Campus Sint-Augustinus
2008-2020
Iridium Kankernetwerk
2018
Université Paris Cité
2007
Assistance Publique – Hôpitaux de Paris
2007
National Cancer Centre Japan
2007
Abstract The liver is a highly vascularized organ which frequently hosts metastases in patients with colorectal adenocarcinomas. hypothesis of this study that the hypoxic drive angiogenesis might be minimal or absent those growing are capable preserving stromal structure, including numerous sinusoidal blood vessels. Representative paraffin sections from 26 adenocarcinoma were investigated. Three different growth patterns found. In desmoplastic and pushing (42% 46% all metastases,...
Abstract Purpose: Inflammatory breast cancer is a distinct and aggressive form of locally advanced with unique clinical pathological features. Recently, histologic evidence intense angiogenesis was found in inflammatory specimens. The aim this study to confirm the angiogenic phenotype investigate its potential induce lymphangiogenesis. Experimental Design: Real-time quantitative reverse transcriptase-PCR used measure levels mRNA tumor lymphangiogenesis-related factors [vascular endothelial...
Although angiogenesis is a prerequisite for the growth of most human solid tumours, alternative mechanisms vascularisation can be adopted. We have previously described non-angiogenic pattern in liver metastases colorectal adenocarcinomas (CRC) which tumour cells replace hepatocytes at tumour–liver interface, preserving architecture and co-opting sinusoidal blood vessels. The aim this study was to determine whether replacement occurs during metastasis breast (BC) lack an angiogenic switch...
Plasma levels of D-dimer are elevated in cancer patients. Activation the extrinsic coagulation system and fibrinolytic cascade within a tumour is thought to be related with growth, invasion metastasis. We have investigated relationship between these markers fibrin metabolism, standard clinicopathological variables serum angiogenic cytokines three cohorts: group A (n=30) consisted 30 healthy female volunteers, B (n=23) consecutive patients operable breast C (n=84) untreated or progressive...
// François Bertucci 1, 2, 3 , Pascal Finetti 1 Cécile Colpaert 4 Emilie Mamessier Maxime Parizel Luc Dirix 5 Patrice Viens Daniel Birnbaum Steven van Laere Département d'Oncologie Moléculaire, "Equipe Labellisée Ligue Contre le Cancer", Centre de Recherche en Cancérologie Marseille (CRCM), Institut Paoli-Calmettes, INSERM UMR1068, CNRS UMR725, Marseille, France 2 Médicale, CRCM, Faculté Médecine, Aix-Marseille Université, Department of Pathology, GZA Hospitals Sint-Augustinus, Antwerp,...
Abstract Purpose: At the time of diagnosis, metastatic dissemination tumor cells via lymphatic system has occurred in nearly all patients with inflammatory breast cancer (IBC). The objective this study was twofold: (a) to determine which is most suitable marker lymph vessels primary tumors and (b) compare histomorphometric vessel variables IBC non-IBC. Experimental Design: Serial sections 10 IBCs non-IBCs were immunostained for D2-40, LYVE-1, podoplanin, PROX-1. Relative area, perimeters,...
Recently, peritumoural (lympho)vascular invasion, assessed on haematoxylin–eosin (HE)-stained slides, was added to the St Gallen criteria for adjuvant treatment of patients with operable breast cancer (BC). New lymphatic endothelium-specific markers, such as D2-40, make it possible distinguish between blood (BVI) and lymph vessel invasion (LVI). The aim this prospective study quantify compare BVI LVI in a consecutive series BC. Three sections all formalin-fixed paraffin-embedded tissue...
Inflammatory breast cancer (IBC) is a rare and rapidly progressive form of invasive cancer. The aim this study was to explore the clinical evolution, stromal tumour-infiltrating lymphocytes (sTIL) infiltration programmed death-ligand 1 (PD-L1) expression in large IBC cohort. Data were collected prospectively from patients with as part an international collaborative effort since 1996. In total, 143 starting treatment between June 1996 December 2016 included. Clinicopathological variables...
Cadherins are major cell-cell adhesion proteins whose cytoplasmic domains bind to catenin proteins. Strong intercellular depends on linkage of the cadherin/catenin complex actin cytoskeleton via α-catenin. To date, it is not clear how different cell types achieve variable strength clearly needed in a multicellular organism. Here, we report cloning and molecular characterization αT(testis)-catenin, novel human cDNA encoding protein with homology both αE(epithelial)-catenin αN(neural)-catenin....
Cellular neurothekeoma is a recently characterized benign cutaneous neoplasm arising usually on the upper trunk or head and neck of children young adults. Typical histology that lobulated dermal tumor composed spindle epithelioid cells, arranged in fascicles nests, lacking immunore-activity for S-100 protein, but being NK1/C3 positive. We present 10 new cases cellular with atypical histologic features have not been described previously suggested possibility malignancy. The age range affected...
Abstract Purpose: Lymph node (LN) lymphangiogenesis has recently been shown to be important in the premetastatic niche of sentinel LNs. To study its role further metastatic spread human breast cancer, we investigated association angiogenesis and LN metastases with presence nonsentinel cancer patients a positive LN. Experimental Design: Angiogenesis lymphangiogenesis—quantified as endothelial cell proliferation fraction (ECP%) lymphatic ECP (LECP%)—were assessed 65 T1/T2 using CD34/Ki67...
Murine breast cancer models relying on intraductal tumor cell inoculations are attractive because they allow the study of from early ductal carcinoma in situ to metastasis. Using a fully immunocompetent 4T1-based model for triple-negative (TNBC) we aimed investigate immunological responses that guide such progression, focusing prominent role macrophages.Intraductal were performed lactating female mice with luciferase-expressing 4T1 mammary cells either or without additional RAW264.7...