A5003963269- Functional Brain Connectivity Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Craniofacial Disorders and Treatments
- Glioma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Neonatal and fetal brain pathology
- Brain Metastases and Treatment
- Neural dynamics and brain function
- Child and Adolescent Psychosocial and Emotional Development
- Advanced Neuroimaging Techniques and Applications
- Metabolism and Genetic Disorders
- Cleft Lip and Palate Research
- Birth, Development, and Health
- Lung Cancer Treatments and Mutations
- Advanced MRI Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Vascular Malformations Diagnosis and Treatment
- Tumors and Oncological Cases
- Cerebrospinal fluid and hydrocephalus
- Mitochondrial Function and Pathology
- Cerebral Venous Sinus Thrombosis
- Meningioma and schwannoma management
- RNA modifications and cancer
- Neural and Behavioral Psychology Studies
- Intracerebral and Subarachnoid Hemorrhage Research
Singapore Institute for Clinical Sciences
2021-2025
National University Hospital
2015-2025
Agency for Science, Technology and Research
2021-2025
National University Health System
2017-2025
University Health System
2024-2025
National University of Singapore
1995-2025
SingHealth Polyclinics
2021
Great Ormond Street Hospital for Children NHS Foundation Trust
2018-2019
National Neuroscience Institute
2013
Resting-state fMRI is commonly used to derive brain parcellations, which are widely for dimensionality reduction and interpreting human neuroscience studies. We previously developed a model that integrates local global approaches estimating areal-level cortical parcellations. The resulting local-global parcellations often referred as the Schaefer However, lack of homotopic correspondence between left right parcels has limited their use lateralization Here, we extend our previous Using...
A balanced excitation-inhibition ratio (E/I ratio) is critical for healthy brain function. Normative development of cortex-wide E/I remains unknown. Here, we noninvasively estimate a putative marker whole-cortex by fitting large-scale biophysically plausible circuit model to resting-state functional MRI (fMRI) data. We first confirm that our generates realistic dynamics in the Human Connectome Project. Next, show estimated sensitive gamma-aminobutyric acid (GABA) agonist benzodiazepine...
Abstract Early-life adversity (ELA) exposure is suggested to accelerate development. However, the influence of ELA on neurodevelopmental trajectories has not been assessed directly but largely inferred from retrospective reporting in adult cohorts. Using multimodal neuroimaging data a pediatric cohort study ( N = 549), we modeled over childhood with structure–function coupling (SC–FC), correlation between structural and functional connectivity. A linear decrease SC–FC was observed age 4.5...
Abstract Background Screen time in infancy is linked to changes social-emotional development but the pathway underlying this association remains unknown. We aim provide mechanistic insights into using brain network topology and examine potential role of parent–child reading mitigating effects screen time. Methods examined on linear regression analysis tested if mediated between later socio-emotional competence. Lastly, we was a moderator link topology. Results Infant significantly associated...
Brain age has emerged as a powerful tool to understand neuroanatomical aging and its link health outcomes like cognition. However, there remains lack of studies investigating the rate brain relationship Furthermore, most models are trained tested on cross-sectional data from primarily Caucasian, adult participants. It is thus unclear how well these generalize non-Caucasian participants, especially children. Here, we previously published deep learning model Singaporean elderly participants...
Biophysical modeling provides mechanistic insights into brain function, from single-neuron dynamics to large-scale circuit models bridging macro-scale activity with microscale measurements. are governed by biologically meaningful parameters, many of which can be experimentally measured. Some parameters unknown, and optimizing their values dramatically improve adherence experimental data, significantly enhancing biological plausibility. Previous optimization methods — such as exhaustive...
Early differences in reward behavior have been linked to executive functioning development. The nucleus accumbens (NAc) and orbitofrontal cortex (OFC) are activated by reward-related tasks identified as key nodes of the brain circuit that underlie processing. We aimed investigate relation between NAc-OFC structural functional connectivity preschool children, well associations with future sensitivity function. showed were not significantly associated but both independently predicted males a...
Early life adversity has been posited to influence the pace of structural neurodevelopment. Most research, however, relied on cross-sectional data, which do not reveal whether neurodevelopmental change is accelerated or slowed following early exposures. In a birth cohort study that included neuroimaging data obtained at 4.5, 6, and 7.5 years age (N=784), we examined associations among cumulative measure perinatal relative resources, nonlinear trajectories hippocampal amygdala volume,...
Erdheim-Chester disease involving breast and muscle: imaging findings.A P Tan, L K Tan I H ChooAudio Available | Share
Background Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these can be transmitted across generations; however, the mechanisms underlying intergenerational impacts maternal early‐life trauma on child remain unknown. Methods The current study used a prospective longitudinal design determine unique joint contributions childhood (neglect abuse) prenatal postnatal mental (anxiety depressive...
OBJECTIVE. The purpose of this article is to describe my institution's experience using a black bone sequence (a 3D low flip angle gradient-echo MRI sequence) in children with craniosynostosis and present our brain protocol for the imaging craniosynostosis. CONCLUSION. proposed has potential replace CT diagnosis surveillance excellent soft-tissue resolution hence superior detection associated intracranial anomalies complications.
Brain age has emerged as a powerful tool to understand neuroanatomical aging and its link health outcomes like cognition. However, there remains lack of studies investigating the rate brain relationship Furthermore, most models are trained tested on cross-sectional data from primarily Caucasian, adult participants. It is thus unclear how well these generalize non-Caucasian participants, especially children. Here, we previously published deep learning model Singaporean elderly participants...