A5075017370- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Gut microbiota and health
- Immunodeficiency and Autoimmune Disorders
- Clostridium difficile and Clostridium perfringens research
- Autoimmune and Inflammatory Disorders
- Gastrointestinal motility and disorders
- Renal Diseases and Glomerulopathies
- Tuberculosis Research and Epidemiology
- Biosimilars and Bioanalytical Methods
- Colorectal Cancer Screening and Detection
- Escherichia coli research studies
- Vasculitis and related conditions
- Sarcoidosis and Beryllium Toxicity Research
- Blood groups and transfusion
- Peripheral Neuropathies and Disorders
- Whipple's Disease and Interleukins
- Blood transfusion and management
- Gastrointestinal disorders and treatments
- Phytochemistry and biological activities of Ficus species
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Wirral University Teaching Hospital NHS Foundation Trust
2016-2024
University of Liverpool
1983-2022
Arrowe Park Hospital
2019-2022
Aintree University Hospitals NHS Foundation Trust
2021-2022
Aintree University Hospital
2022
Royal Liverpool University Hospital
2010-2012
Royal College of Physicians
2006
Cardiff Royal Infirmary
1997
Wythenshawe Hospital
1996
Walter Reed Army Institute of Research
1964
<h3>Objective</h3> Colonic mucosa-associated <i>Escherichia coli</i> are increased in Crohn9s disease (CD) and colorectal cancer (CRC). They variously haemagglutinate, invade epithelial cell lines, replicate within macrophages, translocate across M (microfold) cells damage DNA<i>.</i> We investigated genes responsible for these effects their co-association colonic mucosal isolates. <h3>Design</h3> A fosmid library yielding 968 clones was prepared <i>E EPI300-T1 using DNA from a...
Abstract Background Intravenous [IV] infliximab is a well-established therapy for inflammatory bowel diseases [IBD] patients. A subcutaneous [SC] formulation of [CT-P13] has recently been shown to be as effective IV after two doses induction in randomised trial, but there are no data support elective switching patients on maintenance therapy. We aimed assess the effectiveness an programme SC CT-P13 treated with infliximab. Methods Patients established infliximab, who switched CT-P13, were...
Summary Background Anti‐tumour necrosis factor (TNF) agents are effective in Crohn's disease but some patients lose response and require alternative biologic therapy. There few data on comparative effectiveness of vedolizumab ustekinumab this setting. Aim To compare the anti‐TNF‐refractory over 12 months. Methods Patients commencing or for with minimum follow‐up months were included. The primary outcome measure was difference steroid‐free remission rates at end induction (2 months) We also...
Twin studies have demonstrated the importance of environmental factors in pathogenesis inflammatory bowel disease, but progress has been relatively slow identifying these, with exception smoking, which is positively associated Crohn's disease and negatively ulcerative colitis. Genetic identified risk alleles are involved host–bacterial interactions mucosal barrier, evidence building for a likely pathogenic role changes gut microbiome, respect to both faecal mucosa-associated microbiota. Some...
Abstract Cystic fibrosis (CF) is caused by mutations in the cystic transmembrane conductance regulator ( CFTR ) gene. Defective leads to accumulation of dehydrated viscous mucus within small intestine, luminal acidification and altered intestinal motility, resulting blockage. These changes promote gut microbial dysbiosis, adversely influencing normal proliferation differentiation epithelial cells. Using Illumina 16S rRNA gene sequencing immunohistochemistry, we assessed mucosa-attached...
Crohn's disease (CD) is associated with defective innate immunity, including impaired neutrophil chemotaxis, and mucosal invasion by bacteria, particularly adherent invasive Escherichia coli that replicate inside macrophage phagolysosomes. We compared CD healthy control (HC) macrophages for their abilities to kill E. generate chemoattractants also assessed the effects of hydroxychloroquine (HCQ) vitamin D on killing phagocytosed coli.Peripheral blood monocyte-derived from HC were bacterial...
Renal Biopsy Observations Following Recovery from Ethylene Glycol Nephrosis Paul Flanagan, Capt., USAF, MC, MC Pathology Service, Walter Reed General Hospital, Washington, D.C. Search for other works by this author on: Oxford Academic Google Scholar John H. Libcke, American Journal of Clinical Pathology, Volume 41, Issue 2, 1 February 1964, Pages 171–175, https://doi.org/10.1093/ajcp/41.2.171 Published: 01 1964 Article history Received: 20 May 1963 Accepted: 03 October
Anti-tumour necrosis factor (TNF) agents are associated with increased infection risk among elderly IBD patients, but little is known about non anti-TNF biologics in this cohort. We examined the safety and effectiveness of ustekinumab Crohn's patients.This retrospective multi-centre cohort study included patients ≥60-years old who commenced ustekinumab. recorded Harvey-Bradshaw index (HBI), concomitant steroid therapy, treatment persistence new infections or malignancies. Primary outcome was...
Clostridium difficile associated diarrhoea has been an increasing problem in the last decade UK and is a cause of significant morbidity. At most severe end spectrum it causes pseudomembranous colitis which mortality rate can be refractory to standard treatments. Here we present three cases proven systemic corticosteroids were used as adjunct treatment, raising possibility new treatment option for this difficult condition.
<h3>Introduction</h3> Mucosal <i>E coli</i>, increased in Crohn9s disease, have an adherent invasive phenotype (AIEC) and replicate within macrophages. AIEC can induce granulomas vitro vivo treatment leads to remission of colitis animal models Crohn9s.<sup>1</sup> Hydroxychloroquine, which alters phagolysosomal pH cellular iron mobilisation, enhances antibiotic efficacy macrophage killing other intra-macrophage organisms (<i>Coxiella, Tropheryma</i>).<sup>2</sup> We postulate...
Necrotizing arteritis with giant cells, involving the aorta, pulmonary and coronary arteries, coronary, splenic, renal arterioles was found at necropsy in a 74-year-old male who had died severe haemolytic anaemia associated cold haemagglutinins. The clinical pathological features of this case are shared by well-recognized forms necrotizing angiitis, particular cell arteritis, but do not conform satisfactorily any these disorders. Cold agglutinin instance suggests possibility an autoimmune aetiology.
Hospital blood banks play a key role in the overall transfusion process and form an important link between Blood Establishment clinical users of products. The implementation quality system will assist ensuring that patients receive safe effective products timely manner. A number technical standards exist which can development appropriate system. Accreditation hospital bank provides external evidence systems are place. Many countries require to be accredited specify need achieved. In other...
Abstract Background Biologic therapies are associated with increased infection risk among elderly patients inflammatory bowel disease (IBD). However, there few data on the safety and effectiveness of ustekinumab compared anti-tumor necrosis factor (anti-TNF) agents in elderly. Methods The study sought to compare anti-TNF Crohn’s (CD) patients. Patients ≥60 years age who commenced or an agent for CD were included this retrospective multicenter cohort. primary outcome was incidence serious...
Abstract A case of chronic facial pain and headache is presented. This was found to be due two pieces windscreen-glass lodged in the superior meatus patient's nose since a road-traffic-accident 14 years earlier. Despite being reported as normal, review previous X-rays her sinuses showed that glass visible. The importance carefully assessing intranasal area on sinus-views illustrated.
<b>Objectives:</b> The study investigated the effectiveness in increasing seat belt use of Ford’s reminder system, a supplementary system that provides intermittent flashing lights and chimes for five minutes if drivers are not belted. <b>Methods:</b> Seat relatively new cars with without was unobtrusively observed as vehicles were brought to dealerships service. <b>Results:</b> Overall rates estimated at 71% 76% reminders (p<0.01). <b>Conclusions:</b> is low United States. present showed...