A5065968083- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Advanced Radiotherapy Techniques
- Advances in Oncology and Radiotherapy
- Management of metastatic bone disease
- Radiology practices and education
- Innovations in Medical Education
- Prostate Cancer Diagnosis and Treatment
- Ultrasound and Hyperthermia Applications
- Endometrial and Cervical Cancer Treatments
- Radiation Dose and Imaging
- Cardiovascular and Diving-Related Complications
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Advanced X-ray and CT Imaging
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Prostate Cancer Treatment and Research
- Cardiovascular Effects of Exercise
St George's Hospital
2025
East Sussex Healthcare NHS Trust
2025
King's College London
2017-2024
King's College Hospital NHS Foundation Trust
2024
St George’s University Hospitals NHS Foundation Trust
2021-2024
St Thomas' Hospital
2017-2022
Royal Adelaide Hospital
2013-2020
Hypertension Institute
2018
Hartford Financial Services (United States)
2018
Royal Darwin Hospital
2013
Background: The Lesion Index (LSI) is a proprietary algorithm from Abbott Medical combining contact force, radiofrequency application duration, and current. It can be displayed during ablation with the TactiCath force catheter. LSI was designed to provide real-time lesion formation feedback hypothesized estimate diameter. Methods Results: Before ablation, animals underwent cardiac computed tomography assess atrial tissue thickness. Ablation lines (n=2–3 per animal) were created in right...
Cardiac conduction properties exhibit large variability, and affect patient-specific arrhythmia mechanisms. However, it is challenging to clinically measure velocity (CV), anisotropy fibre direction. Our aim develop a technique estimate direction from available electrical recordings.We developed validated automated algorithms for estimating cardiac CV anisotropy, any distribution of recording locations on the atrial surface. The first algorithm elliptical wavefront fitting single activation...
Pulsed-field ablation (PFA) is a novel, non-thermal technique for atrial fibrillation (AF) ablation, known its tissue specificity and reduced risk of collateral damage. However, impact on cardiac conduction pathways in patients with pre-existing abnormalities not well understood. We present the first documented case transient block observed during PFA AF. A late 60s male paroxysmal AF dual chamber pacemaker sinus node disease underwent successful using 31 mm pentaspline FARAPULSE catheter....
Treatments for persistent atrial fibrillation (AF) offer limited efficacy. One potential strategy aims to return the right atrium (RA) sinus rhythm (SR) by ablating interatrial connections (IAC) isolate atria, but there is clinical data evaluate this ablation approach. We aimed use simulation and predict patient-specific suitability of IAC treat AF.Persistent AF was simulated in 12 geometries, incorporating electrophysiological heterogeneity fibres, with at Bachmann's bundle, coronary sinus,...
Purpose: The radiotherapeutic management of painful bone metastases is controversial, with several institutional and national guidelines advocating use single-fraction radiotherapy. We aimed to determine patient choice fractionation schedule after involvement in the decision-making process by a decision board. Patients Methods: Advantages disadvantages two schedules (24 Gy six fractions v 8 one fraction) used randomized Dutch Bone Metastasis Study were discussed patients using asked choose...
Abstract Introduction Bipolar voltage is used during electroanatomic mapping to define abnormal myocardium, but the effect of activation rate on bipolar not known. We hypothesized that may change in response rate. By examining corresponding unipolar signals we sought determine mechanisms such changes. Methods and results LA extrastimulus was performed CS pacing 10 patients undergoing first time paroxysmal atrial fibrillation ablation. electrograms were recorded using a PentaRay catheter...
Theoretical benefits of real-time MRI guidance over conventional electrophysiology include contemporaneous 3D substrate assessment and accurate intra-procedural evaluation ablation lesions. We review the unique challenges inherent to MRI-guided how translate potential in treatment cardiac arrhythmias. Over last 5 years, there has been substantial progress, initially animal models more recently clinical studies, establish methods develop workflows within MR environment that resemble those...
Abstract Aims Existing strategies that identify post-infarct ventricular tachycardia (VT) ablation target either employ invasive electrophysiological (EP) mapping or non-invasive modalities utilizing the electrocardiogram (ECG). Their success relies on localizing sites critical to maintenance of clinical arrhythmia, not always recorded 12-lead ECG. Targeting VT by electrograms (EGM) recordings stored in implanted devices may aid planning, enhancing safety and speed potentially reducing need...
Magnetic resonance imaging (MRI) is the gold standard for defining myocardial substrate in 3D and can be used to guide ventricular tachycardia ablation. We describe feasibility of using a prototype magnetic resonance-guided electrophysiology (MR-EP) system pre-clinical model perform real-time MRI-guided epicardial mapping, ablation, lesion with active catheter tracking.Experiments were performed vivo pigs (n = 6) an MR-EP guidance research (Siemens Healthcare) irrigated ablation (Vision-MR,...
The multiple wavelets and functional re-entry hypotheses are mechanistic theories to explain atrial fibrillation (AF). If valid, a chamber's ability support AF should depend upon the left size, conduction velocity (CV), refractoriness. Measurement of these parameters could provide new therapeutic target for AF. We investigated relationship between effective conducting size (LAECS ), function area, CV refractoriness, vulnerability in patients undergoing ablation.Activation mapping was...
Purpose Pre‐interventional assessment of atrial wall thickness (AWT) and subject‐specific variations in the anatomy pulmonary veins may affect success rate RF ablation procedures for treatment fibrillation (AF). This study introduces a novel non‐contrast enhanced 3D whole‐heart sequence providing simultaneous information on cardiac anatomy—including both arterial venous system—(bright‐blood volume) AWT (black‐blood volume). Methods The proposed MT‐prepared bright‐blood black‐blood phase...
Abstract Aims A point-by-point workflow for pulmonary vein isolation (PVI) targeting pre-defined Ablation Index values (a composite of contact force, time, and power) minimizing interlesion distance may optimize the creation contiguous ablation lesions whilst scar formation. We aimed to compare formation in patients undergoing PVI using this a continuous catheter drag workflow. Methods results Post-ablation cardiovascular magnetic resonance imaging was performed 1st-time parameter-guided (n...
Abstract Introduction Multiple cardiac magnetic resonance (CMR)‐derived indices of atrial fibrillation (AF) substrate have been shown in isolation to predict long‐term outcome following catheter ablation. Left (LA) fibrosis, LA volume, ejection fraction (EF), left ventricular (LVEF), shape (sphericity) and pulmonary vein anatomy all correlate with late AF recurrence. This study aimed validate assess the relative contribution multiple a single‐center study. Methods Results Eighty‐nine...
Background: Pathological atrial fibrosis is a major contributor to sustained fibrillation. Currently, late gadolinium enhancement (LGE) scans provide the only noninvasive estimate of fibrosis. However, widespread adoption LGE has been hindered partly by nonstandardized image processing techniques, which can be operator and algorithm dependent. Minimal validation limited access transparent software platforms have also exacerbated problem. This study aims from cardiac magnetic resonance using...
The purpose of this report is to review the complications related different methods anesthesia for high-dose-rate (HDR) brachytherapy cervical carcinoma. All patients diagnosed with cancer between 1999 and 2002 treated 3-channel HDR were entered. Complications due each fraction graded using Common Toxicity Criteria. Eighty-four fractions delivered 18 patients: 19 under general (GA), 41 topical sedation, 5 paracervical nerve block, conscious sedation. Thirteen reported: 12 GA 1 block. Of GA,...
Intergroup 0116 (INT-0116) established adjuvant chemoradiation as the standard of care for resected high-risk adenocarcinoma stomach in United States. However, remains controversial many parts Asia and Europe, where patients tend to undergo a more thorough D2 dissection. In INT-0116, 90% had limited or inadequate node dissection (D0 D1). Also, 17% arm discontinue treatment because toxicities. The objectives this retrospective study are report clinical outcomes cohort who were mostly treated...
The ability to determine the severity of renal fibrosis, which is involved in most chronic kidney diseases, may be beneficial for monitoring disease progression and management. aim this study was assess a new method involving gold nanoparticles conjugated an anti-collagen-I antibody (Co-I-AuNPs) as computed tomography (CT) imaging contrast evaluation fibrosis situ.Gold were prepared using chloride reduction with sodium citrate coated polyethylene glycol (PEG), their size determined by...