A5103133115- Inflammatory Bowel Disease
- Acute Lymphoblastic Leukemia research
- Microscopic Colitis
- Pancreatic and Hepatic Oncology Research
- COVID-19 and healthcare impacts
- Helicobacter pylori-related gastroenterology studies
- Diagnosis and treatment of tuberculosis
- Diverticular Disease and Complications
- Pharmaceutical Economics and Policy
- Pediatric Hepatobiliary Diseases and Treatments
- Immunodeficiency and Autoimmune Disorders
- Epigenetics and DNA Methylation
- Galectins and Cancer Biology
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- SARS-CoV-2 and COVID-19 Research
- Mycobacterium research and diagnosis
- Eosinophilic Esophagitis
- Tuberculosis Research and Epidemiology
- Genetic factors in colorectal cancer
- Adolescent and Pediatric Healthcare
- Biliary and Gastrointestinal Fistulas
- Healthcare cost, quality, practices
- Schizophrenia research and treatment
- Viral-associated cancers and disorders
Republic Polytechnic
2023
East Sussex Healthcare NHS Trust
2021
Conquest Hospital
2021
Guy's and St Thomas' NHS Foundation Trust
2014-2019
St Thomas' Hospital
2014-2019
University Gastroenterology
2016
St. Thomas Hospital
2015
Chelsea and Westminster Hospital
2015
Biological Mimetics (United States)
2003
To gain an understanding of the efficacy vedolizumab in a 'real-world' setting.Retrospective cohort study using prospectively maintained clinical records.Two UK tertiary inflammatory bowel disease (IBD) centres.Patients with IBD commenced on at Guy's & St Thomas' and King's College Hospitals during November 2014-November 2015.Vedolizumab, monoclonal antibody to α-4 β-7 integrins that selectively inhibit leucocyte migration into gut.Clinical activity was assessed baseline, weeks 14 30...
Interleukin-19 (IL-19) is a novel cytokine that was initially identified during sequence data base search aimed at finding potential IL-10 homologs. IL-19 shares receptor complex with IL-20, indicating the biological activities of these two cytokines overlap and both may play an important role in regulating development proper functioning skin. We determined crystal structure human recombinant refined it 1.95-Å resolution to <i>R</i>-factor 0.157. Unlike IL-10, which forms intercalated dimer,...
Abstract Non-small cell lung cancer (NSCLC) accounts for about 85% of all cancers and KRAS mutation occurs in 25-30% NSCLC. Therapeutics directly targeting mutant proteins are currently not available. We developed a novel siRNA therapeutic against Glutathione S-Transferase P (GSTP), gene target that is highly expressed NSCLC also involved modulating RAS signaling pathway proteins. GSTP has been known as Phase II detoxification enzyme modulator MAP kinase-related cell-signaling pathways....
Abstract DNA methylation is an important epigenetic modification that widely conserved across animal genomes. It accepted patterns can change in a context-dependent manner, including response to changing environmental parameters. However, this phenomenon has not been analyzed livestock yet, where it holds major potential for biomarker development. Building on the previous identification of population-specific clonal marbled crayfish, we have now generated numerous base-resolution methylomes...
Abstract Dyspepsia is a common symptom and the priority to identify alarm signals that necessitate endoscopy referral. Our Drug review discusses its investigation, management some new drug developments, followed by sources of further information.
Objective: The management of inflammatory bowel disease (IBD) patients on complex medications such as biologic disease-modifying anti-rheumatic drugs (DMARD) requires close supervision. At East Sussex NHS Healthcare Trust (ESHT), the multi-disciplinary team (MDT) already looking after these could benefit from additional knowledge and support a specialist pharmacist (SP). Methods: To assess if MDT an SP, all IBD DMARD adalimumab were identified. patient records screened for demographic data,...
<h3>Introduction</h3> 15% of patients with inflammatory bowel disease (IBD) prescribed azathioprine (AZA)/mercaptopurine (MP) demonstrate a skewed drug metabolism low thioguanine nucleotides (TGN) and unexpectedly high methylmercaptopurine (MeMP) levels. This predicts lack treatment efficacy excess adverse events; however studies on the effect thiopurine hypermethylation (TH) in adult IBD are lacking. Importantly, where identified TH can be circumvented use dose AZA/MP allopurinol. The aim...
<h3>Introduction</h3> There is an unpredictable relationship between thiopurine methyl transferase (TPMT) and hypermethylation. It likely that cytochrome P450 (CYP450) enzymes play a role in the demethylation of methylated mercaptopurine (MMP), altering MMP:Thioguanine nucleotide (TGN) ratio(Table 1). Smoking has been shown to induce CYP450 enzymes. One study on smoking olanzapine demonstrated 6 fold increase activity through smoking.<sup>1</sup> This might suggest could upregulate process,...
<h3>Introduction</h3> Vedolizumab was recently granted NICE approval for moderate-to-severe Crohn’s disease (CD) and ulcerative colitis (UC). Novel pathways agreed by our CCG meant that patients at Guy’s & St. Thomas’ King’s College Hospitals had early access to vedolizumab. <h3>Methods</h3> Records of commencing vedolizumab between Nov 2014–15 were screened. Those completing least 14 weeks treatment included. Clinical activity assessed using Harvey-Bradshaw Index (HBI) or Simple Colitis...
Background: Co-prescription of low dose thiopurine with allopurinol is an increasingly used treatment strategy in IBD for patients who experience adverse effects or have hypermethylation monotherapy. However, there remains debate as to whether monitoring thioguanine nucleotide levels (TGNs) necessary this group patients. Methods: All switched from monotherapy combination therapy were identified pharmacy electronic records. Clinical records these retrospectively reviewed. The first TGN value...
Introduction Current guidelines propose surveillance colonoscopy for patients with long term colonic Crohn’s disease or ulcerative colitis. Guidelines also suggest using chromoendoscopy targeted biopsies of abnormal areas. Previous audits have shown poor adherence to these recommendations. We report the assessment an IBD programme in tertiary centre, having implemented interventions order improve quality service provided. Method To assess efficacy introducing dedicated lists along a change...
<h3>Introduction</h3> Biosimilars of adalimumab are now used throughout the National Health Service (NHS). Patients who switch to biosimilars may develop adverse effects such as cutaneous reactions or disease flares, and sometimes switched back (reverse switching) originator. There is limited information about outcomes these switchbacks, particularly in event flares. At East Sussex NHS Trust (ESHT), clinical regarding switchback patients was collected analysed gain a better understanding...
Cholecystitis is an inflammation of the gallbladder with classic symptoms right upper quadrant abdominal pain and fever. The most common precipitating factor cholelithiasis; however, it sometimes appears in conjunction other hepatobiliary-pancreatic pathology. Management generally done antibiotics supportive care or without cholecystectomy. surgical management practice often limited by surgery time patient suitability considering their likely overall outcome. We have outlined two cases...