A5101691845- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Head and Neck Cancer Studies
- Metastasis and carcinoma case studies
- Advanced Radiotherapy Techniques
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Advances in Oncology and Radiotherapy
- Esophageal and GI Pathology
- Oral health in cancer treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Occupational and environmental lung diseases
- Management of metastatic bone disease
- Esophageal Cancer Research and Treatment
- Pleural and Pulmonary Diseases
- Renal cell carcinoma treatment
- Colorectal Cancer Surgical Treatments
National University Cancer Institute, Singapore
2015-2024
National University Health System
2010-2024
National University Hospital
2012-2023
National University of Singapore
2010-2021
The University of Melbourne
2019
Tan Tock Seng Hospital
2006-2016
The purpose of this study was to report the outcomes patients with symptomatic locally advanced/recurrent gastric cancer treated radiotherapy (RT) using modern 3-dimensional conformal techniques. We retrospectively reviewed who had palliative RT for index symptoms bleeding, pain, and obstruction. Study endpoints included symptom response, median survival, treatment toxicity. Of 115 age 77 years, 78 (67.8%) metastatic disease at time treatment. Index were obstruction in 89.6%, 9.2%, 14.3%...
In December 2019, pneumonia of unknown cause was reported by China to WHO. The outbreak found be caused a coronavirus which officially named "severe acute respiratory syndrome 2" (SARS-CoV-2), and the disease it 'COVID-19'. first case in Singapore confirmed on 23rd January 2020. With lessons learnt from SARS epidemic 2003 H1N1 flu pandemic 2009, much better prepared deal with virus outbreak. government has taken swift measures contain break chain transmission. Healthcare workers face...
Abstract To evaluate the response and quality of life palliative gastric radiotherapy in patients with symptomatic locally advanced cancer. Patients bleeding, pain or obstruction were treated to a dose 36 Gy 12 daily fractions. The primary outcomes symptom rates. Secondary included overall survival, adverse events proportion ≥10‐point absolute improvement fatigue, nausea/vomiting subscales EORTC Qualify Life Questionnaire C30 ( QLQ ‐C30) dysphagia/pain specific module STO 22) at end RT 1...
Abstract Background Radiation therapy is an important cancer treatment modality in both adjuvant and definitive setting, however, the use of radiation for elective regional lymph nodes controversial pancreatic cancer. No consensus on proper selection delineation subclinical nodal areas or has been suggested either conclusively proposed further investigation. This analysis aims to study pattern node metastasis through a pooled published results after radical tumor resection with histological...
Objectives: To determine the pathological response rates and toxicity in patients with locally advanced rectal cancer treated concurrent capecitabine dose escalated intensity modulated radiotherapy (IMRT) Methods: Patients stage II or III adenocarcinoma of rectum were preoperative IMRT. Dose was 825mg/m2, 5 days a week for weeks. IMRT used to deliver 45Gy 25 fractions (1.8Gy per fraction daily, over weeks) regional lymphatics areas at risk harbouring microscopic disease. A concomitant...
Intergroup 0116 (INT-0116) established adjuvant chemoradiation as the standard of care for resected high-risk adenocarcinoma stomach in United States. However, remains controversial many parts Asia and Europe, where patients tend to undergo a more thorough D2 dissection. In INT-0116, 90% had limited or inadequate node dissection (D0 D1). Also, 17% arm discontinue treatment because toxicities. The objectives this retrospective study are report clinical outcomes cohort who were mostly treated...
The advent of immune checkpoint targeted immunotherapy has seen a spectrum immune-related phenomena in both tumor responses and toxicities. We describe case pseudoprogression that pushes the limits response criteria challenges boundaries definitions set by trial protocols. A middle-aged man with conventional clear cell renal carcinoma (RCC) had received multiple prior systemic treatments including vascular endothelial growth factor receptor tyrosine kinase inhibitors, as well surgeries...
▪ Objective: To evaluate the effectiveness of practice guidelines for return to work after acute myocardial infarction when disseminated from a university-based setting practice-based setting. Design: Randomized clinical trial. Patients: A total 187 patients with uncomplicated infarction. Intervention: Patients were randomly assigned intervention (n = 95) or usual care 92). The consisted treadmill test, counseling session based on test results, and consultation letter cardiologist primary...
Background: Atypical response patterns have been a topic of increasing relevance since the advent immune checkpoint inhibitors (ICIs), challenging traditional RECIST (Response Evaluation Criteria in Solid Tumors) method tumor assessment. Newer immune-related criteria can allow for evolution radiologic pseudoprogression, but still fail to capture full range atypical encountered clinical reporting. Methods: We did detailed lesion-by-lesion analysis serial imaging 46 renal cell carcinoma (RCC)...
Spontaneous regression of non-small cell lung cancer is exceptionally rare.Treatment-related toxicity.We report a case patient diagnosed with locally advanced cancer.The declined potentially curative treatment, and did not receive any anti-cancer treatment.He has survived more than two years since his initial diagnosis, maintaining good performance status. Serial imaging computed tomography scans showed tumour near-complete resolution disease.Spontaneous cancer, by virtue its scarcity, been...
Abstract The aim of this retrospective national cohort study is to assess the association between various radiation heart dosimetric parameters (RHDPs), acute myocardial infarct (AMI) and overall survival (OS) outcomes in non-small cell lung cancer (NSCLC) patients treated with post-operative thoracic radiotherapy (PORT) using contemporary techniques. We identified stage I III NSCLC PORT at 2 institutions from 2007 2014. linked their electronic medical records AMI death registries....