A5068433570- Inhalation and Respiratory Drug Delivery
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sepsis Diagnosis and Treatment
- Fish Ecology and Management Studies
- Marine and fisheries research
- Estrogen and related hormone effects
- Chronic Lymphocytic Leukemia Research
- Immune Response and Inflammation
- Prostate Cancer Treatment and Research
- Immunodeficiency and Autoimmune Disorders
- Cancer, Lipids, and Metabolism
- Gene expression and cancer classification
- Asthma and respiratory diseases
- Fish Biology and Ecology Studies
- Metabolomics and Mass Spectrometry Studies
- Thermal Regulation in Medicine
- Liver Disease Diagnosis and Treatment
- Advanced Chemical Sensor Technologies
- Hormonal and reproductive studies
- Salivary Gland Disorders and Functions
- Diverse Scientific and Engineering Research
- Facial Rejuvenation and Surgery Techniques
- Child Abuse and Related Trauma
- Cystic Fibrosis Research Advances
- Ophthalmology and Eye Disorders
University of Leicester
2021
Leicester Royal Infirmary
2021
Garvan Institute of Medical Research
2010
Hanson Institute
2010
UNSW Sydney
2010
St Vincent's Clinic
2010
Memorial Sloan Kettering Cancer Center
2010
Monash University
2010
The University of Adelaide
2010
Queensland University of Technology
2010
Background Systemic inflammation is a whole body reaction having an infection-positive (i.e., sepsis) or infection-negative origin. It important to distinguish between these two etiologies early and accurately because this has significant therapeutic implications for critically ill patients. We hypothesized that molecular classifier based on peripheral blood RNAs could be discovered would (1) determine which patients with systemic had sepsis, (2) robust across independent patient cohorts,...
Abstract Introduction Sepsis is a complex immunological response to infection characterized by early hyper-inflammation followed severe and protracted immunosuppression, suggesting that multi-marker approach has the greatest clinical utility for detection, within environment focused on Systemic Inflammatory Response Syndrome (SIRS) differentiation. Pre-clinical research using an equine sepsis model identified panel of gene expression biomarkers define aberrant immune activation. Thus,...
Abstract Background: Epigenetic alterations are common in prostate cancer, yet how these modifications contribute to carcinogenesis is poorly understood. We investigated whether specific histone prognostic for cancer relapse, and the expression of epigenetic genes altered tumorigenesis. Methods: Global levels H3 lysine-18 acetylation (H3K18Ac) lysine-4 dimethylation (H3K4diMe) were assessed immunohistochemically a cohort 279 cases. gene was silico by analysis microarray data from 23 primary...
Quantitative proteomic studies, based on two-dimensional gel electrophoresis, are commonly used to find proteins that differentially expressed between samples or groups of samples. These interest as potential diagnostic prognostic biomarkers, associated with a trait. The complexity data poses many challenges, so while experiments may reveal expressed, these often not significant when subjected rigorous statistical analysis. However, this can be addressed through appropriate experimental...
Purpose To investigate the ability of texture analysis MRI images to stage liver fibrosis. Current noninvasive approaches for detecting fibrosis have limitations and cannot yet routinely replace biopsy diagnosing significant Materials Methods Forty‐nine patients with a range diseases biopsy‐confirmed were enrolled in study. For all scanned T 2 ‐weighted, high‐resolution, spin echo sequence Haralick features applied. The area under receiver operating characteristics curve (AUROC) was used...
A novel antibody microarray has been developed that provides an extensive immunophenotype of leukaemia cells. The assay is a solid phase cell-capture technique in which 82 antigens are studied simultaneously. This paper presents the analysis 733 patients with variety leukaemias and lymphomas from peripheral blood bone marrow. Discriminant Function Analysis expression profiles these 63 normal subjects were clustered showed high levels consistency diagnoses obtained using conventional clinical...
Abstract Mutations in the androgen receptor (AR) have been detected experimental and clinical prostate tumors. Mice with enforced prostate‐specific expression of one such variant, AR‐E231G, invariably develop prostatic intraepithelial neoplasia by 12 weeks metastatic cancer 52 weeks. The aim this study was to identify genes altered prostates AR‐E231G mice at an early stage disease that may act as drivers AR‐mediated tumorigenesis. gene profile tissue from 12‐week‐old compared equivalent...
The Fabens method is commonly used to estimate growth parameters k and l ∞ in the von Bertalanffy model from tag–recapture data. However, of estimation has an inherent bias when individual variable. This paper presents asymptotically unbiassed using a maximum likelihood approach that takes account variability both length age-at-tagging. It assumed each individual's follows curve with its own parameter be constant ensure mean avoid overparameterization. Our also makes more efficient use...
Estimation of von Bertalanffy growth parameters has received considerable attention in fisheries research. Since Sainsbury (1980, Can. J. Fish. Aquat. Sci. 37: 241–247) much this research effort centered on accounting for individual variability the parameters. In paper we demonstrate that, analysis tagging data, Sainsbury's method and its derivatives do not, general, satisfactorily account growth, leading to inconsistent parameter estimates (the bias does not tend zero as sample size...
Various experiments suggest that ovarian follicular recruitment and growth may be increased by testosterone priming. Our aim was to determine the effects of exogenous supplementation in older women on folliculogenesis steroidogenesis. A prospective randomized double-blind placebo-controlled crossover study carried out. Twelve regularly menstruating non-obese aged 38–45 years received a 12-day course transdermal (2.5 mg per patch) or placebo patch, followed 7 days gonadotrophin stimulation....
Medroxyprogesterone acetate (MPA), a component of combined estrogen-progestin therapy (EPT), has been associated with increased breast cancer risk in EPT users. MPA can bind to the androgen receptor (AR), and AR signaling inhibits cell growth tissues. Therefore, aim this study was investigate potential disrupt an ex vivo culture model normal human tissue.Histologically tissues from women undergoing surgical operation were cultured presence or absence native ligand 5α-dihydrotestosterone...
Formoterol fumarate (FF) is a well-established long-acting β2-agonist. This represents the first clinical study of FF in metered-dose inhaler (FF MDI) based on proprietary lipid-based porous-particle engineering technology.In this randomized, double-blind, 5-period, crossover (NCT00880490), subjects received 2.4, 4.8, and 9.6 μg MDI, open-label Foradil(®) Aerolizer(®) (FA) 12 μg, placebo. Spirometry was performed at baseline, 15 30 min, 1, 2, 4, 6, 8, 10, 11.5, h post-dose.Thirty-four were...
IntroductionIn 2002, the Surviving Sepsis Campaign defi ned a strategy that aimed to reduce high mortality due sepsis.One point of this was recommendation recognize sepsis is frequent cause death and economic costs in pediatric intensive care unit.Knowledge disease fi rst step impact it.There are few studies on epidemiology world none Colombia.Hypothesis The epidemiological features Colombian children diff erent from other countries.Methods We constructed website where 14 units across...
Abstract: Circulating low molecular weight (LMW) IgM was demonstrated in five of 38 patients with B cell lymphoproliferative disorders. These all had malignant disease and could be subdivided into two groups. In the first group were three patients, each an associated serum paraprotein; Waldenstrom's macroglobulinemia. one lymphocytic lymphoma. The second did not have paraproteins; lymphoma chronic leukemia. Both these also acquired C1 esterase inhibitor deficiency, a previously recognised...
Background: Most clinical trials of sepsis treatment modalities fail at their primary objective establishing superiority over placebo when added to background standard care.While there is no definitive explanation for the high failure rate, it might be stated that our attempts insert a new therapeutic agent into care encounters severe problems with definition exactly what stage ongoing, and are criteria progression or resolution from time point onwards.Clearly need means defining steps in...
Abstract ‘Factitious illness’ is a recently classified group of diseases characterized by repeated purposeful simulation physical or mental illness in order to obtain medical psychiatric treatment. ‘Münchausen Syndrome’ classical example this group. The case reported 26-year-old Caucasian male who presented with recurrent facial swelling between December 1978 and November 1987. His true condition eluded diagnosis for so long because he repeatedly overt clinical signs which appeared severe...