A5023782543- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neuroscience and Neural Engineering
- Pain Management and Treatment
- Treatment of Major Depression
- Electroconvulsive Therapy Studies
- Mental Health Research Topics
- Psychosomatic Disorders and Their Treatments
- Neurotransmitter Receptor Influence on Behavior
- EEG and Brain-Computer Interfaces
- Diet and metabolism studies
- Medical Image Segmentation Techniques
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Brain Tumor Detection and Classification
- Eicosanoids and Hypertension Pharmacology
- Health, Environment, Cognitive Aging
- Psychedelics and Drug Studies
- Traumatic Brain Injury Research
Sunnybrook Health Science Centre
2014-2025
University of Toronto
2016-2025
Health Sciences Centre
2013-2025
Neuromod (Ireland)
2025
Sunnybrook Research Institute
2014-2024
Sunnybrook Hospital
2014-2024
Centre for Addiction and Mental Health
2020-2024
University of British Columbia
2022-2024
University of California, San Diego
2024
Mental Health Research Institute
2020
Ventricular enlargement may be an objective and sensitive measure of neuropathological change associated with mild cognitive impairment (MCI) Alzheimer's disease (AD), suitable to assess progression for multi-centre studies. This study compared (i) ventricular after six months in subjects MCI, AD normal elderly controls (NEC) a study, (ii) volumetric changes between Apolipoprotein E genotypes, (iii) who progressed from MCI AD, (iv) sample sizes studies based on measures enlargement. Three...
Treatment-resistant depression (TRD) is common in older adults. Bilateral repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex for 48 minutes has demonstrated efficacy TRD. Theta burst (TBS), a newer form rTMS, can also be delivered bilaterally using left intermittent TBS and right continuous only 4 minutes.To establish effectiveness tolerability compared with standard rTMS adults TRD.In this randomized noninferiority trial open treatment blinded...
Objective: The study objective was to investigate the predictive value of functional connectivity changes induced by acute repetitive transcranial magnetic stimulation (rTMS) for clinical response in treatment-resistant depression. Methods: Cross-sectional a single concurrent rTMS-fMRI session were assessed 38 outpatients with depression (26 them female; mean age, 41.87 years) who subsequently underwent 4-week course rTMS. rTMS delivered at 1 Hz over right dorsolateral prefrontal cortex....
Abstract Deep brain stimulation has revolutionized the treatment of movement disorders and is gaining momentum in several other neuropsychiatric disorders. In almost all applications this therapy, insertion electrodes into target been shown to induce some degree clinical improvement prior onset. Disregarding phenomenon, commonly referred as ‘insertional effect’, can lead biased results trials, patients receiving sham may still experience symptom amelioration. Similar scenario, an behavioural...
Abstract Hippocampal volumetry is a critical biomarker of aging and dementia, it widely used as predictor cognitive performance; however, automated hippocampal segmentation methods are limited because the algorithms (a) not publicly available, (b) subject to error with significant brain atrophy, cerebrovascular disease lesions, and/or (c) computationally expensive or require parameter tuning. In this study, we trained 3D convolutional neural network using 259 bilateral manually delineated...
To determine if APOE ε4 influences the association between white matter hyperintensities (WMH) and cognitive impairment in Alzheimer disease (AD) dementia with Lewy bodies (DLB).A total of 289 patients (AD = 239; DLB 50) underwent volumetric MRI, neuropsychological testing, genotyping. Total WMH volumes were quantified. Neuropsychological test scores included a confirmatory factor analysis to identify domains encompassing attention/executive functions, learning/memory, language, for each...
Cerebral White Matter Hyperintensities (WMH) are associated with vascular risk factors and age-related cognitive decline. WMH have primarily been global white matter gray (GM) changes less is known about regional effects in GM. The purpose of this study was to test for an association between two GM imaging measures: cerebral blood flow (CBF) voxel-based morphometry (VBM). Twenty-six elderly adults mild severe participated cross-sectional 3 Tesla magnetic resonance (MRI) study. MRI measures...
Background Late-life depression (LLD) is often accompanied by cognitive impairment, which may persist despite antidepressant treatment. Repetitive transcranial magnetic stimulation (rTMS) an efficacious treatment for depression, with potential benefits on functioning. However, research effects inconclusive, relatively sparse in LLD, and predominantly focused group-level changes. This study aimed to explore individual-level changes following rTMS patients LLD. Method Data were analyzed from...
Abstract Background Cognitive dysfunction is a key pathological feature of treatment resistant major depression (TRD) that often overlooked (1). Persistent deficits in cognition are common and serve as mediator psychosocial functional outcomes. Such associated with reduced quality life increased likelihood relapsing (2). Subtle cognitive depressed patients may also evade detection by traditional screening tools. Unfortunately, despite much advancement options, significant proportion who...
To determine the relationship between white matter hyperintensities (WMH) presumed to indicate disease of cerebral small vessels, temporal lobe atrophy, and verbal memory deficits in Alzheimer (AD) other dementias.We recruited groups participants with without AD, including strata extensive WMH minimal WMH, into a cross-sectional proof-of-principle study (n = 118). A consecutive case series from clinic was used as an independent validation sample 702; Sunnybrook Dementia Study; NCT01800214)....
Abstract Introduction Although the apolipoprotein E ε4‐allele ( APOE ‐ε4) is a susceptibility factor for Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), its relationship imaging cognitive measures across AD/DLB spectrum remains unexplored. Methods We studied 298 patients (AD = 250, DLB 48; 38 autopsy‐confirmed; NCT01800214 ) using neuropsychological testing, volumetric magnetic resonance imaging, genotyping to investigate association of ‐ε4 hippocampal volume learning/memory...
Abstract Introduction Cerebral small vessel disease (SVD) is thought to contribute Alzheimer's (AD) through abnormalities in white matter networks. Gray (GM) hub covariance networks share only partial overlap with connectivity, and their relationship SVD has not been examined AD. Methods We developed a multivariate analytical pipeline elucidate the cortical GM thickness systems that covary major network hubs assessed whether neurodegenerative pathologic markers were associated attenuated...
Deep brain stimulation (DBS) has been investigated for neuropsychiatric disorders. In this phase 1 trial, we treated four posttraumatic stress disorder (PTSD) patients with DBS delivered to the subgenual cingulum and uncinate fasciculus. addition validated clinical scales, underwent neuroimaging studies psychophysiological assessments of fear conditioning, extinction, recall. We show that procedure is safe potentially effective (56% reduction in Clinical Administered PTSD Scale scores)....