A5018074156- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Lymphoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Lung Cancer Treatments and Mutations
- Psychedelics and Drug Studies
- Advanced MRI Techniques and Applications
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- COVID-19 and healthcare impacts
- Meningioma and schwannoma management
- Head and Neck Cancer Studies
- Histiocytic Disorders and Treatments
- Radiopharmaceutical Chemistry and Applications
- VLSI and Analog Circuit Testing
- Neurofibromatosis and Schwannoma Cases
- Metastasis and carcinoma case studies
- Ultrasound and Hyperthermia Applications
University of Toronto
2015-2025
Sunnybrook Health Science Centre
2020-2025
Health Sciences Centre
2020-2024
McMaster University
2013-2018
Hamilton Health Sciences
2015-2018
St. Joseph’s Healthcare Hamilton
2015-2017
University Health Network
2015
Cancer Care Ontario
2015
Princess Margaret Cancer Centre
2015
Women's College Hospital
2015
MRgFUS is a safe, noninvasive method to deliver spatially targeted monoclonal antibody across the BBB in patients with brain tumors.
The utility of (18)F-FDG PET/CT for response assessment in malignant lung tumors treated with radiofrequency ablation (RFA) and the detection prediction local recurrence was investigated.Between December 17, 2003, April 9, 2008, 68 consecutive patients (mean age, y) 94 pulmonary lesions, including metastases (n = 38) primary cancers 44), underwent RFA. Because inadequate imaging follow-up 12 patients, only 82 lesions were analyzed (CT scans, n 82; 62). median 25 mo (range, 12-66 mo). A...
Background and Objectives: At diagnosis, the initial staging of well-differentiated neuroendocrine tumors (WD NETs) aids in treatment planning. The somatostatin receptor (SSTR)-PET has been recommended for WD NETs although limited data are available on its impact non-gastroeneteropancreatic (GEP) NETs. main purpose this study was to compare stage migration after addition SSTR-PET workup patients at GEP those with non-GEP NETs, potential patient management. Methods: This prospective included...
In patients with squamous cell carcinoma of the anal canal (ACC), disease stage influences treatment plans and determines prognosis. Our purpose was to determine impact PET on initial staging presumed stages II-IV ACC assess association per conventional workup (CW) imaging patient outcomes. Methods: this multicenter registry, CW or equivocal findings for a specific were included. Demographic data according American Joint Committee Cancer (AJCC) version 7 as determined by recorded compared...
Purpose To evaluate the diagnostic accuracy of dynamic‐contrast–enhanced (DCE) MRI in comparison to both 18 F‐FDG‐ and 68 Ga‐DOTATATE‐PET/CT patients with liver metastases neuroendocrine neoplasms (NEN). Materials Methods Thirty‐two hepatic from NEN were examined DCE‐MRI positron emission tomography/computed tomography (PET/CT), using either F‐fluorodeoxyglucose ( F‐FDG) or Ga‐DOTATATE as tracer. was performed at 3 Tesla Gd‐EOB‐DTPA acquiring 48 slices every 2.2 s for 5 min. Three regions...
Purpose To determine the relationship of PET/CT staging to management and outcomes participants with apparent limited-stage (LS) Hodgkin lymphoma (HL) or aggressive non-HL (ANHL) treated curative intent. Materials Methods This prospective multicenter registry included 850 (467 men 383 women; median age, 54.1 years) from nine centers who had LS HL ANHL on basis clinical data CT, equivocal CT for advanced stage, were considered curative-intent first-line therapy. Participants recruited between...
The Ontario PET Registry was established to provide evidence on the clinical impact of 18-FDG-PET/CT (PET) imaging inform Health Insurance Plan funding decisions. melanoma registry assessed use staging by in advanced or high-risk as a useful adjunct and standard radiologic investigation.Between January 2011 July 2013, approximately 319 consecutive patients with potentially resectable localized recurrent disease under consideration for metastasectomy underwent across 9 institutions Ontario....
A growing number of studies have demonstrated the usefulness FDG PET-CT in preoperative assessment soft tissue sarcomas. We report a case patient with known low-grade liposarcoma demonstrating only mild hypermetabolism on study. An incidental osseous lesion was found distal tibia same extremity during initial workup. This tibial significantly more intense study than primary sarcoma. Further investigation showed this to be an unexpected benign fibrous dysplasia. present as example discrepancy...
Purpose The aim of this study was to assess the yield somatostatin receptor PET in patients with clinical, imaging, and/or biochemical suspicion a neuroendocrine tumor (NET). Patients and Methods This analysis includes referred for initial diagnosis an unconfirmed NET, as part prospective, single-arm registry (NCT03873870) assessing utility 68 Ga-DOTATATE PET/CT management NETs. Inclusion criteria cohort consisted elevated biomarkers clinical presentation suspicious negative conventional...
Fibrous dysplasia commonly involves the skull in both its monostotic and polyostotic variants. We present two cases of fibrous involving sphenoid wing, which were strikingly similar their bone scan appearance. Both patients demonstrated intense increased uptake Tc-99m MDP a pattern reminding us "pirate wearing an eyepatch." propose that this characteristic appearance wing be called sign." A review literature revealed several other pathologic conditions have been reported to involve should...
Abstract Background Major depressive disorder (MDD) is a leading cause of disability worldwide across domains health and cognition, affecting overall quality life. Approximately one third individuals with depression do not fully respond to treatments (e.g., conventional antidepressants, psychotherapy) alternative strategies are needed. Recent early phase trials suggest psilocybin may be safe efficacious intervention rapid-acting antidepressant properties. Psilocybin thought exert therapeutic...
<title>Abstract</title> Background The changes in outpatient care delivery during the COVID-19 pandemic represented a natural experiment which allows us to compare outcomes and evaluate impact of physician-patient continuity after different types encounters. Methods Retrospective cohort study using data from 5 linked healthcare databases Alberta capture all encounters (virtual or in-person) for 3.84 million community-dwelling adults between March 1, 2019 February 28, 2023. Results proportion...
To determine if synchronous extrapulmonary malignancies in early stage lung cancer impact survival and cost of care the current era improved therapies diagnostics.Patients with I II were identified from Ontario Cancer Registry prognostic factors obtained provincial health administrative databases. Synchronous defined as those detected within 6 months diagnosis primary. Survival was calculated using Kaplan-Meier method examined based on a 6-month landmark time point. The log-rank test Cox...
Hybrid PET/MRI is a promising tool that can characterize both metabolic and structural information has been used extensively in the context of MI-related heart failure. We propose novel dual-condition protocol be to state cardiac tissue vivo following MI, under different substrate conditions. Our results show significant changes fasting glucose loading conditions, further longitudinal differences remodeling within infarct zone surrounding myocardium. This framework potential testing...
Abstract Background : Major Depressive Disorder (MDD) is a leading cause of disability worldwide across domains health and cognition, affecting overall quality life. Approximately one third individuals with depression do not fully respond to treatments (e.g., conventional antidepressants, psychotherapy) alternative strategies are needed. Recent early phase trials suggest psilocybin may be safe efficacious intervention rapid-acting antidepressant properties. Psilocybin thought exert...